Search Results - "Heng, Henry H."

The Spiral Model of Evolution: Stable Life Forms of Organisms and Unstable Life Forms of Cancers by Kasperski, Andrzej, Heng, Henry H

“…If one must prioritize among the vast array of contributing factors to cancer evolution, environmental-stress-mediated chromosome instability (CIN) should…”
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Transient and stable vector transfection: Pitfalls, off-target effects, artifacts by Stepanenko, Aleksei A., Heng, Henry H.

“…[Display omitted] Transient and stable vector transfections have played important roles in illustrating the function of specific genes/proteins. The general…”
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Karyotype coding: The creation and maintenance of system information for complexity and biodiversity by Heng, Julie, Heng, Henry H.

“…The mechanism of biological information flow is of vital importance. However, traditional research surrounding the genetic code that follows the central dogma…”
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Further illusions: On key evolutionary mechanisms that could never fit with Modern Synthesis by Crkvenjakov, Radomir, Heng, Henry H.

“…In light of illusions of the Modern Synthesis (MS) listed by Noble (2021a), MS's key concept, that gradual accumulation of gene mutations within microevolution…”
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Editorial: Somatic genomic mosaicism & human disease by Iourov, Ivan Y., Heng, Henry H.

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Origins and Consequences of Chromosomal Instability: From Cellular Adaptation to Genome Chaos-Mediated System Survival by Ye, Christine J, Sharpe, Zachary, Heng, Henry H

“…When discussing chromosomal instability, most of the literature focuses on the characterization of individual molecular mechanisms. These studies search for…”
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What Is Karyotype Coding and Why Is Genomic Topology Important for Cancer and Evolution? by Ye, Christine J., Stilgenbauer, Lukas, Moy, Amanda, Liu, Guo, Heng, Henry H.

“…While the importance of chromosomal/nuclear variations vs. gene mutations in diseases is becoming more appreciated, less is known about its genomic basis…”
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The Conflict Between Complex Systems and Reductionism by Heng, Henry H. Q

“…Heng analyzes the conflict between reductionism and complex systems. With increasing technological capabilities, these systems can be examined in continuously…”
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Distinguishing constitutional and acquired nonclonal aneuploidy by Heng, Henry H

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Somatic Genomic Mosaicism in Multiple Myeloma by Ye, Christine J, Chen, Jason, Liu, Guo, Heng, Henry H

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Evolutionary mechanism unifies the hallmarks of cancer by Horne, Steven D., Pollick, Sarah A., Heng, Henry H.Q.

“…The basis for the gene mutation theory of cancer that dominates current molecular cancer research consists of: the belief that gene‐level aberrations such as…”
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Stress, genomic adaptation, and the evolutionary trade-off by Horne, Steven D, Chowdhury, Saroj K, Heng, Henry H Q

“…Cells are constantly exposed to various internal and external stresses. The importance of cellular stress and its implication to disease conditions have become…”
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Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems by Ye, Christine J, Regan, Sarah, Liu, Guo, Alemara, Sarah, Heng, Henry H

“…In the past 15 years, impressive progress has been made to understand the molecular mechanism behind aneuploidy, largely due to the effort of using various…”
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Missing heritability and stochastic genome alterations by Heng, Henry H. Q

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Genome chaos: Creating new genomic information essential for cancer macroevolution by Heng, Julie, Heng, Henry H.

“…Cancer research has traditionally focused on the characterization of individual molecular mechanisms that can contribute to cancer. Due to the multiple levels…”
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Therapy Induced Genome Chaos: A Novel Mechanism of Rapid Cancer Drug Resistance by Ye, Jing Christine, Horne, Steve, Zhang, Jack Z, Jackson, Lauren, Heng, Henry H

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genome-centric concept: resynthesis of evolutionary theory by Heng, Henry H.Q

“…Modern biology has been heavily influenced by the gene-centric concept. Paradoxically, this very concept - on which bioresearch is based - is challenged by the…”
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ER Stress and Micronuclei Cluster: Stress Response Contributes to Genome Chaos in Cancer by Heng, Eric, Moy, Amanda, Liu, Guo, Heng, Henry H, Zhang, Kezhong

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Why it is crucial to analyze non clonal chromosome aberrations or NCCAs? by Heng, Henry H Q, Regan, Sarah M, Liu, Guo, Ye, Christine J

“…Current cytogenetics has largely focused its efforts on the identification of recurrent karyotypic alterations, also known as clonal chromosomal aberrations…”
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Health and Disease-Emergent States Resulting From Adaptive Social and Biological Network Interactions by Sturmberg, Joachim P, Picard, Martin, Aron, David C, Bennett, Jeanette M, Bircher, Johannes, deHaven, Mark J, Gijzel, Sanne M W, Heng, Henry H, Marcum, James A, Martin, Carmel M, Miles, Andrew, Peterson, Chris L, Rohleder, Nicolas, Walker, Christine, Olde Rikkert, Marcel G M, Melis, René J F

“…Health is an adaptive state unique to each person. This subjective state must be distinguished from the objective state of disease. The experience of health…”
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