Search Results - "Hendrikx, Jeroen JMA"

Redispensing of expensive oral anticancer medicines: A practical application by Akgöl, Kübra, van Merendonk, Lisanne N, Barkman, Hannerieke J, van Balen, Dorieke EM, van den Hoek, Hester L, Klous, Marjolein G, Hendrikx, Jeroen JMA, Huitema, Alwin DR, Beijnen, Jos H, Nuijen, Bastiaan

“…Introduction Increasing use of expensive oral anticancer medicines comes with the downside of a financial and environmental burden, partially caused by unused…”
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Improving Appropriate Prescribing For Geriatric Patients Using a Clinical Decision Support System by Van den Hanenberg, Floor, Poetsema, Valentina, Keijsers, Carolina JPW, Hendrikx, Jeroen JMA, Van Campen, Jos, Meulendijk, Michiel C, Tichelaar, Jelle, Van Agtmael, Michiel A

“…Purpose: Polypharmacy is a known risk factor for potentially inappropriate prescribing. Recently there is an increasing interest in clinical decision support…”
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99mTcPSMA‐radioguided surgery in oligorecurrent prostate cancer: the randomised TRACE‐II trial by Zuur, Lotte G., Barros, Hilda A., Oosterom, Matthias N., Berrens, Anne‐Claire, Donswijk, Maarten L., Hendrikx, Jeroen J.M.A., Bekers, Elise M., Vis, André N., Wit, Esther M., Leeuwen, Fijs B., Poel, Henk G., Leeuwen, Pim J.

“…Objective To investigate whether combination treatment of prostate‐specific membrane antigen (PSMA)‐based radioguided surgery (RGS) with short‐term androgen…”
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Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel by Iusuf, Dilek, Hendrikx, Jeroen J.M.A., van Esch, Anita, van de Steeg, Evita, Wagenaar, Els, Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.

“…Organic anion transporting polypeptides (human: OATPs and mouse: Oatps) are uptake transporters with important roles in drug pharmacokinetics and toxicity. We…”
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P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel by Hendrikx, Jeroen J.M.A., Lagas, Jurjen S., Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H., Schinkel, Alfred H.

“…Paclitaxel is avidly transported by P‐glycoprotein (P‐gp/MDR1/ABCB1). This results in low oral bioavailability, which can be boosted by coadministration of…”
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A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir by de Weger, Vincent A., Stuurman, Frederik E., Hendrikx, Jeroen J.M.A., Moes, Johannes J., Sawicki, Emilia, Huitema, Alwin D.R., Nuijen, Bastiaan, Thijssen, Bas, Rosing, Hilde, Keessen, Marianne, Mergui-Roelvink, Marja, Beijnen, Jos H., Schellens, Jan H.M., Marchetti, Serena

“…Two solid dispersions of docetaxel (denoted ModraDoc001 capsule and ModraDoc006 tablet (both 10 mg)) were co-administered with 100 mg ritonavir (/r) and…”
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Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model by Hendrikx, Jeroen J.M.A., Lagas, Jurjen S., Song, Ji‐Ying, Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H., Rottenberg, Sven, Schinkel, Alfred H.

“…Docetaxel (Taxotere®) is currently used intravenously as an anticancer agent and is primarily metabolized by Cytochrome P450 3A (CYP3A). The HIV protease…”
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Genetically modified mouse models for oral drug absorption and disposition by Tang, Seng Chuan, Hendrikx, Jeroen JMA, Beijnen, Jos H, Schinkel, Alfred H

“…Highlights • Intestinal drug absorption can be limited by Mrp2, P-gp and Bcrp. • Octn1 and Octn2 may facilitate intestinal drug absorption. • Enterocyte…”
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P‑glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice by Tang, Seng Chuan, Kort, Anita, Cheung, Ka Lei, Rosing, Hilde, Fukami, Tatsuki, Durmus, Selvi, Wagenaar, Els, Hendrikx, Jeroen J. M. A, Nakajima, Miki, van Vlijmen, Bart J. M, Beijnen, Jos H, Schinkel, Alfred H

“…We aimed to clarify the roles of the multidrug-detoxifying proteins ABCB1, ABCG2, ABCC2, and CYP3A in oral availability and brain accumulation of cabazitaxel,…”
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A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry by Hendrikx, Jeroen J.M.A., Hillebrand, Michel J.X., Thijssen, Bas, Rosing, Hilde, Schinkel, Alfred H., Schellens, Jan H.M., Beijnen, Jos H.

“…► A validated LC–MS/MS method is described for the simultaneously quantification of paclitaxel, docetaxel and ritonavir. ► Drugs with diverse individual…”
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A Phase 1 Dose‐Escalation Study of Low‐Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors by Weger, Vincent A., Vermunt, Marit A.C., Stuurman, Frederik E., Burylo, Artur M., Damoiseaux, David, Hendrikx, Jeroen J.M.A., Sawicki, Emilia, Moes, Johannes J., Huitema, Alwin D.R., Nuijen, Bastiaan, Rosing, Hilde, Mergui‐Roelvink, Marja, Beijnen, Jos H., Marchetti, Serena

“…ModraPac001 (MP1) and ModraPac005 (MP5) are novel oral paclitaxel formulations that are coadministered with the cytochrome P450 3A4 inhibitor ritonavir (r),…”
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Is Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Letter] by Hendrikx, Jeroen J M A, Beijnen, Jos H, Huitema, Alwin D R

“…Jeroen JMA Hendrikx,1- 3 Jos H Beijnen,1 Alwin DR Huitema1- 3 1Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The…”
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