Search Results - "Henriques, Catarina M"

Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease by Henriques, Catarina M, Ferreira, Miguel Godinho

“…Telomere length, unlike most genetic traits, is epigenetic, in the sense that it is not fully coded by the genome. Telomeres vary in length and randomly assort…”
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Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish by Carneiro, Madalena C, Henriques, Catarina M, Nabais, Joana, Ferreira, Tânia, Carvalho, Tânia, Ferreira, Miguel Godinho

“…Telomeres shorten with each cell division and telomere dysfunction is a recognized hallmark of aging. Tissue proliferation is expected to dictate the rate at…”
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Telomerase is required for zebrafish lifespan by Henriques, Catarina M, Carneiro, Madalena C, Tenente, Inês M, Jacinto, António, Ferreira, Miguel Godinho

“…Telomerase activity is restricted in humans. Consequentially, telomeres shorten in most cells throughout our lives. Telomere dysfunction in vertebrates has…”
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A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish by Ellis, Pam S, Martins, Raquel R, Thompson, Emily J, Farhat, Asma, Renshaw, Stephen A, Henriques, Catarina M

“…Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with…”
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Correction: Telomerase Is Required for Zebrafish Lifespan by Henriques, Catarina M, Carneiro, Madalena C, Tenente, Inês M, Jacinto, António, Ferreira, Miguel Godinho

“…[This corrects the article DOI: 10.1371/journal.pgen.1003214.]…”
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Consequences of telomere shortening during lifespan by Henriques, Catarina M, Ferreira, Miguel Godinho

“…Highlights ► Telomeres shorten with age in humans. ► Whether the consequences of telomere dysfunction in naturally ageing individuals is the limiting factor in…”
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Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina by Martins, Raquel R., Zamzam, Mazen, Tracey‐White, Dhani, Moosajee, Mariya, Thummel, Ryan, Henriques, Catarina M., MacDonald, Ryan B.

“…Ageing is a significant risk factor for degeneration of the retina. Müller glia cells (MG) are key for neuronal regeneration, so harnessing the regenerative…”
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A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo by Morsli, Samir, Henriques, Catarina M., Ellis, Pamela S., Mortiboys, Heather, Baxendale, Sarah, Loynes, Catherine A., Renshaw, Stephen A., Bellantuono, Ilaria

“…Senescence drives the onset and severity of multiple ageing‐associated diseases and frailty. As a result, there has been an increased interest in mechanistic…”
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Interventions for age-related diseases: Shifting the paradigm by Figueira, Inês, Fernandes, Adelaide, Mladenovic Djordjevic, Aleksandra, Lopez-Contreras, Andres, Henriques, Catarina M., Selman, Colin, Ferreiro, Elisabete, Gonos, Efstathios S., Trejo, José Luis, Misra, Juhi, Rasmussen, Lene Juel, Xapelli, Sara, Ellam, Timothy, Bellantuono, Ilaria

“…•Age is the most important risk factor for age-related diseases.•Age-related multimorbidity impacts on healthcare costs and quality of life.•Common mechanisms…”
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IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells by Henriques, Catarina M., Rino, José, Nibbs, Robert J., Graham, Gerry J., Barata, João T.

“…Interleukin-7 (IL-7) is an essential cytokine for T-cell development and homeostasis. It is well established that IL-7 promotes the transcriptional…”
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How to Catch a Smurf? - Ageing and Beyond… In vivo Assessment of Intestinal Permeability in Multiple Model Organisms by Martins, Raquel R, McCracken, Andrew W, Simons, Mirre J P, Henriques, Catarina M, Rera, Michael

“…The Smurf Assay (SA) was initially developed in the model organism where a dramatic increase of intestinal permeability has been shown to occur during aging…”
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Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish: e1005798 by Carneiro, Madalena C, Henriques, Catarina M, Nabais, Joana, Ferreira, Tânia, Carvalho, Tânia, Ferreira, Miguel Godinho

“…Telomeres shorten with each cell division and telomere dysfunction is a recognized hallmark of aging. Tissue proliferation is expected to dictate the rate at…”
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Telomerase Is Required for Zebrafish Lifespan. e1003214 by Henriques, Catarina M, Carneiro, Madalena C, Tenente, Ines M, Jacinto, Antonio, Ferreira, Miguel Godinho

“…Telomerase activity is restricted in humans. Consequentially, telomeres shorten in most cells throughout our lives. Telomere dysfunction in vertebrates has…”
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IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells by Henriques, Catarina M, Rino, José, Nibbs, Robert J, Graham, Gerry J, Barata, João T

“…Interleukin-7 (IL-7) is an essential cytokine for T-cell development and homeostasis. It is well established that IL-7 promotes the transcriptional…”
Get full text