Search Results - "Henkel, Janin"

Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle by Bishop, Christopher A., Machate, Tina, Henning, Thorsten, Henkel, Janin, Püschel, Gerhard, Weber, Daniela, Grune, Tilman, Klaus, Susanne, Weitkunat, Karolin

“…Objective Current data regarding the roles of branched-chain amino acids (BCAA) in metabolic health are rather conflicting, as positive and negative effects…”
Get full text

Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model by Henkel, Janin, Coleman, Charles Dominic, Schraplau, Anne, Jöhrens, Korinna, Weiss, Thomas Siegfried, Jonas, Wenke, Schürmann, Annette, Püschel, Gerhard Paul

“…In a subset of patients, non-alcoholic fatty liver disease (NAFLD) is complicated by cell death and inflammation resulting in non-alcoholic steatohepatitis…”
Get full text

Insulin-induced cytokine production in macrophages causes insulin resistance in hepatocytes by Manowsky, Julia, Camargo, Rodolfo Gonzalez, Kipp, Anna P, Henkel, Janin, Püschel, Gerhard P

“…Overweight and obesity are associated with hyperinsulinemia, insulin resistance, and a low-grade inflammation. Although hyperinsulinemia is generally thought…”
Get more information

Heptadecanoic Acid Is Not a Key Mediator in the Prevention of Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice by Bishop, Christopher A, Machate, Tina, Henkel, Janin, Schulze, Matthias B, Klaus, Susanne, Piepelow, Karolin

“…Epidemiological studies found that the intake of dairy products is associated with an increased amount of circulating odd-chain fatty acids (OCFA, C15:0 and…”
Get full text

Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype by Fayyaz, Susann, Henkel, Janin, Japtok, Lukasz, Krämer, Stephanie, Damm, Georg, Seehofer, Daniel, Püschel, Gerhard P., Kleuser, Burkhard

“…Aims/hypothesis Enhanced plasma levels of NEFA have been shown to induce hepatic insulin resistance, which contributes to the development of type 2 diabetes…”
Get full text

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol by Henkel, Janin, Coleman, Charles Dominic, Schraplau, Anne, Jöhrens, Korinna, Weber, Daniela, Castro, José Pedro, Hugo, Martin, Schulz, Tim Julius, Krämer, Stephanie, Schürmann, Annette, Püschel, Gerhard Paul

“…Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used…”
Get full text

Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol by Henkel, Janin, Alfine, Eugenia, Saín, Juliana, Jöhrens, Korinna, Weber, Daniela, Castro, José P, König, Jeannette, Stuhlmann, Christin, Vahrenbrink, Madita, Jonas, Wenke, Kleinridders, André, Püschel, Gerhard P

“…While the impact of dietary cholesterol on the progression of atherosclerosis has probably been overestimated, increasing evidence suggests that dietary…”
Get full text

Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action by Schell, Mareike, Chudoba, Chantal, Leboucher, Antoine, Alfine, Eugenia, Flore, Tanina, Ritter, Katrin, Weiper, Katharina, Wernitz, Andreas, Henkel, Janin, Kleinridders, André

“…Overconsumption of high-fat and cholesterol-containing diets is detrimental for metabolism and mitochondrial function, causes inflammatory responses and…”
Get full text

Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH by Henkel, Janin, Buchheim-Dieckow, Katja, Castro, José P, Laeger, Thomas, Wardelmann, Kristina, Kleinridders, André, Jöhrens, Korinna, Püschel, Gerhard P

“…Non-alcoholic fatty liver diseases (NAFLD) including the severe form with steatohepatitis (NASH) are highly prevalent ailments to which no approved…”
Get full text

The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes by NEUSCHÄFER-RUBE, Frank, LIESKE, Stefanie, TOLKACHOV, Alexander, SCHUPP, Michael, PATHE-NEUSCHÄFER-RUBE, Andrea, PFEIFFER, Andreas F. H, SHUTMAN, Gerald I, PUSCHEL, Gerhard P, BIRKENFELD, Andreas L, KUNA, Manuela, HENKEL, Janin, PERRY, Rachel J, ERION, Derek M, PESTA, Dominik, WILLMES, Diana M, BRACHS, Sebastian, VON LOEFFELHOLZ, Christian

“…Reduced expression of the INDY (I'm not dead yet) tricarboxylate carrier increased the life span in different species by mechanisms akin to caloric…”
Get full text

Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E2 by Henkel, Janin, Klauder, Julia, Statz, Meike, Wohlenberg, Anne-Sophie, Kuipers, Sonja, Vahrenbrink, Madita, Püschel, Gerhard Paul

“…Macrophages in pathologically expanded dysfunctional white adipose tissue are exposed to a mix of potential modulators of inflammatory response, including…”
Get full text

Aggravation by prostaglandin E2 of interleukin‐6‐dependent insulin resistance in hepatocytes by Henkel, Janin, Neuschäfer‐Rube, Frank, Pathe‐Neuschäfer‐Rube, Andrea, Püschel, Gerhard P.

“…Hepatic insulin resistance is a major contributor to fasting hyperglycemia in patients with metabolic syndrome and type 2 diabetes. Circumstantial evidence…”
Get full text

Characterization and optimization of microwave-assisted extraction of B-phycoerythrin from Porphyridium purpureum using response surface methodology and Doehlert design by Huschek, Gerd, Rawel, Harshadrai M., Schweikert, Torsten, Henkel-Oberländer, Janin, Sagu, Sorel Tchewonpi

Get full text

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases by Püschel, Gerhard Paul, Klauder, Julia, Henkel, Janin

“…Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia…”
Get full text

Direct and indirect modulation of LPS-induced cytokine production by insulin in human macrophages by Klauder, Julia, Henkel, Janin, Vahrenbrink, Madita, Wohlenberg, Anne-Sophie, Camargo, Rodolfo Gonzalez, Püschel, Gerhard Paul

“…•Insulin enhanced LPS-dependent cytokine and prostaglandin production in macrophages.•Prostaglandin E2 further amplified LPS- and insulin-mediated cytokine…”
Get full text

Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis by Henkel, Janin, Frede, Katja, Schanze, Nancy, Vogel, Heike, Schürmann, Annette, Spruss, Astrid, Bergheim, Ina, Püschel, Gerhard P

“…Hepatic steatosis is recognized as hepatic presentation of the metabolic syndrome. Hyperinsulinaemia, which shifts fatty acid oxidation to de novo lipogenesis…”
Get full text

Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response by Spruss, Astrid, Henkel, Janin, Kanuri, Giridhar, Blank, Daniela, Püschel, Gerhard P, Bischoff, Stephan C, Bergheim, Ina

“…As significant differences between sexes were found in the susceptibility to alcoholic liver disease in human and animal models, it was the aim of the present…”
Get full text

Oncostatin M produced in Kupffer cells in response to PGE : possible contributor to hepatic insulin resistance and steatosis

Get full text

Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E 2 by Henkel, Janin, Klauder, Julia, Statz, Meike, Wohlenberg, Anne-Sophie, Kuipers, Sonja, Vahrenbrink, Madita, Püschel, Gerhard Paul

“…Macrophages in pathologically expanded dysfunctional white adipose tissue are exposed to a mix of potential modulators of inflammatory response, including…”
Get full text

Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes by Neuschäfer-Rube, Frank, Schraplau, Anne, Schewe, Bettina, Lieske, Stefanie, Krützfeldt, Julia-Mignon, Ringel, Sebastian, Henkel, Janin, Birkenfeld, Andreas L., Püschel, Gerhard P.

“…[Display omitted] Non-alcoholic fatty liver disease is a growing problem in industrialized and developing countries. Hepatic lipid accumulation is the result…”
Get full text