Search Results - "Hennebelle, Isabelle"
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Hospicells (ascites‐derived stromal cells) promote tumorigenicity and angiogenesis
Published in International journal of cancer (01-05-2010)“…The microenvironment is known to play a dominant role in cancer progression. Cells closely associated with tumoral cells, named hospicells, have been recently…”
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Population pharmacokinetics of erlotinib and its pharmacokinetic/pharmacodynamic relationships in head and neck squamous cell carcinoma
Published in European journal of cancer (1990) (01-09-2009)“…Abstract A clinical study was conducted to determine the safety and efficacy of neoadjuvant erlotinib treatment in patients with head and neck squamous cell…”
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Population Analysis of Erlotinib in Adults and Children Reveals Pharmacokinetic Characteristics as the Main Factor Explaining Tolerance Particularities in Children
Published in Clinical cancer research (15-07-2011)“…The aim of this pharmacokinetic-pharmacodynamic (PK-PD) analysis was to evaluate the pharmacologic characteristics of erlotinib and its main metabolite…”
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Contribution of apoptosis in the cytotoxicity of the oxaliplatin–irinotecan combination in the HT29 human colon adenocarcinoma cell line
Published in Biochemical pharmacology (15-10-2002)“…Interactions between the topoisomerase I inhibitor irinotecan (CPT-11) and the platinum derivative oxaliplatin (L-OHP) were investigated in HT29 colon cancer…”
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Assessment of efficacy of postinfusion tubing flushing in reducing risk of cytotoxic contamination
Published in American journal of health-system pharmacy (30-10-2020)“…Abstract Purpose Infusion of cytotoxic drugs carries the risk of occupational exposure of healthcare workers. Since disconnecting an infusion line is a source…”
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A Chemiluminescent Microplate Assay to Detect DNA Damage Induced by Genotoxic Treatments
Published in Analytical biochemistry (20-11-1995)“…A damaged DNA detection assay (3D assay) using plasmid DNA adsorbed on sensitized microplates as the substrate for anin vitrorepair reaction is presented. DNA…”
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Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5‐fluorouracil‐based therapy together with cetuximab–irinotecan
Published in British journal of clinical pharmacology (01-05-2012)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Previous pharmacogenetic studies have reported the potential predictive value of thymidylate synthase (TYMS)…”
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Unexpected high levels of vorinostat when combined with vinorelbine in patients with advanced cancer
Published in Current clinical pharmacology (01-11-2011)“…This study was a multi-centre, dose-escalation trial in patients with advanced cancers. Primary objective was to determine maximum tolerated dose (MTD) of…”
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In vivo and in vitro antitumor activity of oxaliplatin in combination with cetuximab in human colorectal tumor cell lines expressing different level of EGFR
Published in Cancer chemotherapy and pharmacology (01-06-2006)“…This study aimed to assess the effect of cetuximab (C225, Erbitux, a chimeric anti-epidermal growth factor receptor (EGFR) monoclonal antibody) in combination…”
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Gene expression profiling on pre- and post-erlotinib tumors from patients with head and neck squamous cell carcinoma
Published in Head & neck (01-06-2013)“…Background The purpose of our work was to identify genomic predictive markers of erlotinib response in patients with head and neck squamous cell carcinoma…”
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Ovarian ascites-derived Hospicells promote angiogenesis via activation of macrophages
Published in Cancer letters (29-12-2012)“…Abstract Within the microenvironment, Carcinoma-associated mesenchymal stem cells (Hospicells) are able to influence ovarian tumor development via, among…”
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Irreversible hepatotoxicity after administration of trabectedin to a pleiomorphic sarcoma patient with a rare ABCC2 polymorphism: a case report
Published in Pharmacogenomics (01-09-2013)“…We describe here the case of a 60-year old male patient treated for an extensive local progression of a pleiomorphic sarcoma on the right tibial crest with…”
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Dexamethasone as a probe for docetaxel clearance
Published in Cancer chemotherapy and pharmacology (01-09-2004)“…A pilot study was conducted in 23 patients in order to assess the correlation between docetaxel clearance (CL) and pharmacokinetics of dexamethasone…”
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Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
Published in Biochemical pharmacology (01-03-1998)“…CPT-11 (irinotecan) is a DNA topoisomerase I inhibitor active against metastatic colorectal carcinoma. We investigated, in a human colon carcinoma cell line,…”
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Sequence‐dependent activity of the irinotecan‐5FU combination in human colon‐cancer model HT‐29 in vitro and in vivo
Published in International journal of cancer (27-11-1997)“…Irinotecan, a DNA‐topoisomerase‐I inhibitor, is active against metastatic colon carcinoma. We investigated the effects of irinotecan and 5FU combinations in…”
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Schedule-dependent activity of topotecan in OVCAR-3 ovarian carcinoma xenograft : Pharmacokinetic and pharmacodynamic evaluation
Published in Clinical cancer research (01-10-2001)“…Topotecan is a topoisomerase (Topo) I inhibitor used in ovarian carcinoma chemotherapy. Topo I inhibitors are thought to be more cytotoxic using protracted…”
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Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo
Published in Anti-cancer drugs (01-10-2001)“…The in vitro and in vivo combination of oxaliplatin and irinotecan was investigated in a panel of four human colon cancer cell lines and their counterpart…”
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Schedule-dependent Activity of Topotecan in OVCAR-3 Ovarian Carcinoma Xenograft
Published in Clinical cancer research (01-10-2001)“…Topotecan is a topoisomerase (Topo) I inhibitor used in ovarian carcinoma chemotherapy. Topo I inhibitors are thought to be more cytotoxic using protracted…”
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Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity
Published in Anti-cancer drugs (01-07-2000)“…Irinotecan (CPT-11) is a topoisomerase I inhibitor commonly used in the treatment of colorectal tumors. It is a prodrug, converted to an active metabolite,…”
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