Search Results - "Henrar, R.E.C."

In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS by Nuijen, B., Bouma, M., Henrar, R.E.C., Brauns, U., Bette, P., Bult, A., Beijnen, J.H.

“…The novel anticancer agent BIBX1382BS is a representative of the human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. BIBX1382BS, for…”
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EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models by Hendriks, H R, Pizao, P E, Berger, D P, Kooistra, K L, Bibby, M C, Boven, E, Dreef-van der Meulen, H C, Henrar, R E, Fiebig, H H, Double, J A

“…EO9 is a novel and fully synthetic bioreductive alkylating indoloquinone. Although structurally-related to mitomycin C, EO9 exhibits a distinct preclinical…”
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Revisions of general guidelines for the preclinical toxicology of new cytotoxic anticancer agents in Europe by Buttles, S.S., Newell, D.R., Henrar, R.E.C., Connors, T.A.

“…In 1980, the Cancer Research Campaign (CRC) defined minimal toxicology requirements for the testing of novel anticancer drugs prior to Phase I clinical trials…”
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Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244) by Vries, J D, Doppenberg, W G, Henrar, R E, Bult, A, Beijnen, J H

“…The chemical stability of the novel anticancer agent carzelesin in aqueous buffer/acetonitrile (1:1, v/v) mixtures has been investigated utilizing a…”
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Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-substance P {6-11} by JONKMAN-DE VRIES, J. D, ROSING, H, TALSMA, H, HENRAR, R. E. C, KETTENES-VAN DEN BOSCH, J. J, BULT, A, BEIJNEN, J. H

“…The aim of this study was to develop a stable parenteral dosage form for the investigational cytotoxic drug [Arg6, D-Trp79,MePhe8]-Substance P [6-11]…”
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Preclinical antitumour activity and animal toxicology studies of rhizoxin, a novel tubulin-interacting agent by Hendriks, H R, Plowman, J, Berger, D P, Paull, K D, Fiebig, H H, Fodstad, O, Dreef-van der Meulen, H C, Henrar, R E, Pinedo, H M, Schwartsmann, G

“…Rhizoxin is a 16-membered antifungal macrocyclic lactone isolated from the plant pathogenic fungus Rhizopus chinensis. The compound binds to tubulin,…”
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Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction by Rosing, H, Hillebrand, M.J.X, Jimeno, J.M, Gómez, A, Floriano, P, Faircloth, G, Cameron, L, Henrar, R.E.C, Vermorken, J.B, Bult, A, Beijnen, J.H

“…A reversed-phase high-performance liquid chromatographic method has been developed and validated for the quantification of the novel anticancer drug…”
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