Search Results - "Hennig, Krista M"

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease by Kilgore, Mark, Miller, Courtney A, Fass, Daniel M, Hennig, Krista M, Haggarty, Stephen J, Sweatt, J David, Rumbaugh, Gavin

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by cognitive impairments that progress to dementia and death. The earliest…”
Get full text

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia by Rosenthal, Zachary C., Fass, Daniel M., Payne, N. Connor, She, Angela, Patnaik, Debasis, Hennig, Krista M., Tesla, Rachel, Werthmann, Gordon C., Guhl, Charlotte, Reis, Surya A., Wang, Xiaoyu, Chen, Yueting, Placzek, Michael, Williams, Noelle S., Hooker, Jacob, Herz, Joachim, Mazitschek, Ralph, Haggarty, Stephen J.

“…Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN…”
Get full text

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
Get full text

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth by Hennig, Krista M, Colombani, Julien, Neufeld, Thomas P

“…Target of rapamycin (TOR) is a central regulator of cellular and organismal growth in response to nutrient conditions. In a genetic screen for novel TOR…”
Get full text

An epigenetic blockade of cognitive functions in the neurodegenerating brain by Gräff, Johannes, Rei, Damien, Guan, Ji-Song, Wang, Wen-Yuan, Seo, Jinsoo, Hennig, Krista M., Nieland, Thomas J. F., Fass, Daniel M., Kao, Patricia F., Kahn, Martin, Su, Susan C., Samiei, Alireza, Joseph, Nadine, Haggarty, Stephen J., Delalle, Ivana, Tsai, Li-Huei

“…Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and…”
Get full text

Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila by Hennig, Krista M., Neufeld, Thomas P.

Get full text

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors by Wagner, Florence F., Weïwer, Michel, Steinbacher, Stefan, Schomburg, Adrian, Reinemer, Peter, Gale, Jennifer P., Campbell, Arthur J., Fisher, Stewart L., Zhao, Wen-Ning, Reis, Surya A., Hennig, Krista M., Thomas, Méryl, Müller, Peter, Jefson, Martin R., Fass, Daniel M., Haggarty, Stephen J., Zhang, Yan-Ling, Holson, Edward B.

“…[Display omitted] The structure–activity and structure–kinetic relationships of a series of novel and selective ortho-aminoanilide inhibitors of histone…”
Get full text

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity by Fass, Daniel M., Reis, Surya A., Ghosh, Balaram, Hennig, Krista M., Joseph, Nadine F., Zhao, Wen-Ning, Nieland, Thomas J.F., Guan, Ji-Song, Groves Kuhnle, Chelsea E., Tang, Weiping, Barker, Douglas D., Mazitschek, Ralph, Schreiber, Stuart L., Tsai, Li-Huei, Haggarty, Stephen J.

“…Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the…”
Get full text

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4 by Hennig, Krista M, Fass, Daniel M, Zhao, Wen-Ning, Sheridan, Steven D, Fu, Ting, Erdin, Serkan, Stortchevoi, Alexei, Lucente, Diane, Cody, Jannine D, Sweetser, David, Gusella, James F, Talkowski, Michael E, Haggarty, Stephen J

“…Genetic variation within the transcription factor locus can cause the intellectual disability and developmental disorder Pitt-Hopkins syndrome (PTHS), whereas…”
Get full text

The mitochondrial multi-omic response to exercise training across rat tissues by Amar, David, Gay, Nicole R, Jimenez-Morales, David, Jean Beltran, Pierre M, Ramaker, Megan E, Raja, Archana Natarajan, Zhao, Bingqing, Sun, Yifei, Marwaha, Shruti, Gaul, David A, Hershman, Steven G, Ferrasse, Alexis, Xia, Ashley, Lanza, Ian, Fernández, Facundo M, Montgomery, Stephen B, Hevener, Andrea L, Ashley, Euan A, Walsh, Martin J, Sparks, Lauren M, Burant, Charles F, Rector, R Scott, Thyfault, John, Wheeler, Matthew T, Goodpaster, Bret H, Coen, Paul M, Schenk, Simon, Bodine, Sue C, Lindholm, Malene E

“…Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic…”
Get more information

The impact of exercise on gene regulation in association with complex trait genetics by Vetr, Nikolai G., Gay, Nicole R., Montgomery, Stephen B.

“…Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study…”
Get full text

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue by Many, Gina M., Sanford, James A., Sagendorf, Tyler J., Hou, Zhenxin, Nigro, Pasquale, Whytock, Katie L., Amar, David, Caputo, Tiziana, Gay, Nicole R., Gaul, David A., Hirshman, Michael F., Jimenez-Morales, David, Lindholm, Malene E., Muehlbauer, Michael J., Vamvini, Maria, Bergman, Bryan C., Fernández, Facundo M., Goodyear, Laurie J., Hevener, Andrea L., Ortlund, Eric A., Sparks, Lauren M., Xia, Ashley, Adkins, Joshua N., Bodine, Sue C., Newgard, Christopher B., Schenk, Simon

“…Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise…”
Get full text

Inhibitors of Class I Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease by KILGORE, Mark, MILLER, Courtney A, FASS, Daniel M, HENNIG, Krista M, HAGGARTY, Stephen J, SWEATT, J. David, RUMBAUGH, Gavin

Get full text

TOR Coordinates Bulk and Targeted Endocytosis in the Drosophila melanogoster Fat Body to Regulate Cell Growth by Krista M. Hennig, Colombani, Julien, Neufeld, Thomas P.

“…Target of rapamycin (TOR) is a central regulator of cellular and organismal growth in response to nutrient conditions. In a genetic screen for novel TOR…”
Get full text

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests. e71323 by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
Get full text