Search Results - "Hendrix, Hanne"
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PlzR regulates type IV pili assembly in Pseudomonas aeruginosa via PilZ binding
Published in Nature communications (08-10-2024)“…Type IV pili (T4P) are thin, flexible filaments exposed on the cell surface of gram-negative bacteria and are involved in pathogenesis-related processes,…”
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Pseudomonas predators: understanding and exploiting phage–host interactions
Published in Nature reviews. Microbiology (26-06-2017)Get full text
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Phage S144, A New Polyvalent Phage Infecting Salmonella spp. and Cronobacter sakazakii
Published in International journal of molecular sciences (22-07-2020)“…Phages are generally considered species- or even strain-specific, yet polyvalent phages are able to infect bacteria from different genera. Here, we…”
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Bacteriophage‐mediated interference of the c‐di‐GMP signalling pathway in Pseudomonas aeruginosa
Published in Microbial biotechnology (01-05-2021)“…C‐di‐GMP is a key signaling molecule which impacts bacterial motility and biofilm formation and is formed by the condensation of two GTP molecules by a…”
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Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome
Published in eLife (22-07-2016)“…In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is…”
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A SEVA-based, CRISPR-Cas3-assisted genome engineering approach for Pseudomonas with efficient vector curing
Published in Microbiology spectrum (12-12-2023)“…The CRISPR-Cas3 editing system as presented here facilitates the creation of genomic alterations in and in a straightforward manner. By providing the Cas3…”
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Novel N4-Like Bacteriophages of Pectobacterium atrosepticum
Published in Pharmaceuticals (Basel, Switzerland) (14-05-2018)“…is an economically important phytopathogen that is responsible for potato blackleg and soft rot, and for which current control strategies are limited. In this…”
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The phage-encoded protein PIT2 impacts Pseudomonas aeruginosa quorum sensing by direct interaction with LasR
Published in iScience (20-10-2023)“…In recent decades, there has been a notable increase in antibiotic-resistant Pseudomonas aeruginosa isolates, necessitating the development of innovative…”
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The Phage-Encoded N -Acetyltransferase Rac Mediates Inactivation of Pseudomonas aeruginosa Transcription by Cleavage of the RNA Polymerase Alpha Subunit
Published in Viruses (02-09-2020)“…In this study, we describe the biological function of the phage-encoded protein RNA polymerase alpha subunit cleavage protein (Rac), a predicted Gcn5-related…”
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Isolation and Characterization of Pectobacterium Phage vB_PatM_CB7: New Insights into the Genus Certrevirus
Published in Antibiotics (Basel) (01-06-2020)“…To date, Certrevirus is one of two genera of bacteriophage (phage), with phages infecting Pectobacterium atrosepticum, an economically important phytopathogen…”
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11
Pseudomonas predators: understanding and exploiting phage–host interactions
Published in Nature reviews. Microbiology (01-09-2017)“…Key Points Owing to their wide ecological distribution and genomic diversity, Pseudomonas spp. and their phages provide an excellent model to study the effect…”
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Phage-based target discovery and its exploitation towards novel antibacterial molecules
Published in Current opinion in biotechnology (01-04-2021)“…[Display omitted] •Understanding phage hijacking mechanism can facilitate the discovery of novel antibacterials.•Phage genome-driven screening can reveal novel…”
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Targeted Genome Editing of Virulent Pseudomonas Phages Using CRISPR-Cas3
Published in Methods in molecular biology (Clifton, N.J.) (2024)“…The vast number of unknown phage-encoded ORFan genes and limited insights into the genome organization of phages illustrate the need for efficient genome…”
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Posttranslational modifications in bacteria during phage infection
Published in Current opinion in microbiology (01-02-2024)“…During phage infection, both virus and bacteria attempt to gain and/or maintain control over critical bacterial functions, through a plethora of strategies…”
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FLAMS: Find Lysine Acylations and other Modification Sites
Published in Bioinformatics (Oxford, England) (02-01-2024)“…Today, hundreds of post-translational modification (PTM) sites are routinely identified at once, but the comparison of new experimental datasets to already…”
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Screening for Growth-Inhibitory ORFans in Pseudomonas aeruginosa-Infecting Bacteriophages
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…Like all viruses, bacteriophages heavily depend on their host's physiology for reproduction. Therefore, phages have evolved numerous proteins that influence…”
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A Tailspike with Exopolysaccharide Depolymerase Activity from a New Providencia stuartii Phage Makes Multidrug-Resistant Bacteria Susceptible to Serum-Mediated Killing
Published in Applied and environmental microbiology (17-06-2020)“…is emerging as a significant drug-resistant nosocomial pathogen, which encourages the search for alternative therapies. Here, we have isolated phage Stuart, a…”
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Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation
Published in Cell reports (Cambridge) (15-02-2022)“…The Pseudomonas quinolone signal (PQS) is a multifunctional quorum sensing molecule of key importance to P. aeruginosa. Here, we report that the lytic…”
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qDNase assay: A quantitative method for real-time assessment of DNase activity on coated surfaces
Published in Biochemical and biophysical research communications (01-01-2021)“…DNase coatings show great potential to prevent biofilm formation in various applications of the medical implant, food and marine industry. However,…”
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Analyzing Phage-Host Protein-Protein Interactions Using Strep-tag ® II Purifications
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…After injecting their genome into the bacterial host cell, bacteriophages need to convert the host metabolism toward efficient phage production. For this,…”
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