Search Results - "Henkel, James G"

Structure-anti-Parkinson activity relationships in the aminoadamantanes. Influence of bridgehead substitution by Henkel, James G, Hane, Jeffrey T, Gianutsos, Gerald

“…A limited series of bridgehead alkyl-, dialkyl-, and trialkyl-substituted amantadines was synthesized and tested for potential anti-Parkinson activity as…”
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Studies in the 2,4-disubstituted adamantanes. Preparation and reactivity of pure epimeric 4-hydroxy- and 4-methoxyadamantan-2-ones by Henkel, James G, Spector, Joni H

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Neighboring group effects in the .beta.-halo amines. Synthesis and solvolytic reactivity of the anti-4-substituted 2-azaadamantyl system by Henkel, James G, Faith, William C

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Pharmacological activity of amantadine: effect of N-alkyl substitution by Dunn, J P, Henkel, J G, Gianutsos, G

“…Alkyl substitution on the nitrogen atom of the anti-parkinsonian drug amantadine resulted in changes in its pharmacological potency. Greater behavioural…”
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Nature of the carbonium ion. XI. 2-Homobrendyl cation by Henkel, James G, Spurlock, Langley A

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Methyl mercapturate episulfonium ion: a model reactive metabolite of dihaloethanes by Henkel, James G, Amato, George S

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Efficient synthesis of barbaralane by Henkel, James G, Hane, Jeffrey T

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General synthesis of N-substituted 2-azaadamantanes and their 4,8-disubstituted derivatives by Henkel, James G, Faith, William C, Hane, Jeffrey T

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Synthesis and adrenoceptor affinity of some highly polar .beta.-substituted catecholamines by Henkel, James G, Sikand, Neil, Makriyannis, Alexandros, Gianutsos, Gerald

“…In order to assess the potential for sympathomimetic or sympatholytic activity within the series of catecholamine beta-sulfonates 3a-c, alpha- and…”
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Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone diastereomers by Henkel, James G, Berg, Eric P, Portoghese, Philip S

“…The synthesis of racemic threo- and erythro-5-methylmethadone (3a and 3b, respectively) was carried out and the solution conformation of each isomer was…”
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Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance by Henkel, James G, Bell, Kevin H, Portoghese, Philip S

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Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine by Henkel, James G, Portoghese, Philip S, Miller, Jack W, Lewis, Patricia

“…Crystalline perchlorate salts of aziridinium ions derived from phenoxybenzamine and dibenamine were prepared. Both aziridinium ions were tested on the rat vas…”
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The Impact of Biotechnology upon Chemistry in Pharmacy Schools by Henkel, James G

“…Applications of biotechnology to the pharmaceutical industry are examined, and its impact on the research and practical domains of medicinal and natural…”
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PC-based molecular modeling in the classroom: applications to medicinal chemistry and biochemistry by Henkel, J G

“…Among the most difficult aspects of medicinal chemistry and biochemistry for the student to master are the three-dimensional (3D) nature of drugs and…”
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