Search Results - "Hengel, Shawna Mae"

Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates by Sanderson, Russell J, Nicholas, Nicole D, Baker Lee, Cassandra, Hengel, Shawna Mae, Lyon, Robert P, Benjamin, Dennis R, Alley, Stephen C

“…Antibody-drug conjugates (ADCs) require multiple assays to characterize their PK. These assays can separately evaluate the ADC by quantifying the antibody or…”
Get full text

Measurement of in Vivo Drug Load Distribution of Cysteine-Linked Antibody–Drug Conjugates Using Microscale Liquid Chromatography Mass Spectrometry by Hengel, Shawna Mae, Sanderson, Russell, Valliere-Douglass, John, Nicholas, Nicole, Leiske, Chris, Alley, Stephen C

“…Analysis of samples containing intact antibody–drug conjugates (ADC) using mass spectrometry provides a direct measurement of the drug-load distribution. Once…”
Get full text

Data-independent Proteomic Screen Identifies Novel Tamoxifen Agonist that Mediates Drug Resistance by Hengel, Shawna Mae, Murray, Euan, Langdon, Simon, Hayward, Larry, O’Donoghue, Jean, Panchaud, Alexandre, Hupp, Ted, Goodlett, David R

“…A label-free quantitative variation of the recently developed data-independent shotgun proteomic method precursor acquisition independent from ion count…”
Get full text

Abstract 5551: SGN-2FF: A small-molecule inhibitor of fucosylation modulates immune cell activity in preclinical models and demonstrates pharmacodynamic activity in early phase 1 analysis by Okeley, Nicole M., Heiser, Ryan A., Zeng, Weiping, Hengel, Shawna Mae, Wall, Jason, Haughney, Peter C., Yap, Timothy Anthony, Robert, Francisco, Sanborn, Rachel E., Burris, Howard, Chow, Laura Q., Do, Khanh T., Gutierrez, Martin, Reckamp, Karen, Weise, Amy, Camidge, D Ross, Strickler, John, Steuer, Conor, Wang, Zejing, O'Meara, Megan M., Alley, Stephen C., Gardai, Shyra J.

“…SGN-2FF, an orally bioavailable small molecule inhibitor of glycoprotein fucosylation, demonstrates encouraging preclinical antitumor activity in mouse models…”
Get full text

Proteomic mass spectrometry: From data-independent proteome profiling to the characterization of post -translational modifications by Hengel, Shawna Mae

“…As instrumentation and mass spectrometry methods have advanced over the last century, the analyses of proteins and biological molecules of interest have…”
Get full text

Proteomic mass spectrometry: From data-independent proteome profiling to the characterization of post-translational modifications by Hengel, Shawna Mae

“…As instrumentation and mass spectrometry methods have advanced over the last century, the analyses of proteins and biological molecules of interest have…”
Get full text