Randomised trial of bisphosphonate-coated dental implants: Radiographic follow-up after five years of loading

Abstract The results of a randomised trial with bisphosphonate-coated dental implants have been reported previously. Each patient received one coated and one uncoated implant in a double-blind split-mouth design study. After 6 months of osseointegration, resonance frequency analysis indicated better...

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Bibliographic Details
Published in:	International journal of oral and maxillofacial surgery Vol. 45; no. 12; pp. 1564 - 1569
Main Authors:	Abtahi, J, Henefalk, G, Aspenberg, P
Format:	Journal Article
Language:	English
Published:	Denmark Elsevier Ltd 01-12-2016
Subjects:	Aged Bone Density Conservation Agents - administration & dosage bone healing Bone Resorption - diagnostic imaging dental implant Dental Implantation, Endosseous Dental Implants Dental Restoration Failure Dentistry Diphosphonates - administration & dosage Double-Blind Method Female Follow-Up Studies Humans Male marginal bone loss Middle Aged Osseointegration radiographic evaluation Surgery Treatment Outcome radiographic evaluation marginal bone loss dental implant bone healing
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Summary:	Abstract The results of a randomised trial with bisphosphonate-coated dental implants have been reported previously. Each patient received one coated and one uncoated implant in a double-blind split-mouth design study. After 6 months of osseointegration, resonance frequency analysis indicated better fixation of the coated implants. Reduced marginal bone resorption was also shown. However, it was not known whether the advantage of the bisphosphonate coating would persist over time. The radiographic results at 5 years after implant installation are reported herein. A blinded investigator measured marginal resorption on fresh radiographs obtained for 14 of the 16 patients (two had died) and compared these with the post-implantation images. Non-parametric statistics were used. All implants functioned well. The median marginal bone loss for control implants was found to be 0.70 mm, which is less than usually reported in the literature. The bisphosphonate-coated implants showed even less resorption (median 0.20 mm). The median difference within each pair of implants after 5 years of use was 0.34 mm (95% confidence interval 0.00–0.75 mm; P = 0.04). The present data suggest that bisphosphonate-coated implants enable prolonged preservation of the marginal bone.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0901-5027 1399-0020 1399-0020
DOI:	10.1016/j.ijom.2016.09.001