Search Results - "Hendrickson, Wayne A."

Anomalous diffraction in crystallographic phase evaluation by Hendrickson, Wayne A

“…X-ray diffraction patterns from crystals of biological macromolecules contain sufficient information to define atomic structures, but atomic positions are…”
Get more information

Structural Basis for Gating and Activation of RyR1 by des Georges, Amédée, Clarke, Oliver B., Zalk, Ran, Yuan, Qi, Condon, Kendall J., Grassucci, Robert A., Hendrickson, Wayne A., Marks, Andrew R., Frank, Joachim

“…The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel required for skeletal muscle contraction. Here, we present cryo-EM…”
Get full text

Facing the phase problem by Hendrickson, Wayne A

“…The marvel of X-ray crystallography is the beauty and precision of the atomic structures deduced from diffraction patterns. Since these patterns record only…”
Get full text

Structure of a mammalian ryanodine receptor by Zalk, Ran, Clarke, Oliver B., des Georges, Amédée, Grassucci, Robert A., Reiken, Steven, Mancia, Filippo, Hendrickson, Wayne A., Frank, Joachim, Marks, Andrew R.

“…Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca 2+ ) from intracellular stores into the cytosol, which is essential for numerous cellular…”
Get full text

Structure and activity of lipid bilayer within a membrane-protein transporter by Qiu, Weihua, Fu, Ziao, Xu, Guoyan G., Grassucci, Robert A., Zhang, Yan, Frank, Joachim, Hendrickson, Wayne A., Guo, Youzhong

“…Membrane proteins function in native cell membranes, but extraction into isolated particles is needed for many biochemical and structural analyses. Commonly…”
Get full text

Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins by Fiumara, Ferdinando, Fioriti, Luana, Kandel, Eric R., Hendrickson, Wayne A.

“…The functional switch of glutamine/asparagine (Q/N)-rich prions and the neurotoxicity of polyQ-expanded proteins involve complex aggregation-prone structural…”
Get full text

Crystallographic phasing from weak anomalous signals by Liu, Qun, Hendrickson, Wayne A

“…•Crystal handling to reduce damage, variations and background.•Beamline instrumentation and data collection strategies for weak anomalous signals.•High…”
Get full text

Structure and activity of tryptophan-rich TSPO proteins by Guo, Youzhong, Kalathur, Ravi C., Liu, Qun, Kloss, Brian, Bruni, Renato, Ginter, Christopher, Kloppmann, Edda, Rost, Burkhard, Hendrickson, Wayne A.

“…Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic…”
Get full text

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP by Qi, Ruifeng, Sarbeng, Evans Boateng, Liu, Qun, Le, Katherine Quynh, Xu, Xinping, Xu, Hongya, Yang, Jiao, Wong, Jennifer Li, Vorvis, Christina, Hendrickson, Wayne A, Zhou, Lei, Liu, Qinglian

“…The 70-kDa heat-shock protein 70 (Hsp70) molecular chaperones have a nucleotide binding domain and a substrate binding domain that become allosterically…”
Get full text

Structures and gating mechanisms of human bestrophin anion channels by Owji, Aaron P., Wang, Jiali, Kittredge, Alec, Clark, Zada, Zhang, Yu, Hendrickson, Wayne A., Yang, Tingting

“…Bestrophin-1 (Best1) and bestrophin-2 (Best2) are two members of the bestrophin family of calcium (Ca 2+ )-activated chloride (Cl − ) channels with critical…”
Get full text

Structural Characterization of the Predominant Family of Histidine Kinase Sensor Domains by Zhang, Zhen, Hendrickson, Wayne A.

“…Histidine kinase (HK) receptors are used ubiquitously by bacteria to monitor environmental changes, and they are also prevalent in plants, fungi, and other…”
Get full text

Structure of the STRA6 receptor for retinol uptake by Chen, Yunting, Clarke, Oliver B., Kim, Jonathan, Stowe, Sean, Kim, Youn-Kyung, Assur, Zahra, Cavalier, Michael, Godoy-Ruiz, Raquel, von Alpen, Desiree C., Manzini, Chiara, Blaner, William S., Frank, Joachim, Quadro, Loredana, Weber, David J., Shapiro, Lawrence, Hendrickson, Wayne A., Mancia, Filippo

“…Vitamin A homeostasis is critical to normal cellular function. Retinol-binding protein (RBP) is the sole specific carrier in the bloodstream for hydrophobic…”
Get full text

Structure and selectivity in bestrophin ion channels by Yang, Tingting, Liu, Qun, Kloss, Brian, Bruni, Renato, Kalathur, Ravi C., Guo, Youzhong, Kloppmann, Edda, Rost, Burkhard, Colecraft, Henry M., Hendrickson, Wayne A.

“…Human bestrophin-1 (hBest1) is a calcium-activated chloride channel from the retinal pigment epithelium, where mutations are associated with vitelliform…”
Get full text

Structures of the colossal RyR1 calcium release channel by Clarke, Oliver B, Hendrickson, Wayne A

“…•Extended α-solenoid domains form a cytosolic scaffold with a core–shell structure.•The transmembrane pore is reminiscent of Kv/Nav channels, with unique…”
Get full text

Structure of human GABAB receptor in an inactive state by Park, Jinseo, Fu, Ziao, Frangaj, Aurel, Liu, Jonathan, Mosyak, Lidia, Shen, Tong, Slavkovich, Vesna N., Ray, Kimberly M., Taura, Jaume, Cao, Baohua, Geng, Yong, Zuo, Hao, Kou, Yongjun, Grassucci, Robert, Chen, Shaoxia, Liu, Zheng, Lin, Xin, Williams, Justin P., Rice, William J., Eng, Edward T., Huang, Rick K., Soni, Rajesh K., Kloss, Brian, Yu, Zhiheng, Javitch, Jonathan A., Hendrickson, Wayne A., Slesinger, Paul A., Quick, Matthias, Graziano, Joseph, Yu, Hongtao, Fiehn, Oliver, Clarke, Oliver B., Frank, Joachim, Fan, Qing R.

“…The human GABA B receptor—a member of the class C family of G-protein-coupled receptors (GPCRs)—mediates inhibitory neurotransmission and has been implicated…”
Get full text

An Asymmetry-to-Symmetry Switch in Signal Transmission by the Histidine Kinase Receptor for TMAO by Moore, Jason O., Hendrickson, Wayne A.

“…The osmoregulator trimethylamine-N-oxide (TMAO), commonplace in aquatic organisms, is used as the terminal electron acceptor for respiration in many bacterial…”
Get full text

Structures from Anomalous Diffraction of Native Biological Macromolecules by Liu, Qun, Dahmane, Tassadite, Zhang, Zhen, Assur, Zahra, Brasch, Julia, Shapiro, Lawrence, Mancia, Filippo, Hendrickson, Wayne A.

“…Crystal structure analyses for biological macromolecules without known structural relatives entail solving the crystallographic phase problem. Typical de novo…”
Get full text

Promiscuous Substrate Recognition in Folding and Assembly Activities of the Trigger Factor Chaperone by Martinez-Hackert, Erik, Hendrickson, Wayne A.

“…Trigger factor (TF) is a molecular chaperone that binds to bacterial ribosomes where it contacts emerging nascent chains, but TF is also abundant free in the…”
Get full text

Structure and activity of SLAC1 channels for stomatal signaling in leaves by Deng, Ya-nan, Kashtoh, Hamdy, Wang, Quan, Zhen, Guang-xiao, Li, Qi-yu, Tang, Ling-hui, Gao, Hai-long, Zhang, Chun-rui, Qin, Li, Su, Min, Li, Fei, Huang, Xia-he, Wang, Ying-chun, Xie, Qi, Clarke, Oliver B., Hendrickson, Wayne A., Chen, Yu-hang

“…Stomata in leaves regulate gas exchange between the plant and its atmosphere. Various environmental stimuli elicit abscisic acid (ABA); ABA leads to…”
Get full text

Structural Analysis of Ligand Stimulation of the Histidine Kinase NarX by Cheung, Jonah, Hendrickson, Wayne A.

“…Histidine kinase receptors are a large family of membrane-spanning proteins found in many prokaryotes and some eukaryotes. They are a part of two-component…”
Get full text