Search Results - "Heninger, Erika"

Augmenting antitumor immune responses with epigenetic modifying agents by Héninger, Erika, Krueger, Timothy E G, Lang, Joshua M

“…Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that occurs in the process of tumorigenesis. This phenomena impacts…”
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Dynamic reciprocal interactions between activated T cells and tumor associated macrophages drive macrophage reprogramming and proinflammatory T cell migration within prostate tumor models by Heninger, Erika, Breneman, Matthew Thomas, Recchia, Emma Elizabeth, Kerr, Sheena Catherine, Dogru, Reyna Elvan, Sharifi, Marina Nasrin, LeBeau, Aaron Matthew, Kosoff, David

“…Tumor-associated macrophages (TAMs) have been implicated as a tumor microenvironment (TME) cell population, which may be playing a vital role in the inhibition…”
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TPL2 kinase regulates the inflammatory milieu of the myeloma niche by Hope, Chelsea, Ollar, Samuel J., Heninger, Erika, Hebron, Ellen, Jensen, Jeffrey L., Kim, Jaehyup, Maroulakou, Ioanna, Miyamoto, Shigeki, Leith, Catherine, Yang, David T., Callander, Natalie, Hematti, Peiman, Chesi, Marta, Bergsagel, P. Leif, Asimakopoulos, Fotis

“…Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we…”
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Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells by Nanjappa, Som Gowda, Heninger, Erika, Wüthrich, Marcel, Gasper, David Joseph, Klein, Bruce S

“…Vaccines may help reduce the growing incidence of fungal infections in immune-suppressed patients. We have found that, even in the absence of CD4(+) T-cell…”
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High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1 by Schehr, Jennifer L, Schultz, Zachery D, Warrick, Jay W, Guckenberger, David J, Pezzi, Hannah M, Sperger, Jamie M, Heninger, Erika, Saeed, Anwaar, Leal, Ticiana, Mattox, Kara, Traynor, Anne M, Campbell, Toby C, Berry, Scott M, Beebe, David J, Lang, Joshua M

“…Expression of programmed-death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) is typically evaluated through invasive biopsies; however, recent…”
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Development and initial clinical testing of a multiplexed circulating tumor cell assay in patients with clear cell renal cell carcinoma by Bade, Rory M., Schehr, Jennifer L., Emamekhoo, Hamid, Gibbs, Benjamin K., Rodems, Tamara S., Mannino, Matthew C., Desotelle, Joshua A., Heninger, Erika, Stahlfeld, Charlotte N., Sperger, Jamie M., Singh, Anupama, Wolfe, Serena K., Niles, David J., Arafat, Waddah, Steinharter, John A., Jason Abel, E., Beebe, David J., Wei, Xiao X., McKay, Rana R., Choueri, Toni K., Lang, Joshua M.

“…Although therapeutic options for patients with advanced renal cell carcinoma (RCC) have increased in the past decade, no biomarkers are yet available for…”
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Reversible epigenetic alterations regulate class I HLA loss in prostate cancer by Rodems, Tamara S., Heninger, Erika, Stahlfeld, Charlotte N., Gilsdorf, Cole S., Carlson, Kristin N., Kircher, Madison R., Singh, Anupama, Krueger, Timothy E. G., Beebe, David J., Jarrard, David F., McNeel, Douglas G., Haffner, Michael C., Lang, Joshua M.

“…Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer and may underlie the ineffectiveness of checkpoint…”
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220 Differential patterns of immune infiltration in the tumor immune microenvironment associate with therapeutic response in primary prostate cancer following chemohormonal therapy by Heninger, Erika, Sperger, Jamie, Weinstein, Kristin, Johnson, Brian, Geiger, Peter, Kerr, Sheena, Wells, Shane, Cho, Steve, Huang, Wei, Ong, Irene, Tsourkas, Philippos, Mcilwain, Sean J, Jarrard, David, Beebe, David, Lang, Joshua

“…BackgroundThere is a critical need to develop novel therapeutic strategies and diagnostic tools to precisely deliver treatments to improve survival for men…”
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Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS by Clarkson, Benjamin D, Héninger, Erika, Harris, Melissa G, Lee, JangEun, Sandor, Matyas, Fabry, Zsuzsanna

“…Dendritic cells (DCs) are a heterogeneous group of professional antigen presenting cells that lie in a nexus between innate and adaptive immunity because they…”
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Mycobacteria-Induced Suppression of Autoimmunity in the Central Nervous System by Lee, JangEun, Sandor, Matyas, Heninger, Erika, Fabry, Zsuzsanna

“…Mycobacterial suppression of central nervous system (CNS) autoimmunity has been demonstrated in various experimental models, epidemiological studies, and…”
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Pin1 modulates the type 1 immune response by Esnault, Stephane, Braun, Ruedi K, Shen, Zhong-Jian, Xiang, Zhuzai, Heninger, Erika, Love, Robert B, Sandor, Matyas, Malter, James S

“…BACKGROUND/ABSTRACT: Immune responses initiated by T cell receptor (TCR) and costimulatory molecule mediated signaling culminate in maximal cytokine mRNA…”
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Virally Activated CD8 T Cells Home to Mycobacterium bovis BCG-Induced Granulomas but Enhance Antimycobacterial Protection Only in Immunodeficient Mice by Hogan, Laura H, Co, Dominic O, Karman, Jozsef, Heninger, Erika, Suresh, M, Sandor, Matyas

“…The effect of secondary infections on CD4 T-cell-regulated chronic granulomatous inflammation is not well understood. Here, we have investigated the effect of…”
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Requirements for CD4+ T cell levels in acute Mycobacterium bovis strain bacille Calmette Guérin (BCG)-induced granulomas differ for optimal mycobacterial control versus granuloma formation by Hogan, Laura H., Heninger, Erika, Elsner, Rebecca A., Vonderheid, Heidi A., Hulseberg, Paul, Co, Dominic, Sandor, Matyas

“…Bacille Calmette Guérin (BCG)-induced granulomas contain T cells that express a broad TCR repertoire even at the level of the individual lesion. We have…”
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Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells by Singh, Ashok, Singh, Anupama, Sand, Jordan M., Heninger, Erika, Hafeez, Bilal Bin, Verma, Ajit K.

“…To find clues about the mechanism by which kinase C epsilon (PKCε) may impart susceptibility to ultraviolet radiation (UVR)-induced development of cutaneous…”
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Seasonal changes of proapoptotic soluble Fas ligand level in allergic rhinitis combined with asthma by Mezei, Györgyi, Lévay, Magdolna, Sepler, Zsuzsanna, Héninger, Erika, Kozma, Gergely Tibor, Cserháti, Endre

“…The function of apoptosis is to eliminate unnecessary or dangerous cells. The balance between production and death is important in the control of cell numbers…”
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Abstract 1078: An immunosuppressive signature in bone marrow as a potential biomarker for recurrence of metastatic prostate cancer after prostatectomy by Sethakorn, Nan, Heninger, Erika, Sperger, Jamie M., Pienta, Kenneth J., Lang, Joshua M.

“…Abstract Background: Metastatic prostate cancer is the second leading cause of cancer-related deaths in US men. Nearly one-third of men develop recurrence…”
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Integrated analysis of the tumor microenvironment using a reconfigurable microfluidic cell culture platform by Sethakorn, Nan, Heninger, Erika, Breneman, Matthew T., Recchia, Emma, Ding, Adeline B., Jarrard, David F., Hematti, Peiman, Beebe, David J., Kosoff, David

“…The tumor microenvironment (TME) is a complex network of non‐malignant cells and stroma that perform a wide array of vital roles in tumor growth, immune…”
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Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer by Sperger, Jamie M, Helzer, Kyle T, Stahlfeld, Charlotte N, Jiang, Dawei, Singh, Anupama, Kaufmann, Katherine R, Niles, David J, Heninger, Erika, Rydzewski, Nicholas R, Wang, Liguo, Wang, Liewei, Yang, Rendong, Ren, Yanan, Engle, Jonathan W, Huang, Peng, Kyriakopoulos, Christos E, Slovin, Susan F, Soule, Howard R, Zhao, Shuang G, Kohli, Manish, Tagawa, Scott T, Cai, Weibo, Dehm, Scott M, Lang, Joshua M

“…Men with metastatic castration-resistant prostate cancer (mCRPC) frequently develop resistance to androgen receptor signaling inhibitor (ARSI) treatment;…”
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Abstract B24: A multicellular, microfluidic model of the human bone marrow niche in metastatic cancers by Sethakorn, Nan, Kosoff, David, Heninger, Erika, Soto, Jasmine Martinez, Yu, Jiaquan, Das, Rahul, Jarrard, David, Galipeau, Jacques, Hematti, Peiman, Dehm, Scott, Beebe, David J., Lang, Joshua M.

“…Abstract Bone metastases cause significant morbidity in solid tumors, with prostate, breast, lung, and kidney cancers representing the most common primary…”
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Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice by Nanjappa, Som G, Heninger, Erika, Wüthrich, Marcel, Sullivan, Thomas, Klein, Bruce

“…Individuals who are immunocompromised, including AIDS patients with few CD4(+) T cells, are at increased risk for opportunistic fungal infections. The…”
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