Search Results - "Henn, Brenna"

Did Our Species Evolve in Subdivided Populations across Africa, and Why Does It Matter? by Scerri, Eleanor M.L., Thomas, Mark G., Manica, Andrea, Gunz, Philipp, Stock, Jay T., Stringer, Chris, Grove, Matt, Groucutt, Huw S., Timmermann, Axel, Rightmire, G. Philip, d’Errico, Francesco, Tryon, Christian A., Drake, Nick A., Brooks, Alison S., Dennell, Robin W., Durbin, Richard, Henn, Brenna M., Lee-Thorp, Julia, deMenocal, Peter, Petraglia, Michael D., Thompson, Jessica C., Scally, Aylwyn, Chikhi, Lounès

“…We challenge the view that our species, Homo sapiens, evolved within a single population and/or region of Africa. The chronology and physical diversity of…”
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Genomic ancestry of North Africans supports back-to-Africa migrations by Henn, Brenna M, Botigué, Laura R, Gravel, Simon, Wang, Wei, Brisbin, Abra, Byrnes, Jake K, Fadhlaoui-Zid, Karima, Zalloua, Pierre A, Moreno-Estrada, Andres, Bertranpetit, Jaume, Bustamante, Carlos D, Comas, David

“…North African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time and the extent of…”
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great human expansion by Henn, Brenna M, Cavalli-Sforza, L. L, Feldman, Marcus W

“…Genetic and paleoanthropological evidence is in accord that today’s human population is the result of a great demic (demographic and geographic) expansion that…”
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Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans by McManus, Kimberly F, Taravella, Angela M, Henn, Brenna M, Bustamante, Carlos D, Sikora, Martin, Cornejo, Omar E

“…The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine receptor crucial for the infection of red blood cells by…”
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Counter the weaponization of genetics research by extremists by Carlson, Jedidiah, Henn, Brenna M., Al-Hindi, Dana R., Ramachandran, Sohini

“…Geneticists must rethink how they conduct their research and how they communicate results. Geneticists must rethink how they conduct their research and how…”
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Localization of adaptive variants in human genomes using averaged one-dependence estimation by Sugden, Lauren Alpert, Atkinson, Elizabeth G., Fischer, Annie P., Rong, Stephen, Henn, Brenna M., Ramachandran, Sohini

“…Statistical methods for identifying adaptive mutations from population genetic data face several obstacles: assessing the significance of genomic outliers,…”
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Clarifying distinct models of modern human origins in Africa by Henn, Brenna M, Steele, Teresa E, Weaver, Timothy D

“…Accumulating genomic, fossil and archaeological data from Africa have led to a renewed interest in models of modern human origins. However, such discussions…”
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Predicting Environmental and Ecological Drivers of Human Population Structure by Pless, Evlyn, Eckburg, Anders M, Henn, Brenna M

“…Abstract Landscape, climate, and culture can all structure human populations, but few existing methods are designed to simultaneously disentangle among a large…”
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Cryptic distant relatives are common in both isolated and cosmopolitan genetic samples by Henn, Brenna M, Hon, Lawrence, Macpherson, J Michael, Eriksson, Nick, Saxonov, Serge, Pe'er, Itsik, Mountain, Joanna L

“…Although a few hundred single nucleotide polymorphisms (SNPs) suffice to infer close familial relationships, high density genome-wide SNP data make possible…”
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Estimating the mutation load in human genomes by Henn, Brenna M., Botigué, Laura R., Bustamante, Carlos D., Clark, Andrew G., Gravel, Simon

“…Key Points Millions of new genetic variants have been discovered through sequencing studies and deposited in human genomic databases. Many of these,…”
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A weakly structured stem for human origins in Africa by Ragsdale, Aaron P., Weaver, Timothy D., Atkinson, Elizabeth G., Hoal, Eileen G., Möller, Marlo, Henn, Brenna M., Gravel, Simon

“…Despite broad agreement that Homo sapiens originated in Africa, considerable uncertainty surrounds specific models of divergence and migration across the…”
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Distance from sub-Saharan Africa predicts mutational load in diverse human genomes by Henn, Brenna M., Botigué, Laura R., Peischl, Stephan, Dupanloup, Isabelle, Lipatov, Mikhail, Maples, Brian K., Martin, Alicia R., Musharoff, Shaila, Cann, Howard, Snyder, Michael P., Excoffier, Laurent, Kidd, Jeffrey M., Bustamante, Carlos D.

“…The Out-of-Africa (OOA) dispersal ∼50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population…”
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Rapid, global demographic expansions after the origins of agriculture by Gignoux, Christopher R, Henn, Brenna M, Mountain, Joanna L

“…The invention of agriculture is widely assumed to have driven recent human population growth. However, direct genetic evidence for population growth after…”
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Inferring recombination patterns in African populations by van Eeden, Gerald, Uren, Caitlin, Möller, Marlo, Henn, Brenna M

“…Abstract Although several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains…”
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Editorial overview: The history, geography and adaptation of human genes: A tribute to L. Luca Cavalli-Sforza by Henn, Brenna M, Quintana-Murci, Lluis

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Trends in DNA Methylation with Age Replicate Across Diverse Human Populations by Gopalan, Shyamalika, Carja, Oana, Fagny, Maud, Patin, Etienne, Myrick, Justin W, McEwen, Lisa M, Mah, Sarah M, Kobor, Michael S, Froment, Alain, Feldman, Marcus W, Quintana-Murci, Lluis, Henn, Brenna M

“…Aging is associated with widespread changes in genome-wide patterns of DNA methylation. Thousands of CpG sites whose tissue-specific methylation levels are…”
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Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries by Uren, Caitlin, Kim, Minju, Martin, Alicia R, Bobo, Dean, Gignoux, Christopher R, van Helden, Paul D, Möller, Marlo, Hoal, Eileen G, Henn, Brenna M

“…Recent genetic studies have established that the KhoeSan populations of southern Africa are distinct from all other African populations and have remained…”
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Impact of cross-ancestry genetic architecture on GWASs in admixed populations by Mester, Rachel, Hou, Kangcheng, Ding, Yi, Meeks, Gillian, Burch, Kathryn S., Bhattacharya, Arjun, Henn, Brenna M., Pasaniuc, Bogdan

“…Genome-wide association studies (GWASs) have identified thousands of variants for disease risk. These studies have predominantly been conducted in individuals…”
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Gene flow from North Africa contributes to differential human genetic diversity in southern Europe by Botigué, Laura R., Henn, Brenna M., Gravel, Simon, Maples, Brian K., Gignoux, Christopher R., Corona, Erik, Atzmon, Gil, Burns, Edward, Ostrer, Harry, Flores, Carlos, Bertranpetit, Jaume, Comas, David, Bustamante, Carlos D.

“…Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the…”
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Hunter-gatherer genomes reveal diverse demographic trajectories during the rise of farming in Eastern Africa by Gopalan, Shyamalika, Berl, Richard E.W., Myrick, Justin W., Garfield, Zachary H., Reynolds, Austin W., Bafens, Barnabas K., Belbin, Gillian, Mastoras, Mira, Williams, Cole, Daya, Michelle, Negash, Akmel N., Feldman, Marcus W., Hewlett, Barry S., Henn, Brenna M.

“…The fate of hunting and gathering populations following the rise of agriculture and pastoralism remains a topic of debate in the study of human prehistory…”
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