Search Results - "Henras, Anthony K."
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The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis
Published in Nucleic acids research (28-02-2024)“…Abstract During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the unidirectional maturation of nascent pre-ribosomal subunits…”
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An overview of pre-ribosomal RNA processing in eukaryotes
Published in Wiley interdisciplinary reviews. RNA (01-03-2015)“…Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms. In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S…”
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A ribosome assembly stress response regulates transcription to maintain proteome homeostasis
Published in eLife (24-05-2019)“…Ribosome biogenesis is a complex and energy-demanding process requiring tight coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given…”
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The DEAD-box protein Dbp6 is an ATPase and RNA annealase interacting with the peptidyl transferase center (PTC) of the ribosome
Published in Nucleic acids research (25-01-2023)“…Ribosomes are ribozymes, hence correct folding of the rRNAs during ribosome biogenesis is crucial to ensure catalytic activity. RNA helicases, which can…”
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The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly
Published in Nature communications (22-10-2021)“…Early pre-60S ribosomal particles are poorly characterized, highly dynamic complexes that undergo extensive rRNA folding and compaction concomitant with…”
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The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction
Published in Nature communications (31-10-2024)“…Intrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly…”
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Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation
Published in Nucleic acids research (20-06-2017)“…The poly-A specific ribonuclease (PARN), initially characterized for its role in mRNA catabolism, supports the processing of different types of non-coding RNAs…”
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Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation
Published in Nucleic acids research (23-09-2022)“…Eukaryotic ribosome synthesis involves more than 200 assembly factors, which promote ribosomal RNA (rRNA) processing, modification and folding, and assembly of…”
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Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast
Published in Nature communications (22-10-2021)“…Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) containing ribosomal RNA (rRNA)…”
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The Npa1p complex chaperones the assembly of the earliest eukaryotic large ribosomal subunit precursor
Published in PLoS genetics (31-08-2018)“…The early steps of the production of the large ribosomal subunit are probably the least understood stages of eukaryotic ribosome biogenesis. The first specific…”
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The Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae
Published in International journal of molecular sciences (09-02-2023)“…Ribosome synthesis is a complex process that involves a large set of protein -acting factors, among them DEx(D/H)-box helicases. These are enzymes that carry…”
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RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit
Published in PLoS genetics (14-06-2021)“…Ribosome biogenesis lies at the nexus of various signaling pathways coordinating protein synthesis with cell growth and proliferation. This process is…”
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Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I
Published in PLoS genetics (28-05-2019)“…Most transcriptional activity of exponentially growing cells is carried out by the RNA Polymerase I (Pol I), which produces a ribosomal RNA (rRNA) precursor…”
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Mitochondrial Ribosomal Protein MRPS15 Is a Component of Cytosolic Ribosomes and Regulates Translation in Stressed Cardiomyocytes
Published in International journal of molecular sciences (13-03-2024)“…Regulation of mRNA translation is a crucial step in controlling gene expression in stressed cells, impacting many pathologies, including heart ischemia. In…”
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Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia
Published in eLife (22-12-2022)“…Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to hypoxia, (lymph)angiogenic factors responsible for tissue…”
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Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia
Published in eLife (09-12-2019)“…Hypoxia, a major inducer of angiogenesis, triggers major changes in gene expression at the transcriptional level. Furthermore, under hypoxia, global protein…”
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Coupling Between Production of Ribosomal RNA and Maturation: Just at the Beginning
Published in Frontiers in molecular biosciences (26-10-2021)“…Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35S/47S in yeast/human) is…”
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Contributions of Trf4p- and Trf5p-dependent polyadenylation to the processing and degradative functions of the yeast nuclear exosome
Published in RNA (Cambridge) (01-01-2006)“…The nuclear exosome is involved in a large number of RNA processing and surveillance pathways. RNase III cleavage intermediates destined to be 3'-processed or…”
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Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles
Published in Nucleic acids research (01-04-2012)“…Yeast snR30 is an essential box H/ACA small nucleolar RNA (snoRNA) that promotes 18S rRNA processing through forming transient base-pairing interactions with…”
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Evolutionarily Conserved Function of RRP36 in Early Cleavages of the Pre-rRNA and Production of the 40S Ribosomal Subunit
Published in Molecular and Cellular Biology (01-03-2010)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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