Antibody removal and subsequent transplantation of a highly sensitised paediatric renal patient

We report a successful renal transplant in a highly sensitised paediatric recipient following removal of HLA-specific antibodies by extracorporeal immunoadsorption. The immediate pretransplant cytotoxic titre against the donor was greater than 1:512; this was reduced to negativity by two immunoadsor...

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Bibliographic Details
Published in:	Transplant international Vol. 9; no. 2; p. 155
Main Authors:	Bevan, D J, Carey, B S, Lea, C K, Vaughan, R W, Rigden, S P, Higgins, R M, Hendry, B N, Koffman, C G, Bewick, M
Format:	Journal Article
Language:	English
Published:	England 01-03-1996
Subjects:	Autoantibodies Child Graft Rejection - immunology Graft Rejection - therapy HLA Antigens - immunology Humans Immunosorbents Kidney Transplantation - immunology Male Renal Dialysis - methods
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Summary:	We report a successful renal transplant in a highly sensitised paediatric recipient following removal of HLA-specific antibodies by extracorporeal immunoadsorption. The immediate pretransplant cytotoxic titre against the donor was greater than 1:512; this was reduced to negativity by two immunoadsorption sessions prior to transplant surgery. We also describe the presence of unexpected non-HLA-specific antibody activities in this immunoadsorbed patient.
ISSN:	0934-0874
DOI:	10.1111/j.1432-2277.1996.tb00871.x