Search Results - "Hennig, K M"

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers by Wagner, F F, Zhang, Y-L, Fass, D M, Joseph, N, Gale, J P, Weïwer, M, McCarren, P, Fisher, S L, Kaya, T, Zhao, W-N, Reis, S A, Hennig, K M, Thomas, M, Lemercier, B C, Lewis, M C, Guan, J S, Moyer, M P, Scolnick, E, Haggarty, S J, Tsai, L-H, Holson, E B

“…Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop…”
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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancersElectronic supplementary information (ESI) available: Compound synthesis and characterization; 1HNMR spectra, HPLC or UPLC spectral traces; HDAC enzymatic assay protocol; IC50s for representative compounds for HDACs 1-9; full kinetic parameters for BRD4884 and BRD6688; progression and dissociation curves for BRD6688; pharmacokinetic graphs and parameters for representative compounds; kinetic selectivity profi by Wagner, F. F, Zhang, Y.-L, Fass, D. M, Joseph, N, Gale, J. P, Weïwer, M, McCarren, P, Fisher, S. L, Kaya, T, Zhao, W.-N, Reis, S. A, Hennig, K. M, Thomas, M, Lemercier, B. C, Lewis, M. C, Guan, J. S, Moyer, M. P, Scolnick, E, Haggarty, S. J, Tsai, L.-H, Holson, E. B

“…Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop…”
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Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers† †Electronic supplementary information (ESI) available: Compound synthesis and characterization; 1HNMR spectra, HPLC or UPLC spectral traces; HDAC enzymatic assay protocol; IC50s for representative compounds for HDACs 1–9; full kinetic parameters for BRD4884 and BRD6688; progression and dissociation curves for BRD6688; pharmacokinetic graphs and parameters for representative compounds; kinetic selectivity pr by Wagner, F. F., Zhang, Y.-L., Fass, D. M., Joseph, N., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., Reis, S. A., Hennig, K. M., Thomas, M., Lemercier, B. C., Lewis, M. C., Guan, J. S., Moyer, M. P., Scolnick, E., Haggarty, S. J., Tsai, L.-H., Holson, E. B.

“…Kinetically selective inhibitors of HDAC2 enhanced learning and memory in a CK-p25 mouse model of neurodegeneration. Aiming towards the development of novel…”
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Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila by Hennig, Krista M., Neufeld, Thomas P.

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HPV positive bronchopulmonary carcinomas in women with previous high-grade cervical intraepithelial neoplasia (CIN III) by Hennig, E M, Suo, Z, Karlsen, F, Holm, R, Thoresen, S, Nesland, J M

“…A significant higher incidence of some cancers, especially lung cancer, has been found in women with previous HPV-related (human papillomavirus) urogenital and…”
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