Search Results - "Henkler, F"

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling by Wicovsky, A, Salzmann, S, Roos, C, Ehrenschwender, M, Rosenthal, T, Siegmund, D, Henkler, F, Gohlke, F, Kneitz, C, Wajant, H

“…Soluble TNF-like weak inducer of apoptosis (TWEAK) trimers induce, in a variety of cell lines, translocation of cytosolic tumor necrosis factor (TNF)…”
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Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation by Wicovsky, A, Henkler, F, Salzmann, S, Scheurich, P, Kneitz, C, Wajant, H

“…It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of…”
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Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291 by Tkachenko, A., Bermudez, M., Irmer-Stooff, S., Genkinger, D., Henkler-Stephani, F., Wolber, G., Luch, A.

“…The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor involved in the metabolism of physiological substances and xenobiotics,…”
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Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis by Geserick, P, Drewniok, C, Hupe, M, Haas, T L, Diessenbacher, P, Sprick, M R, Schön, M P, Henkler, F, Gollnick, H, Walczak, H, Leverkus, M

“…Death ligands such as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and certain forms of CD95L are attractive therapeutic options for…”
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Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis by Stolpmann, K, Brinkmann, J, Salzmann, S, Genkinger, D, Fritsche, E, Hutzler, C, Wajant, H, Luch, A, Henkler, F

“…In this study, we have analysed the apoptotic effects of the ubiquitous environmental toxin benzo[ a ]pyrene (BP) in HaCaT cells and human keratinocytes…”
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Intracellular localization of the hepatitis B virus HBx protein by Henkler, Frank, Hoare, Jonathan, Waseem, Naushin, Goldin, Robert D, McGarvey, Michael J, Koshy, Rajen, King, Ian A

“…National Institute for Medical Research, Division of Membrane Biology, The Ridgeway, Mill Hill, London NW7 1AA, UK 1 Department of Medicine 2 and Department of…”
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Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation by Wicovsky, A, Henkler, F, Salzmann, S, Scheurich, P, Kneitz, C, Wajant, H

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Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesis by Henkler F, F, Koshy, R

“…The hepatitis B virus (HBV) genome encodes a 154 amino acid protein termed X (HBx, hepatitis B x protein), which is a promiscuous transcriptional activator of…”
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Trangenic Misexpression of the Differentiation-Specific Desmocollin Isoform 1 in Basal Keratinocytes by Henkler, Frank, Strom, Molly, Mathers, Kathleen, Cordingley, Hayley, Sullivan, Kate, King, Ian

“…Keratinocytes undergoing terminal differentiation are characterized by well-defined changes in protein expression, which contribute towards the transformation…”
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Adverse health effects of environmental chemical agents through non-genotoxic mechanisms by Henkler, Frank, Luch, Andreas

“…Many of these compounds are now suspected or have already been demonstrated to be capable of modulating cellular receptor responses involved in physiological…”
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The TNF-receptor-associated factor family: Scaffold molecules for cytokine receptors, kinases and their regulators by Wajant, Harald, Henkler, Frank, Scheurich, Peter

“…The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF…”
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Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8 by Fotin-Mleczek, Mariola, Henkler, Frank, Samel, Dierk, Reichwein, Monica, Hausser, Angelika, Parmryd, Ingela, Scheurich, Peter, Schmid, Johannes A, Wajant, Harald

“…We have recently shown that stimulation of TNF-R2 selectively enhances apoptosis induction by the death receptor TNF-R1. Here, we demonstrate that stimulation…”
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Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-κB Activation by Fotin-Mleczek, Mariola, Henkler, Frank, Hausser, Angelika, Glauner, Heike, Samel, Dierk, Graness, Angela, Scheurich, Peter, Mauri, Davide, Wajant, Harald

“…To investigate CD40 signaling complex formation in living cells, we used green fluorescent protein (GFP)-tagged CD40 signaling intermediates and confocal life…”
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extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability by Henkler, Frank, Behrle, Eva, Dennehy, Kevin M, Wicovsky, Andreas, Peters, Nathalie, Warnke, Clemens, Pfizenmaier, Klaus, Wajant, Harald

“…Using fluorescent variants of Fas and FasL, we show that membrane FasL and Fas form supramolecular clusters that are of flexible shape, but nevertheless stable…”
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Erratum: Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation by Wicovsky, A, Henkler, F, Salzmann, S, Scheurich, P, Kneitz, C, Wajant, H

“…Correction to: Oncogene (2009) 28, 1769–1781; doi:10.1038/onc.2009.29; published online 16 March 2009 The authors found that the Colo205 cells used were…”
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p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells by Bartke, Till, Siegmund, Daniela, Peters, Nathalie, Reichwein, Monica, Henkler, Frank, Scheurich, Peter, Wajant, Harald

“…One of the main functions of the tumor suppressor p53 is the induction of programmed cell death. Here we investigated in detail the molecular mechanisms that…”
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Polycyclic aromatic hydrocarbons in consumer products—Metabolism and toxicity in human skin by Stolpmann, Kristin, Henkler, Frank, Hutzler, Christoph, Desai, Dhimant, Amin, Shantu, Luch, Andreas

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Caspase-mediated Cleavage Converts the Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-1 from a Selective Modulator of TNF Receptor Signaling to a General Inhibitor of NF-κB Activation by Henkler, Frank, Baumann, Bernd, Fotin-Mleczek, Mariola, Weingärtner, Monika, Schwenzer, Ralph, Peters, Nathalie, Graness, Angela, Wirth, Thomas, Scheurich, Peter, Schmid, Johannes A., Wajant, Harald

“…The role of tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 in NF-κB activation by various members of the TNF receptor family is not well…”
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Subcellular localisation of the X protein in HBV infected hepatocytes by Hoare, Jonathan, Henkler, Frank, Dowling, Jason J., Errington, William, Goldin, Robert D., Fish, David, McGarvey, Michael J.

“…Hepatitis B virus X protein (HBx) is a multifunctional protein that exerts its effects primarily by acting as a transcriptional transactivator of viral and…”
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Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells by Groisman, Iris Jaitovich, Koshy, Rajen, Henkler, Frank, Groopman, John D., Alaoui-Jamali, Moulay A.

“…Synergism between exposure to chemical carcinogens and infection with the hepatitis B virus (HBV) has been implicated in the high incidence of hepatocellular…”
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