Search Results - "Hendrikx, M."

Counterion-Dependent Mechanisms of DNA Origami Nanostructure Stabilization Revealed by Atomistic Molecular Simulation by Roodhuizen, Job A. L, Hendrikx, Philip J. T. M, Hilbers, Peter A. J, de Greef, Tom F. A, Markvoort, Albert J

“…The DNA origami technique has proven to have tremendous potential for therapeutic and diagnostic applications like drug delivery, but the relatively low…”
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Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment by Lagerweij, Tonny, Dusoswa, Sophie A., Negrean, Adrian, Hendrikx, Esther M. L., de Vries, Helga E., Kole, Jeroen, Garcia-Vallejo, Juan J., Mansvelder, Huibert D., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Musters, René J. P., van Kooyk, Yvette, Wesseling, Pieter, Zhao, Xi Wen, Wurdinger, Thomas

“…Background Three-dimensional visualization of the brain vasculature and its interactions with surrounding cells may shed light on diseases where aberrant…”
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Haematotoxicity during peptide receptor radionuclide therapy: Baseline parameters differences and effect on patient's therapy course by de Vries-Huizing, Daphne M V, Versleijen, Michelle W J, Sinaasappel, Michiel, Walraven, Iris, Geluk-Jonker, Martine M, Tesselaar, Margot E T, Hendrikx, Jeroen J M A, de Wit-van der Veen, Berlinda J, Stokkel, Marcel P M

“…Mainly severe (CTCAE grade 3-4) haematotoxicity during peptide receptor radionuclide therapy (PRRT) is reported in literature due to major clinical impact,…”
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Tolerability of concurrent external beam radiotherapy and [ 177 Lu]Lu-PSMA-617 for node-positive prostate cancer in treatment naïve patients, phase I study (PROQURE-I trial) by van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, Vogel, Wouter V

“…Prostate cancer patients with locoregional lymph node disease at diagnosis (N1M0) still have a limited prognosis despite the improvements provided by…”
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Validation and implementation of surgical simulators: a critical review of present, past, and future by Schout, B. M. A., Hendrikx, A. J. M., Scheele, F., Bemelmans, B. L. H., Scherpbier, A. J. J. A.

“…Background In the past 20 years the surgical simulator market has seen substantial growth. Simulators are useful for teaching surgical skills effectively and…”
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The effect of distractions in the operating room during endourological procedures by Persoon, Marjolein C., Broos, Hans J. H. P., Witjes, J. Alfred, Hendrikx, Ad. J. M., Scherpbier, Albert J. J. M.

“…Background Professionals working in the operating room (OR) are subject to various distractions that can be detrimental to their task performance and the…”
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Predicting the effect of different folate doses on [68Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling by Siebinga, Hinke, Hendrikx, Jeroen J. M. A., Huitema, Alwin D. R., de Wit-van der Veen, Berlinda J.

“…Background Folate intake might reduce [ 68 Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this…”
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Three-dimensional histochemistry and imaging of human gingiva by Azaripour, Adriano, Lagerweij, Tonny, Scharfbillig, Christina, Jadczak, Anna Elisabeth, Swaan, Britt van der, Molenaar, Manon, Waal, Rens van der, Kielbassa, Karoline, Tigchelaar, Wikky, Picavet, Daisy I., Jonker, Ard, Hendrikx, Esther M. L., Hira, Vashendriya V. V., Khurshed, Mohammed, Noorden, Cornelis J. F. Van

“…In the present study, 3D histochemistry and imaging methodology is described for human gingiva to analyze its vascular network. Fifteen human gingiva samples…”
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Validation of an automated dispensing system for subsequent dose dispensing of different radionuclides by Cao, T. T., Aalbersberg, E. A., Geluk-Jonker, M. M., Hendrikx, J. J. M. A.

“…Background Automated dispensing systems (ADSs) for radiopharmaceuticals have been developed to reduce the radiation exposure of personnel, to improve the…”
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Automated radiolabelling of [68Ga]Ga-PSMA-11 (gallium (68Ga)-gozetotide) using the Locametz® kit and two generators by van Brandwijk, Elke A., Aalbersberg, Else A., Hosseini, Arman S., Huitema, Alwin D. R., Hendrikx, Jeroen J. M. A.

“…Background Steps have been taken by pharmaceutical companies to obtain marketing authorisation of PSMA ligands in the European Union. Since December 2022,…”
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Somatostatin receptor saturation after administration of high peptide amounts of [177Lu]Lu-HA-DOTATATE: when enough is enough by Siebinga, Hinke, Veerman, Chayenne H. A. M., de Wit-van der Veen, Linda, Stokkel, Marcel P. M., Hendrikx, Jeroen J. M. A., Aalbersberg, Else A.

“…Background Receptor saturation during peptide receptor radionuclide therapy (PRRT) could result in altered [ 177 Lu]Lu-HA-DOTATATE uptake in tumors and organs…”
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Alternative dosing strategies for immune checkpoint inhibitors to improve cost-effectiveness: a special focus on nivolumab and pembrolizumab by Malmberg, Ruben, Zietse, Michiel, Dumoulin, Daphne W, Hendrikx, Jeroen J M A, Aerts, Joachim G J V, van der Veldt, Astrid A M, Koch, Birgit C P, Sleijfer, Stefan, van Leeuwen, Roelof W F

“…Immune checkpoint inhibitors have revolutionised cancer treatment by offering durable responses to many patients with solid and haematological cancers. The…”
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A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients by Siebinga, Hinke, de Wit-van der Veen, Berlinda J., Beijnen, Jos H., Dorlo, Thomas P. C., Huitema, Alwin D. R., Hendrikx, Jeroen J. M. A.

“…Background Little is known about parameters that have a relevant impact on (dis)similarities in biodistribution between various 68 Ga-labeled somatostatin…”
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Lipoic Acid Affects Cellular Migration into the Central Nervous System and Stabilizes Blood-Brain Barrier Integrity by Schreibelt, Gerty, Musters, Rene J. P, Reijerkerk, Arie, de Groot, Lody R, van der Pol, Susanne M. A, Hendrikx, Esther M. L, Dopp, Ed D, Dijkstra, Christine D, Drukarch, Benjamin, de Vries, Helga E

“…Reactive oxygen species (ROS) play an important role in various events underlying multiple sclerosis (MS) pathology. In the initial phase of lesion formation,…”
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Muscarinic inhibition of salivary glands with glycopyrronium bromide does not reduce the uptake of PSMA-ligands or radioiodine by Mohan, V., Bruin, N. M., Tesselaar, M. E. T., de Boer, J. P., Vegt, E., Hendrikx, J. J. M. A., Al-Mamgani, A., van de Kamer, J. B., Sonke, J.-J., Vogel, W. V.

“…Rationale Salivary glands are highly perfused and express the prostate-specific membrane antigen (PSMA) receptor as well as the sodium—iodide symporter. As a…”
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A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors by Siebinga, H., de Wit-van der Veen, B. J., Beijnen, J. H., Stokkel, M. P. M., Dorlo, T. P. C., Huitema, A. D. R., Hendrikx, J. J. M. A.

“…Background Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the…”
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Radiolabeling and quality control of therapeutic radiopharmaceuticals: optimization, clinical implementation and comparison of radio-TLC/HPLC analysis, demonstrated by [177Lu]Lu-PSMA by Hooijman, Eline L., Ntihabose, Carolline M., Reuvers, Thom G. A., Nonnekens, Julie, Aalbersberg, Else A., van de Merbel, Jordy R. J. P., Huijmans, Judith E., Koolen, Stijn L. W., Hendrikx, Jeroen J. M. A., de Blois, Erik

“…Background Radiopharmaceuticals are considered as regular medicinal products and therefore the same regulations as for non-radioactive medicinal products…”
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Quality control of [177Lu]Lu-PSMA preparations using HPLC: effect of sample composition and ligand on recovery by Aalbersberg, Else A., Cao, Tammie T., Geluk-Jonker, Martine M., Hendrikx, Jeroen J. M. A.

“…Background [ 177 Lu]Lu-PSMA is used for the treatment of metastatic castration-resistant prostate cancer. For in-house productions, quality control methods are…”
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Local-To-Global Hypotheses for Robust Robot Localization by Hendrikx, R. W. M., Bruyninckx, H., Elfring, J., Van De Molengraft, M. J. G.

“…Many robust state-of-the-art localization methods rely on pose-space sample sets that are evaluated against individual sensor measurements. While these methods…”
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Automated synthesis and quality control of [99mTc]Tc-PSMA for radioguided surgery (in a [68Ga]Ga-PSMA workflow) by Aalbersberg, Else A., van Andel, Lotte, Geluk-Jonker, Martine M., Beijnen, Jos H., Stokkel, Marcel P. M., Hendrikx, Jeroen J. M. A.

“…Background Lymph node dissection is a therapeutic option for prostate cancer patients with a high risk of- or proven lymph node metastases. Radioguided surgery…”
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