Search Results - "Henkel, G. W."

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities by McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., Maki, R. A.

“…PU.1 is a member of the ets family of transcription factors and is expressed exclusively in cells of the hematopoietic lineage. Mice homozygous for a…”
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Defective trophoblast function in mice with a targeted mutation of Ets2 by Yamamoto, H, Flannery, M L, Kupriyanov, S, Pearce, J, McKercher, S R, Henkel, G W, Maki, R A, Werb, Z, Oshima, R G

“…Members of the Ets family of transcription factors mediate transcriptional responses of multiple signaling pathways in diverse cell types and organisms…”
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Differentiation of the Mononuclear Phagocyte System During Mouse Embryogenesis: The Role of Transcription Factor PU.1 by Lichanska, Agnieszka M., Browne, Catherine M., Henkel, Gregory W., Murphy, Kathleen M., Ostrowski, Michael C., McKercher, Scott R., Maki, Richard A., Hume, David A.

“…During mouse embryogenesis, macrophage-like cells arise first in the yolk sac and are produced subsequently in the liver. The onset of liver hematopoiesis is…”
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Identification of three genes up‐regulated in PU.1 rescued monocytic precursor cells by Henkel, Gregory W., McKercher, Scott R., Maki, Richard A.

“…The requirement of the transcription factor PU.1 for macrophage development has been well documented. However, the target genes regulated by PU.1 controlling…”
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Commitment to the Monocytic Lineage Occurs in the Absence of the Transcription Factor PU.1 by Henkel, Gregory W., McKercher, Scott R., Leenen, Pieter J.M., Maki, Richard A.

“…Mice homozygous for the disruption of the PU.1 (Spi-1) gene do not produce mature macrophages. In determining the role of PU.1 in macrophage differentiation,…”
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PU.1 But Not Ets-2 Is Essential for Macrophage Development From Embryonic Stem Cells by Henkel, Gregory W., McKercher, Scott R., Yamamoto, Hideyuki, Anderson, Karen L., Oshima, Robert G., Maki, Richard A.

“…Transcription factors play an important role choreographing lineage commitment and expansion of blood cells. Nuclear factors that are expressed primarily or…”
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The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects by McKercher, Scott R., Henkel, Gregory W., Maki, Richard A.

“…PU.1 is a transcription factor shown to regulate the expression of many important genes in myeloid and B cells. At birth, mice homozygous for the disruption of…”
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