Search Results - "Heng, Chew Kiat"

Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies by Dorajoo, Rajkumar, Chang, Xuling, Gurung, Resham Lal, Li, Zheng, Wang, Ling, Wang, Renwei, Beckman, Kenneth B., Adams-Haduch, Jennifer, M, Yiamunaa, Liu, Sylvia, Meah, Wee Yang, Sim, Kar Seng, Lim, Su Chi, Friedlander, Yechiel, Liu, Jianjun, van Dam, Rob M., Yuan, Jian-Min, Koh, Woon-Puay, Khor, Chiea Chuen, Heng, Chew-Kiat

“…Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic…”
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Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases by Kee, Zizheng, Ong, Sze Min, Heng, Chew-Kiat, Ooi, Delicia Shu Qin

“…The first genome-wide association study on coronary artery disease (CAD) in the Han Chinese population identified C6orf105 as a susceptibility gene. The…”
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Interaction between cigarette smoking and genetic polymorphisms on the associations with age of natural menopause and reproductive lifespan: the Singapore Chinese Health Study by Huang, Zhongwei, Chang, Xuling, Wang, Ling, Liu, Jianjun, Heng, Chew-Kiat, Khor, Chiea-Chuen, Yuan, Jian-Min, Koh, Woon-Puay, Dorajoo, Rajkumar

“…Abstract STUDY QUESTION Are there genetic variants that interact with smoking to reduce reproductive lifespan in East-Asian women? SUMMARY ANSWER Our study…”
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Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease by Ooi, Delicia Shu Qin, Ong, Sze Min, Eng, Ming Hui, Chan, Yiong Huak, Lee, Yung Seng, Low, Adrian Fatt Hoe, Chan, Mark Yan-Yee, Heng, Chew-Kiat

“…Androgen dependent tissue factor pathway inhibitor regulating protein (ADTRP) is a novel protein associated with coronary artery disease (CAD) susceptibility,…”
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Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population by Chang, Xuling, Dorajoo, Rajkumar, Sun, Ye, Wang, Ling, Ong, Choon Nam, Liu, Jianjun, Khor, Chiea Chuen, Yuan, Jian-Min, Koh, Woon Puay, Friedlander, Yechiel, Heng, Chew-Kiat

“…Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. Excessive shortening of…”
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Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures by Chee Furng Wong, Danny, Tin Kam Wong, Kathy, Tang Goh, Lin, Kiat Heng, Chew, Gek Sim Yap, Miranda

“…As we pursue the means to improve yields to meet growing therapy demands, it is important to examine the impact of process control on glycosylation patterns to…”
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A novel model for predicting non‐responsiveness to intravenous immunoglobulins in Kawasaki disease: The Singapore experience by Grignani, Robert, Rajgor, Dimple D, Leow, Yao‐Guang, Heng, Chew‐Kiat, Quek, Swee‐Chye

“…Aim We aimed to assess the utility of four published risk‐scoring methods in predicting intravenous immunoglobulins (IVIG) non‐responsiveness in Kawasaki…”
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Differences in AMY1 Gene Copy Numbers Derived from Blood, Buccal Cells and Saliva Using Quantitative and Droplet Digital PCR Methods: Flagging the Pitfall by Ooi, Delicia Shu Qin, Tan, Verena Ming Hui, Ong, Siong Gim, Chan, Yiong Huak, Heng, Chew Kiat, Lee, Yung Seng

“…The human salivary (AMY1) gene, encoding salivary α-amylase, has variable copy number variants (CNVs) in the human genome. We aimed to determine if real-time…”
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NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population by Thomas, Claire E., Diergaarde, Brenda, Kuipers, Allison L., Adibi, Jennifer J., Luu, Hung N., Chang, Xuling, Dorajoo, Rajkumar, Heng, Chew‐Kiat, Khor, Chiea‐Chuen, Wang, Renwei, Jin, Aizhen, Koh, Woon‐Puay, Yuan, Jian‐Min

“…It is difficult to identify people with nonalcoholic fatty liver disease (NAFLD) who are at high risk for developing hepatocellular carcinoma (HCC). A…”
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Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia by Han, Yi, Dorajoo, Rajkumar, Chang, Xuling, Wang, Ling, Khor, Chiea-Chuen, Sim, Xueling, Cheng, Ching-Yu, Shi, Yuan, Tham, Yih Chung, Zhao, Wanting, Chee, Miao Ling, Sabanayagam, Charumathi, Chee, Miao Li, Tan, Nicholas, Wong, Tien Yin, Tai, E-Shyong, Liu, Jianjun, Goh, Daniel Y. T., Yuan, Jian-Min, Koh, Woon-Puay, van Dam, Rob M., Low, Adrian F., Chan, Mark Yan-Yee, Friedlander, Yechiel, Heng, Chew-Kiat

“…Recent genome-wide association studies (GWAS) have identified multiple loci associated with coronary artery disease (CAD) among predominantly Europeans…”
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genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population by Dorajoo, Rajkumar, Sun, Ye, Han, Yi, Ke, Tingjing, Burger, Ayala, Chang, Xuling, Low, Hui Qi, Guan, Weihua, Lemaitre, Rozenn N, Khor, Chiea-Chuen, Yuan, Jian-Min, Koh, Woon-Puay, Ong, Choon Nam, Tai, E Shyong, Liu, Jianjun, van Dam, Rob M, Heng, Chew-Kiat, Friedlander, Yechiel

“…Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci…”
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Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population by Chang, Xuling, Gurung, Resham L., Wang, Ling, Jin, Aizhen, Li, Zheng, Wang, Renwei, Beckman, Kenneth B., Adams-Haduch, Jennifer, Meah, Wee Yang, Sim, Kar Seng, Lim, Weng Khong, Davila, Sonia, Tan, Patrick, Teo, Jing Xian, Yeo, Khung Keong, M., Yiamunaa, Liu, Sylvia, Lim, Su Chi, Liu, Jianjun, van Dam, Rob M., Friedlander, Yechiel, Koh, Woon-Puay, Yuan, Jian-Min, Khor, Chiea Chuen, Heng, Chew-Kiat, Dorajoo, Rajkumar

“…The role of low frequency variants associated with telomere length homeostasis in chronic diseases and mortalities is relatively understudied in the East-Asian…”
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Sequential Responses to High-fat and High-calorie Feeding in an Obese Mouse Model by Chan, Mei‐Yen, Zhao, Yulan, Heng, Chew‐Kiat

“…Objective: Reports on the immediate and long‐term responses to high‐fat and high‐calorie (HFC) feeding are controversial. Therefore, we examined the sequential…”
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Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population by Chang, Xuling, Dorajoo, Rajkumar, Han, Yi, Wang, Ling, Liu, Jianjun, Khor, Chiea‐Chuen, Low, Adrian F., Chan, Mark Yan‐Yee, Yuan, Jian‐Min, Koh, Woon‐Puay, Friedlander, Yechiel, Heng, Chew‐Kiat

“…Background Haptoglobin (Hp) is a plasma protein with strong anti‐inflammation and antioxidant activities. Its plasma level is known to be inversely associated…”
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Impact of Serum Amyloid A on Tissue Factor and Tissue Factor Pathway Inhibitor Expression and Activity in Endothelial Cells by Zhao, Yulan, Zhou, Shuli, Heng, Chew-Kiat

“…OBJECTIVE—Although serum amyloid A (SAA) is a useful biomarker of coronary artery disease (CAD), its direct role in procoagulation is obscure. This study…”
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Gene-diet interaction effects on BMI levels in the Singapore Chinese population by Chang, Xuling, Dorajoo, Rajkumar, Sun, Ye, Han, Yi, Wang, Ling, Khor, Chiea-Chuen, Sim, Xueling, Tai, E-Shyong, Liu, Jianjun, Yuan, Jian-Min, Koh, Woon-Puay, van Dam, Rob M, Friedlander, Yechiel, Heng, Chew-Kiat

“…Recent genome-wide association studies (GWAS) have identified 97 body-mass index (BMI) associated loci. We aimed to evaluate if dietary intake modifies BMI…”
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MEFV E148Q polymorphism is associated with Henoch–Schönlein purpura in Chinese children by He, Xuelian, Lu, Hao, Kang, Shixiu, Luan, Jiangwei, Liu, Zhisheng, Yin, Wei, Yao, Hui, Ding, Yan, Li, Tao, Heng, Chew-Kiat

“…Henoch–Schönlein purpura (HSP) is a multifactorial inflammatory disease whose pathogenesis remains unknown. Pyrin encoded by the MEFV gene (NM_000243; OMIM…”
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Targeting early apoptotic genes in batch and fed-batch CHO cell cultures by Wong, Danny Chee Furng, Wong, Kathy Tin Kam, Nissom, Peter Morin, Heng, Chew Kiat, Yap, Miranda Gek Sim

“…Based on the transcriptional profiling of CHO cell culture using microarray, four key early apoptosis signaling genes, Fadd, Faim, Alg‐2, and Requiem, were…”
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Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media by Chong, William P.K., Yusufi, Faraaz N.K., Lee, Dong-Yup, Reddy, Satty G., Wong, Niki S.C., Heng, Chew Kiat, Yap, Miranda G.S., Ho, Ying Swan

“…A liquid chromatography–mass spectrometry (LC–MS) based metabolomics platform was previously established to identify and profile extracellular metabolites in…”
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A five-safes approach to a secure and scalable genomics data repository by Shih, Chih Chuan, Chen, Jieqi, Lee, Ai Shan, Bertin, Nicolas, Hebrard, Maxime, Khor, Chiea Chuen, Li, Zheng, Juan Tan, Joanna Hui, Meah, Wee Yang, Peh, Su Qin, Mok, Shi Qi, Sim, Kar Seng, Liu, Jianjun, Wang, Ling, Wong, Eleanor, Li, Jingmei, Tin, Aung, Cheng, Ching-Yu, Heng, Chew-Kiat, Yuan, Jian-Min, Koh, Woon-Puay, Saw, Seang Mei, Friedlander, Yechiel, Sim, Xueling, Chai, Jin Fang, Chong, Yap Seng, Davila, Sonia, Goh, Liuh Ling, Lee, Eng Sing, Wong, Tien Yin, Karnani, Neerja, Leong, Khai Pang, Yeo, Khung Keong, Chambers, John C., Lim, Su Chi, Goh, Rick Siow Mong, Tan, Patrick, Dorajoo, Rajkumar

“…Genomic researchers increasingly utilize commercial cloud service providers (CSPs) to manage data and analytics needs. CSPs allow researchers to grow…”
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