Search Results - "Hennigan, Robert"

Merlin tumor suppressor function is regulated by PIP2-mediated dimerization by Hennigan, Robert F, Thomson, Craig S, Stachowski, Kye, Nassar, Nicolas, Ratner, Nancy

“…Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member…”
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MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK by Na, Youjin, Hall, Ashley, Choi, Kwangmin, Hu, Liang, Rose, Jonathan, Coover, Robert A., Miller, Adam, Hennigan, Robert F., Dombi, Eva, Kim, Mi-Ok, Subramanian, Subbaya, Ratner, Nancy, Wu, Jianqiang

“…MicroRNAs (miRs) are small non-coding RNAs that can have large impacts on oncogenic pathways. Possible functions of dysregulated miRs have not been studied in…”
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FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function by Mani, Timmy, Hennigan, Robert F., Foster, Lauren A., Conrady, Deborah G., Herr, Andrew B., Ip, Wallace

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DEK over-expression promotes mitotic defects and micronucleus formation by Matrka, Marie C, Hennigan, Robert F, Kappes, Ferdinand, DeLay, Monica L, Lambert, Paul F, Aronow, Bruce J, Wells, Susanne I

“…The DEK gene encodes a nuclear protein that binds chromatin and is involved in various fundamental nuclear processes including transcription, RNA splicing, DNA…”
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Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions by Yoon, Sang Sun, Coakley, Ray, Lau, Gee W, Lymar, Sergei V, Gaston, Benjamin, Karabulut, Ahmet C, Hennigan, Robert F, Hwang, Sung-Hei, Buettner, Garry, Schurr, Michael J, Mortensen, Joel E, Burns, Jane L, Speert, David, Boucher, Richard C, Hassett, Daniel J

“…Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics…”
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Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1 by Coover, Robert A, Healy, Tabitha E, Guo, Li, Chaney, Katherine E, Hennigan, Robert F, Thomson, Craig S, Aschbacher-Smith, Lindsey E, Jankowski, Michael P, Ratner, Nancy

“…Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve…”
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Pseudomonas aeruginosa Anaerobic Respiration in Biofilms : Relationships to Cystic Fibrosis Pathogenesis by Yoon, Sang Sun, Hennigan, Robert F., Hilliard, George M., Ochsner, Urs A., Parvatiyar, Kislay, Kamani, Moneesha C., Allen, Holly L., DeKievit, Teresa R., Gardner, Paul R., Schwab, Ute, Rowe, John J., Iglewski, Barbara H., McDermott, Timothy R., Mason, Ronald P., Wozniak, Daniel J., Hancock, Robert E.W., Parsek, Matthew R., Noah, Terry L., Boucher, Richard C., Hassett, Daniel J.

“…Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation…”
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Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes by Hennigan, Robert F., Foster, Lauren A., Chaiken, Mary F., Mani, Timmy, Gomes, Michelle M., Herr, Andrew B., Ip, Wallace

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Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration by Yoon, Sang Sun, Karabulut, Ahmet C, Lipscomb, John D, Hennigan, Robert F, Lymar, Sergei V, Groce, Stephanie L, Herr, Andrew B, Howell, Michael L, Kiley, Patricia J, Schurr, Michael J, Gaston, Benjamin, Choi, Kyoung-Hee, Schweizer, Herbert P, Hassett, Daniel J

“…Protection from NO gas, a toxic byproduct of anaerobic respiration in Pseudomonas aeruginosa, is mediated by nitric oxide (NO) reductase (NOR), the norCB gene…”
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Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways by BAHASSI, El Mustapha, CONN, Christopher W, MYER, David L, HENNIGAN, Robert F, MCGOWAN, Clare H, SANCHEZ, Yolanda, STAMBROOK, Peter J

“…The Polo-like kinases (Plks) are a conserved family of kinases that contribute to cell cycle regulation, particularly in G2 and mitosis. In mammals, there are…”
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RB signaling prevents replication‐dependent DNA double‐strand breaks following genotoxic insult by Bosco, Emily E., Mayhew, Christopher N., Hennigan, Robert F., Sage, Julien, Jacks, Tyler, Knudsen, Erik S.

“…Cell cycle checkpoints induced by DNA damage play an integral role in preservation of genomic stability by allowing cells to limit the propagation of…”
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G Protein-induced Trafficking of Voltage-dependent Calcium Channels by Tombler, Eugene, Cabanilla, Nory Jun, Carman, Paul, Permaul, Natasha, Hall, John J., Richman, Ryan W., Lee, Jessica, Rodriguez, Jennifer, Felsenfeld, Dan P., Hennigan, Robert F., Diversé-Pierluissi, María A.

“…Calcium channels are well known targets for inhibition by G protein-coupled receptors, and multiple forms of inhibition have been described. Here we report a…”
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Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation by MUSTAPHA BAHASSI, E. L, HENNIGAN, Robert F, MYER, David L, STAMBROOK, Peter J

“…Mitosis in human cells is initiated at the end of G2 by activation of the Cdc2/cyclin B complex. Activation occurs by dephosphorylation of the inhibitory…”
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The Transcription Factor AP-1 Is Required for EGF-Induced Activation of Rho-Like GTPases, Cytoskeletal Rearrangements, Motility, and in vitro Invasion of A431 Cells by Malliri, Angeliki, Symons, Marc, Hennigan, Robert F., Adam F. L. Hurlstone, Lamb, Richard F., Wheeler, Tricia, Ozanne, Bradford W.

“…Human squamous cell carcinomas (SCC) frequently express elevated levels of epidermal growth factor receptor (EGFR). EGFR overexpression in SCC-derived cell…”
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Invasion is a genetic program regulated by transcription factors by Ozanne, Bradford W, Spence, Heather J, McGarry, Lynn C, Hennigan, Robert F

“…The invasive and metastatic behaviour of tumours impacts crucially on the clinical management of cancer. Accordingly, it is important to understand the…”
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Point mutation in the NF2 gene of HEI-193 human schwannoma cells results in the expression of a merlin isoform with attenuated growth suppressive activity by Lepont, Pierig, Stickney, John T, Foster, Lauren A, Meng, Jin-Jun, Hennigan, Robert F, Ip, Wallace

“…Neurofibromatosis type 2 (NF2) is a genetic disorder characterized by the formation of bilateral schwannomas of the eighth cranial nerve. Although the protein…”
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Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3 by CONN, Christopher W, HENNIGAN, Robert F, WEI DAI, SANCHEZ, Yolanda, STAMBROOK, Peter J

“…The polo-like kinases (Plks) are a family of conserved serine/threonine kinases that play a critical role in the normal progression of cells through mitosis…”
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Retinoblastoma Tumor Suppressor: Analyses of Dynamic Behavior in Living Cells Reveal Multiple Modes of Regulation by Angus, Steven P., Solomon, David A., Kuschel, Lioba, Hennigan, Robert F., Knudsen, Erik S.

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Critical regulation of genes for tumor cell migration by AP-1 by Bahassi, El Mustapha, Karyala, Saikumar, Tomlinson, Craig R, Sartor, Maureen A, Medvedovic, Mario, Hennigan, Robert F

“…The AP-1 transcription factor plays a critical role in regulating tumor cell proliferation and has been implicated in controlling a program of gene expression…”
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A FRET-based approach for studying conformational changes of a cytoskeleton-related tumor suppressor molecule by Hennigan, Robert F, Chaiken, Mary F, Foster, Lauren A, Ip, Wallace

“…Changes in conformation are an important regulatory mechanism for a wide variety of proteins. Proteins whose activity must change in response to external…”
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