Search Results - "Hennah, W."

What is the genetic architecture of major psychiatric disorders? by Hennah, W., Gennarelli, M.

“…Taken as a whole, psychiatric disorders are considered as complex genetic disorders. There are clear genetic mutations and susceptibility factors to these…”
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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia by Teng, S, Thomson, P A, McCarthy, S, Kramer, M, Muller, S, Lihm, J, Morris, S, Soares, D C, Hennah, W, Harris, S, Camargo, L M, Malkov, V, McIntosh, A M, Millar, J K, Blackwood, D H, Evans, K L, Deary, I J, Porteous, D J, McCombie, W R

“…Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower…”
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DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan by Porteous, D J, Thomson, P A, Millar, J K, Evans, K L, Hennah, W, Soares, D C, McCarthy, S, McCombie, W R, Clapcote, S J, Korth, C, Brandon, N J, Sawa, A, Kamiya, A, Roder, J C, Lawrie, S M, McIntosh, A M, St Clair, D, Blackwood, D H

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DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder by Hennah, W, Thomson, P, McQuillin, A, Bass, N, Loukola, A, Anjorin, A, Blackwood, D, Curtis, D, Deary, I J, Harris, S E, Isometsä, E T, Lawrence, J, Lönnqvist, J, Muir, W, Palotie, A, Partonen, T, Paunio, T, Pylkkö, E, Robinson, M, Soronen, P, Suominen, K, Suvisaari, J, Thirumalai, S, Clair, D St, Gurling, H, Peltonen, L, Porteous, D

“…Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and…”
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Replication of 1q42 linkage in Finnish schizophrenia pedigrees by EKELUND, J, HENNAH, W, HIEKKALINNA, T, PARKER, A, MEYER, J, LÖNNQVIST, J, PELTONEN, L

“…Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over…”
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Association of DISC1 with autism and Asperger syndrome by Kilpinen, H, Ylisaukko-oja, T, Hennah, W, Palo, O M, Varilo, T, Vanhala, R, Nieminen-von Wendt, T, von Wendt, L, Paunio, T, Peltonen, L

“…The DISC1 gene at 1q42 has generated considerable interest in various psychiatric diseases, since a balanced translocation interrupting the gene was found to…”
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Gene expression changes related to immune processes associate with cognitive endophenotypes of schizophrenia by Ukkola-Vuoti, L., Torniainen-Holm, M., Ortega-Alonso, A., Sinha, V., Tuulio-Henriksson, A., Paunio, T., Lönnqvist, J., Suvisaari, J., Hennah, W.

“…Schizophrenia is a heterogeneous disorder characterized by a spectrum of symptoms and many different underlying causes. Thus, instead of using the broad…”
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708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits by Thomson, P A, Parla, J S, McRae, A F, Kramer, M, Ramakrishnan, K, Yao, J, Soares, D C, McCarthy, S, Morris, S W, Cardone, L, Cass, S, Ghiban, E, Hennah, W, Evans, K L, Rebolini, D, Millar, J K, Harris, S E, Starr, J M, MacIntyre, D J, McIntosh, A M, Watson, J D, Deary, I J, Visscher, P M, Blackwood, D H, McCombie, W R, Porteous, D J

“…A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and…”
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Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects by Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, Parker, Alex, Martin, Rory, Levitzky, Steve, Partonen, Timo, Meyer, Joanne, Lönnqvist, Jouko, Peltonen, Leena, Ekelund, Jesper

“…We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from…”
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A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia by HENNAH, W, TUULIO-HENRIKSSON, A, PAUNIO, T, EKELUND, J, VARILO, T, PARTONEN, T, CANNON, T. D, LÖNNQVIST, J, PELTONEN, L

“…We have previously reported evidence of linkage and association between markers on 1q42 and schizophrenia in a study sample of 498 multiply affected Finnish…”
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Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women by Harris, S E, Hennah, W, Thomson, P A, Luciano, M, Starr, J M, Porteous, D J, Deary, I J

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Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness by Hennah, William, Thomson, Pippa, Peltonen, Leena, Porteous, David

“…Schizophrenia and related disorders have a major genetic component, but despite much effort and many claims, few genes have been consistently replicated and…”
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Minimum Description Length Block Finder, a Method to Identify Haplotype Blocks and to Compare the Strength of Block Boundaries by Mannila, H., Koivisto, M., Perola, M., Varilo, T., Hennah, W., Ekelund, J., Lukk, M., Peltonen, L., Ukkonen, E.

“…We describe a new probabilistic method for finding haplotype blocks that is based on the use of the minimum description length (MDL) principle. We give a…”
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The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study by Dahoun, Tarik, Pardiñas, Antonio F, Veronese, Mattia, Bloomfield, Michael A P, Jauhar, Sameer, Bonoldi, Ilaria, Froudist-Walsh, Sean, Nosarti, Chiara, Korth, Carsten, Hennah, William, Walters, James, Prata, Diana, Howes, Oliver D

“…Abstract Whilst the role of the Disrupted-in-Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterization of its…”
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Psychiatric Genetic Testing - An emerging, interdisciplinary field by Degenhardt, F, Andreassen, O, Borg, I, Borglum, A, Cichon, S, Coviello, D, Czerski, PM, Demontis, D, Foley, C, Hennah, W, Koido, K, Lopez, LM, Mattheisen, M, McGhee, KA, McQuillin, A, Miu, A, Mors, O, Pojskic, L, Popovska-Jankovic, K, Tammimies, K

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Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia by Hennah, William, Varilo, Teppo, Paunio, Tiina, Peltonen, Leena

“…For more than a decade there has been intensive research into the genetic etiology of schizophrenia, yet it is only recently that the first findings of…”
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Minimum description length block finder, a method to identify haplotype blocks and to compare the strength of block boundaries by Warren, Stephen T

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Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory by Cannon, Tyrone D, Hennah, William, van Erp, Theo G. M, Thompson, Paul M, Lonnqvist, Jouko, Huttunen, Matti, Gasperoni, Timothy, Tuulio-Henriksson, Annamari, Pirkola, Tia, Toga, Arthur W, Kaprio, Jaakko, Mazziotta, John, Peltonen, Leena

“…CONTEXT Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms…”
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An MDL method for finding haplotype blocks and for estimating the strength of haplotype block boundaries by Koivisto, M, Perola, M, Varilo, T, Hennah, W, Ekelund, J, Lukk, M, Peltonen, L, Ukkonen, E, Mannila, H

“…We describe a new method for finding haplotype blocks based on the use of the minimum description length principle. We give a rigorous definition of the…”
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Association of Variants in DISC1 With Psychosis-Related Traits in a Large Population Cohort by Tomppo, Liisa, Hennah, William, Miettunen, Jouko, Järvelin, Marjo-Riitta, Veijola, Juha, Ripatti, Samuli, Lahermo, Päivi, Lichtermann, Dirk, Peltonen, Leena, Ekelund, Jesper

“…CONTEXT There is an abundance of data from human genetic studies and animal models that implies a role for the disrupted in schizophrenia 1 gene (DISC1) in the…”
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