Search Results - "Hennig, Krista"

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease by Kilgore, Mark, Miller, Courtney A, Fass, Daniel M, Hennig, Krista M, Haggarty, Stephen J, Sweatt, J David, Rumbaugh, Gavin

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by cognitive impairments that progress to dementia and death. The earliest…”
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An epigenetic blockade of cognitive functions in the neurodegenerating brain by Gräff, Johannes, Rei, Damien, Guan, Ji-Song, Wang, Wen-Yuan, Seo, Jinsoo, Hennig, Krista M., Nieland, Thomas J. F., Fass, Daniel M., Kao, Patricia F., Kahn, Martin, Su, Susan C., Samiei, Alireza, Joseph, Nadine, Haggarty, Stephen J., Delalle, Ivana, Tsai, Li-Huei

“…Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and…”
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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia by Rosenthal, Zachary C., Fass, Daniel M., Payne, N. Connor, She, Angela, Patnaik, Debasis, Hennig, Krista M., Tesla, Rachel, Werthmann, Gordon C., Guhl, Charlotte, Reis, Surya A., Wang, Xiaoyu, Chen, Yueting, Placzek, Michael, Williams, Noelle S., Hooker, Jacob, Herz, Joachim, Mazitschek, Ralph, Haggarty, Stephen J.

“…Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN…”
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TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth by Hennig, Krista M, Colombani, Julien, Neufeld, Thomas P

“…Target of rapamycin (TOR) is a central regulator of cellular and organismal growth in response to nutrient conditions. In a genetic screen for novel TOR…”
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Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia by She, Angela, Kurtser, Iren, Reis, Surya A, Hennig, Krista, Lai, Jenny, Lang, Audrey, Zhao, Wen-Ning, Mazitschek, Ralph, Dickerson, Bradford C, Herz, Joachim, Haggarty, Stephen J

“…Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include…”
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Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors by Wagner, Florence F., Weïwer, Michel, Steinbacher, Stefan, Schomburg, Adrian, Reinemer, Peter, Gale, Jennifer P., Campbell, Arthur J., Fisher, Stewart L., Zhao, Wen-Ning, Reis, Surya A., Hennig, Krista M., Thomas, Méryl, Müller, Peter, Jefson, Martin R., Fass, Daniel M., Haggarty, Stephen J., Zhang, Yan-Ling, Holson, Edward B.

“…[Display omitted] The structure–activity and structure–kinetic relationships of a series of novel and selective ortho-aminoanilide inhibitors of histone…”
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Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity by Fass, Daniel M., Reis, Surya A., Ghosh, Balaram, Hennig, Krista M., Joseph, Nadine F., Zhao, Wen-Ning, Nieland, Thomas J.F., Guan, Ji-Song, Groves Kuhnle, Chelsea E., Tang, Weiping, Barker, Douglas D., Mazitschek, Ralph, Schreiber, Stuart L., Tsai, Li-Huei, Haggarty, Stephen J.

“…Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the…”
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Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin by Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J

“…Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a…”
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Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila by Hennig, Krista M., Neufeld, Thomas P.

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The Three-Dimensional Structure of the Autoproteolytic, Nuclear Pore-Targeting Domain of the Human Nucleoporin Nup98 by Hodel, Alec E, Hodel, Mary R, Griffis, Eric R, Hennig, Krista A, Ratner, Gary A, Xu, Songli, Powers, Maureen A

“…Nup98 is a component of the nuclear pore that plays its primary role in the export of RNAs. Nup98 is expressed in two forms, derived from alternate mRNA…”
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WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4 by Hennig, Krista M, Fass, Daniel M, Zhao, Wen-Ning, Sheridan, Steven D, Fu, Ting, Erdin, Serkan, Stortchevoi, Alexei, Lucente, Diane, Cody, Jannine D, Sweetser, David, Gusella, James F, Talkowski, Michael E, Haggarty, Stephen J

“…Genetic variation within the transcription factor locus can cause the intellectual disability and developmental disorder Pitt-Hopkins syndrome (PTHS), whereas…”
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The mitochondrial multi-omic response to exercise training across rat tissues by Amar, David, Gay, Nicole R, Jimenez-Morales, David, Jean Beltran, Pierre M, Ramaker, Megan E, Raja, Archana Natarajan, Zhao, Bingqing, Sun, Yifei, Marwaha, Shruti, Gaul, David A, Hershman, Steven G, Ferrasse, Alexis, Xia, Ashley, Lanza, Ian, Fernández, Facundo M, Montgomery, Stephen B, Hevener, Andrea L, Ashley, Euan A, Walsh, Martin J, Sparks, Lauren M, Burant, Charles F, Rector, R Scott, Thyfault, John, Wheeler, Matthew T, Goodpaster, Bret H, Coen, Paul M, Schenk, Simon, Bodine, Sue C, Lindholm, Malene E

“…Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic…”
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The impact of exercise on gene regulation in association with complex trait genetics by Vetr, Nikolai G., Gay, Nicole R., Montgomery, Stephen B.

“…Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study…”
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Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue by Many, Gina M., Sanford, James A., Sagendorf, Tyler J., Hou, Zhenxin, Nigro, Pasquale, Whytock, Katie L., Amar, David, Caputo, Tiziana, Gay, Nicole R., Gaul, David A., Hirshman, Michael F., Jimenez-Morales, David, Lindholm, Malene E., Muehlbauer, Michael J., Vamvini, Maria, Bergman, Bryan C., Fernández, Facundo M., Goodyear, Laurie J., Hevener, Andrea L., Ortlund, Eric A., Sparks, Lauren M., Xia, Ashley, Adkins, Joshua N., Bodine, Sue C., Newgard, Christopher B., Schenk, Simon

“…Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise…”
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Class I HDAC imaging using [3H]CI-994 autoradiography by Wang, Yajie, Zhang, Yan-Ling, Hennig, Krista, Gale, Jennifer P., Hong, Yijia, Cha, Anna, Riley, Misha, Wagner, Florence, Haggarty, Stephen J., Holson, Edward, Hooker, Jacob

“…[ 3 H]CI-994, a radioactive isotopologue of the benzamide CI-994, a class I histone deacetylase inhibitor (HDACi), was evaluated as an autoradiography probe…”
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Inhibitors of Class I Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease by KILGORE, Mark, MILLER, Courtney A, FASS, Daniel M, HENNIG, Krista M, HAGGARTY, Stephen J, SWEATT, J. David, RUMBAUGH, Gavin

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A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests. e71323 by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
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Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin by Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J

“…Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a…”
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Overexpression analysis reveals novel growth regulators in the target of rapamycin signaling pathway by Hennig, Krista Maria

“…To survive, develop, and reproduce in fluctuating environmental conditions, living organisms must tightly couple cell growth and metabolism to nutrient…”
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