Search Results - "Henkel, Anne S."

Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis by Olivares, Shantel, Henkel, Anne S.

“…Endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR), a highly conserved signaling cascade that functions to alleviate stress and…”
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The role of X-box binding protein 1 in the hepatic response to refeeding in mice by Olivares, Shantel, Henkel, Anne S.

“…Refeeding mice after a prolonged fast is a potent stimulus of hepatic lipogenesis, but is also associated with induction of the hepatic unfolded protein…”
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Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet by Liu, Xiaoying, Henkel, Anne S, LeCuyer, Brian E, Schipma, Matthew J, Anderson, Kristy A, Green, Richard M

“…Fatty liver is associated with endoplasmic reticulum stress and activation of the hepatic unfolded protein response (UPR). Reduced hepatic expression of the…”
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Endoplasmic reticulum stress activates the hepatic activator protein 1 complex via mitogen activated protein kinase-dependent signaling pathways by Olivares, Shantel, Green, Richard M, Henkel, Anne S

“…Endoplasmic reticulum (ER) stress is induced in many forms of chronic liver disease and may promote the development of hepatocellular carcinoma. The activator…”
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Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice by Liu, Xiaoying, Henkel, Anne S., LeCuyer, Brian E., Hubchak, Susan C., Schipma, Matthew J., Zhang, Eric, Green, Richard M.

“…The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1α/X-box binding protein 1…”
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Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice by Olivares, Shantel, Henkel, Anne S

“…Fibroblast growth factor 21 (FGF21), a key regulator of the metabolic response to fasting, is highly induced by endoplasmic reticulum (ER) stress. The X-box…”
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A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice[S] by Henkel, Anne S., Anderson, Kristy A., Dewey, Amanda M., Kavesh, Mark H., Green, Richard M.

“…Cholesterol 7α-hydroxylase (CYP7A1) encodes for the rate-limiting step in the conversion of cholesterol to bile acids in the liver. In response to acute…”
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Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice by Henkel, Anne S., Khan, Sadiya S., Olivares, Shantel, Miyata, Toshio, Vaughan, Douglas E.

“…Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such…”
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Homocysteine Supplementation Attenuates the Unfolded Protein Response in a Murine Nutritional Model of Steatohepatitis by Henkel, Anne S., Elias, Marc S., Green, Richard M.

“…Hyperhomocysteinemia has been correlated with hepatic steatosis and activation of the unfolded protein response (UPR), yet a causal relationship has not been…”
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Harnessing the Integrated Stress Response to Counteract Metabolic Disease by Henkel, Anne S.

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Unfolded Protein Response Sensors in Hepatic Lipid Metabolism and Nonalcoholic Fatty Liver Disease by Henkel, Anne S

“…Activation of the hepatic unfolded protein response (UPR), a highly conserved cellular response to endoplasmic reticulum (ER) stress, is a firmly established…”
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Genetic Disorders of Bile Acid Transport by Henkel, Anne S.

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Inhibition of PAI‐1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice by Levine, Joshua A., Olivares, Shantel, Miyata, Toshio, Vaughan, Douglas E., Henkel, Anne S.

“…Objective This study investigates the therapeutic potential of a small molecule inhibitor of plasminogen activator inhibitor‐1 (PAI‐1), TM5441, in reversing…”
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Endoplasmic reticulum stress induces hepatic plasminogen activator inhibitor 1 in murine nonalcoholic steatohepatitis by Olivares, Shantel, Henkel, Anne S.

“…Plasminogen activator inhibitor 1 (PAI‐1) is a stress‐responsive gene that is highly induced in nonalcoholic steatohepatitis (NASH). Endoplasmic reticulum (ER)…”
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Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice by Henkel, Anne S, LeCuyer, Brian, Olivares, Shantel, Green, Richard M

“…Background & Aims Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is…”
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Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet by Henkel, Anne S, Dewey, Amanda M, Anderson, Kristy A, Olivares, Shantel, Green, Richard M

“…Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of nonalcoholic steatohepatitis. The ER stress response is activated in the livers of…”
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Nutritional support in patients with chronic liver disease by Buchman, Alan L, Henkel, Anne S

“…Malnutrition is highly prevalent among patients with chronic liver disease and is nearly universal among patients awaiting liver transplantation. Malnutrition…”
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Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation by Henkel, Anne S, Gooijert, Karin E R, Havinga, Rick, Boverhof, Renze, Green, Richard M, Verkade, Henkjan J

“…The bile salt export pump, encoded by ABCB11, is the predominant canalicular transport protein for biliary bile acid secretion. The level of ABCB11 expression…”
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Single well, single-common primer pair, dual probe, duplex qPCR assay for the quantification of mRNA splicing variants by Wang, Janice, Wong, Winifred P, Link, Emma O, Olivares, Shantel, Adelman, Cade T, Henkel, Anne S, El Muayed, Malek

“…Abstract Quantifying the ratio of alternatively spliced mRNA variants of genes with known alternative splicing variants is highly relevant for many…”
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Hepatic Overexpression of Abcb11 Promotes Hypercholesterolemia and Obesity in Mice by Henkel, Anne S, Kavesh, Mark H, Kriss, Michael S, Dewey, Amanda M, Rinella, Mary E, Green, Richard M

“…Background & Aims ABCB11 is a canalicular transport protein that controls the rate-limiting step in hepatic bile acid secretion. Its expression levels vary in…”
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