Search Results - "Heng, Julian Ik‐Tsen"

Mutations in the β-Tubulin Gene TUBB5 Cause Microcephaly with Structural Brain Abnormalities by Breuss, Martin, Heng, Julian Ik-Tsen, Poirier, Karine, Tian, Guoling, Jaglin, Xavier Hubert, Qu, Zhengdong, Braun, Andreas, Gstrein, Thomas, Ngo, Linh, Haas, Matilda, Bahi-Buisson, Nadia, Moutard, Marie-Laure, Passemard, Sandrine, Verloes, Alain, Gressens, Pierre, Xie, Yunli, Robson, Kathryn J.H., Rani, Deepa Selvi, Thangaraj, Kumarasamy, Clausen, Tim, Chelly, Jamel, Cowan, Nicholas Justin, Keays, David Anthony

“…The formation of the mammalian cortex requires the generation, migration, and differentiation of neurons. The vital role that the microtubule cytoskeleton…”
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RP58 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Cerebral Cortex by Ohtaka-Maruyama, Chiaki, Hirai, Shinobu, Miwa, Akiko, Heng, Julian Ik-Tsen, Shitara, Hiroshi, Ishii, Rie, Taya, Choji, Kawano, Hitoshi, Kasai, Masataka, Nakajima, Kazunori, Okado, Haruo

“…Accumulating evidence suggests that many brain diseases are associated with defects in neuronal migration, suggesting that this step of neurogenesis is…”
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Reinforcing the association between distal 1q CNVs and structural brain disorder: A case of a complex 1q43-q44 CNV and a review of the literature by Hemming, Isabel A., Forrest, Alistair R. R., Shipman, Peter, Woodward, Karen J., Walsh, Peter, Ravine, David G., Heng, Julian Ik-Tsen

“…Copy Number Variations (CNVs) comprising the distal 1q region 1q43‐q44 are associated with neurological impairments, structural brain disorder, and…”
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A review of structural brain abnormalities in Pallister‐Killian syndrome by Poulton, Cathryn, Baynam, Gareth, Yates, Clarissa, Alinejad‐Rokny, Hamid, Williams, Simon, Wright, Helen, Woodward, Karen J., Sivamoorthy, Soruba, Peverall, Joanne, Shipman, Peter, Ravine, David, Beilby, John, Heng, Julian Ik‐Tsen

“…Background Pallister‐Killian syndrome (PKS) is a rare multisystem developmental syndrome usually caused by mosaic tetrasomy of chromosome 12p that is known to…”
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Further evidence for distinct traits associated with RBM10 missense variants by Poulton, Cathryn, Baynam, Gareth, Pugh, Kye, Mason, Michael, Kiraly‐Borri, Catherine, Gration, Dylan, Dreyer, Lauren, Viti, Leon, Agostino, Mark, Heng, Julian Ik‐Tsen

“…A case of a missense RBM10 variant in an adult with mild to moderate intellectual disability…”
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Neurogenin 2 controls cortical neuron migration through regulation of Rnd2 by Nguyen, Laurent, Hevner, Robert, Matter, Jean-Marc, Wildner, Hendrik, Heng, Julian Ik-Tsen, Guillemot, François, Zimmer, Céline, Bedogni, Francesco, Castro, Diogo S, Armant, Olivier, Skowronska-Krawczyk, Dorota

“…Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well…”
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The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development by Heng, Julian Ik-Tsen, Qu, Zhengdong, Ohtaka-Maruyama, Chiaki, Okado, Haruo, Kasai, Masataka, Castro, Diogo, Guillemot, François, Tan, Seong-Seng

“…The zinc finger transcription factor RP58 (also known as ZNF238) regulates neurogenesis of the mouse neocortex and cerebellum (Okado et al. 2009; Xiang et al…”
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Editorial: Transcription and chromatin regulators in neurodevelopmental disorders by van den Berg, Debbie L. C., Heng, Julian Ik-Tsen, Sessa, Alessandro, Dias, Cristina

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Phosphorylation of Neurogenin2 Specifies the Migration Properties and the Dendritic Morphology of Pyramidal Neurons in the Neocortex by Hand, Randal, Bortone, Dante, Mattar, Pierre, Nguyen, Laurent, Heng, Julian Ik-Tsen, Guerrier, Sabrice, Boutt, Elizabeth, Peters, Eldon, Barnes, Anthony P., Parras, Carlos, Schuurmans, Carol, Guillemot, François, Polleux, Franck

“…The molecular mechanisms specifying the dendritic morphology of different neuronal subtypes are poorly understood. Here we demonstrate that the bHLH…”
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COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression by Alfano, Christian, Viola, Luigi, Heng, Julian Ik-Tsen, Pirozzi, Marinella, Clarkson, Michael, Flore, Gemma, De Maio, Antonia, Schedl, Andreas, Guillemot, François, Studer, Michèle

“…During corticogenesis, late-born callosal projection neurons (CPNs) acquire their laminar position through glia-guided radial migration and then undergo final…”
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Insights into the Biology and Therapeutic Applications of Neural Stem Cells by Heng, Julian Ik-Tsen, Piper, Michael, Zalucki, Oressia, Harris, Lachlan

“…The cerebral cortex is essential for our higher cognitive functions and emotional reasoning. Arguably, this brain structure is the distinguishing feature of…”
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Coupling of Cell Migration with Neurogenesis by Proneural bHLH Factors by Ge, Weihong, He, Fei, Kim, Kevin J., Blanchi, Bruno, Coskun, Volkan, Nguyen, Laurent, Wu, Xiangbing, Zhao, Jing, Heng, Julian Ik-Tsen, Martinowich, Keri, Tao, Jifang, Wu, Hao, Castro, Diogo, Sobeih, Magdi M., Corfas, Gabriel, Gleeson, Joseph G., Greenberg, Michael E., Guillemot, Francois, Sun, Yi E.

“…After cell birth, almost all neurons in the mammalian central nervous system migrate. It is unclear whether and how cell migration is coupled with…”
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Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons by Gladwyn-Ng, Ivan, Huang, Lieven, Ngo, Linh, Li, Shan Shan, Qu, Zhengdong, Vanyai, Hannah Kate, Cullen, Hayley Daniella, Davis, John Michael, Heng, Julian Ik-Tsen

“…The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic…”
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Molecular mechanisms of projection neuron production and maturation in the developing cerebral cortex by Mérot, Yohann, Rétaux, Sylvie, Heng, Julian Ik-Tsen

“…The cerebral cortex is a brain structure unique to mammals and highly adapted to process complex information. Through multiple developmental steps, the…”
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The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein by Lasorella, Anna, Jiang, Richeng, Zhao, Xudong, Heng, Julian Ik-Tsen, Pagano, Michele, Guillemot, Francois, Iavarone, Antonio, Guardavaccaro, Daniele

“…Development of the nervous system requires that timely withdrawal from the cell cycle be coupled with initiation of differentiation. Ubiquitin-mediated…”
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Molecular layers underlying cytoskeletal remodelling during cortical development by Heng, Julian Ik-Tsen, Chariot, Alain, Nguyen, Laurent

“…During neural development, the cytoskeleton of newborn neurons undergoes extensive and dynamic remodelling to facilitate the sequential steps of neurogenesis,…”
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Structure-Based Approaches to Classify the Functional Impact of ZBTB18 Missense Variants in Health and Disease by Blake, Steven, Hemming, Isabel, Heng, Julian Ik-Tsen, Agostino, Mark

“…The Cys2His2 type zinc finger is a motif found in many eukaryotic transcription factor proteins that facilitates binding to genomic DNA so as to influence…”
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Quantitative neurogenetics: applications in understanding disease by Afrasiabi, Ali, Keane, Jeremy T, Heng, Julian Ik-Tsen, Palmer, Elizabeth E, Lovell, Nigel H, Alinejad-Rokny, Hamid

“…Neurodevelopmental and neurodegenerative disorders (NNDs) are a group of conditions with a broad range of core and co-morbidities, associated with dysfunction…”
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Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway by Edvardson, Shimon, Tian, Guoling, Cullen, Hayley, Vanyai, Hannah, Ngo, Linh, Bhat, Saiuj, Aran, Adi, Daana, Muhannad, Da'amseh, Naderah, Abu-Libdeh, Bassam, Cowan, Nicholas J, Heng, Julian Ik-Tsen, Elpeleg, Orly

“…Mutation in a growing spectrum of genes is known to either cause or contribute to primary or secondary microcephaly. In primary microcephaly the genetic…”
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REVIEW ARTICLE: Neurotransmitters regulate cell migration in the telencephalon by Heng, Julian Ik-Tsen, Moonen, Gustave, Nguyen, Laurent

“…The complex cytoarchitectonic organization of the adult mammalian telencephalon reflects the elaborate patterns of cell migration that contribute to its…”
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