Search Results - "Hengstermann, Arnd"

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers by Mathis, Carole, Poussin, Carine, Weisensee, Dirk, Gebel, Stephan, Hengstermann, Arnd, Sewer, Alain, Belcastro, Vincenzo, Xiang, Yang, Ansari, Sam, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C

“…Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms,…”
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Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival by Hengstermann, Arnd, Müller, Thomas

“…Cigarette smoke (CS) generally places severe stress on cells, as reflected by gene expression profiling and pathway analysis, which, among other effects, also…”
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siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells by BUTZ, Karin, RISTRIANI, Tutik, HENGSTERMANN, Arnd, DENK, Claudia, SCHEFFNER, Martin, HOPPE-SEYLER, Felix

“…The targeted inhibition of antiapoptotic factors in tumour cells may provide a rational approach towards the development of novel anticancer therapies. Using…”
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HdmX Stimulates Hdm2-Mediated Ubiquitination and Degradation of p53 by Linares, Laëtitia K., Hengstermann, Arnd, Ciechanover, Aaron, Müller, Stefan, Scheffner, Martin

“…The RING finger proteins HdmX and Hdm2 share significant structural and functional similarity. Hdm2 is a member of the RING finger family of ubiquitin-protein…”
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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 by Gostissa, Monica, Hengstermann, Arnd, Fogal, Valentina, Sandy, Peter, Schwarz, Sylvia E., Scheffner, Martin, Del Sal, Giannino

“…The growth‐suppressive properties of p53 are controlled by posttranslational modifications and by regulation of its turnover rate. Here we show that p53 can be…”
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Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells by Rothmann, T, Hengstermann, A, Whitaker, N J, Scheffner, M, zur Hausen, H

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Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence by Gebel, Stephan, Lichtner, Rosemarie B., Frushour, Brian, Schlage, Walter K., Hoang, Vy, Talikka, Marja, Hengstermann, Arnd, Mathis, Carole, Veljkovic, Emilija, Peck, Michael, Peitsch, Manuel C., Deehan, Renee, Hoeng, Julia, Westra, Jurjen W.

“…Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology…”
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Involvement of the DNA Repair Protein hHR23 in p53 Degradation by Glockzin, Sandra, Ogi, Francois-Xavier, Hengstermann, Arnd, Scheffner, Martin, Blattner, Christine

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Complete Switch from Mdm2 to Human Papillomavirus E6-Mediated Degradation of p53 in Cervical Cancer Cells by Hengstermann, Arnd, Linares, Laetitia K., Ciechanover, Aaron, Whitaker, Noel J., Scheffner, Martin

“…The E6 oncoprotein of human papillomaviruses (HPVs) that are associated with cervical cancer utilizes the cellular ubiquitin-protein ligase E6-AP to target the…”
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A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue by Westra, Jurjen W., Schlage, Walter K., Hengstermann, Arnd, Gebel, Stephan, Mathis, Carole, Thomson, Ty, Wong, Ben, Hoang, Vy, Veljkovic, Emilija, Peck, Michael, Lichtner, Rosemarie B., Weisensee, Dirk, Talikka, Marja, Deehan, Renee, Hoeng, Julia, Peitsch, Manuel C.

“…Exposure to environmental stressors such as cigarette smoke (CS) elicits a variety of biological responses in humans, including the induction of inflammatory…”
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Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53 by HENGSTERMANN, Arnd, D'SILVA, Michael A, KUBALLA, Petric, BUTZ, Karin, HOPPE-SEYLER, Felix, SCHEFFNER, Martin

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A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro by Mathis, Carole, Gebel, Stephan, Poussin, Carine, Belcastro, Vincenzo, Sewer, Alain, Weisensee, Dirk, Hengstermann, Arnd, Ansari, Sam, Wagner, Sandra, Peitsch, Manuel C., Hoeng, Julia

“…To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed…”
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Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation by HENGSTERMANN, A, WHITAKER, N. J, ZIMMER, D, ZENTGRAF, H, SCHEFFNER, M

“…The growth suppressive properties of the tumor suppressor protein p53 are activated upon DNA damage. The activation of p53 is reflected in increased p53 levels…”
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Nrf2: Friend and Foe in Preventing Cigarette Smoking-Dependent Lung Disease by Müller, Thomas, Hengstermann, Arnd

“…Chronic exposure to cigarette smoke (CS) generally confronts cellular defense systems with one of the strongest known environmental challenges. In particular,…”
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Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells by Hengstermann, Arnd, Linares, Laetitia K., Ciechanover, Aaron, Whitaker, Noel J., Scheffner, Martin

“…The E6 oncoprotein of human papillomaviruses (HPVs) that are associated with cervical cancer utilizes the cellular ubiquitin–protein ligase E6-AP to target the…”
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A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue by Schlage, Walter K, Westra, Jurjen W, Gebel, Stephan, Catlett, Natalie L, Mathis, Carole, Frushour, Brian P, Hengstermann, Arnd, Van Hooser, Aaron, Poussin, Carine, Wong, Ben, Lietz, Michael, Park, Jennifer, Drubin, David, Veljkovic, Emilija, Peitsch, Manuel C, Hoeng, Julia, Deehan, Renee

“…Humans and other organisms are equipped with a set of responses that can prevent damage from exposure to a multitude of endogenous and environmental stressors…”
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Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression by Sewer, Alain, Gubian, Sylvain, Kogel, Ulrike, Veljkovic, Emilija, Han, Wanjiang, Hengstermann, Arnd, Peitsch, Manuel C, Hoeng, Julia

“…High-quality expression data are required to investigate the biological effects of microRNAs (miRNAs). The goal of this study was, first, to assess the quality…”
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Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
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Systems biology approach reveals a dose-dependent recovery of primary human airway epithelium culture after exposure to cigarette smoke by Mathis, Carole, Gebel, Stephan, Poussin, Carine, Hengstermann, Arnd, Weisensee, Dirk, Sewer, Alain, Belcastro, Vincenzo, Ansari, Sam, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C.

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Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke by Knörr-Wittmann, Constanze, Hengstermann, Arnd, Gebel, Stephan, Alam, Jawed, Müller, Thomas

“…Cigarette smoke (CS) is a complex chemical mixture estimated to be composed of up to 5000 different chemicals, many of which are prooxidant. Here we show that,…”
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