Search Results - "Hendrickson, T F"

Structure-Assisted Design of Mechanism-Based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity against Multiple Rhinovirus Serotypes by Matthews, D A, Dragovich, P S, Webber, S E, Fuhrman, S A, Patick, A K, Zalman, L S, Hendrickson, T F, Love, R A, Prins, T J, Marakovits, J T, Zhou, R, Tikhe, J, Ford, C E, Meador, J W, Ferre, R A, Brown, E L, Binford, S L, Brothers, M A, DeLisle, D M, Worland, S T

“…Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a…”
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Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease by Webber, Stephen E., Tikhe, Jayashree, Worland, Stephen T., Fuhrman, Shella A., Hendrickson, Thomas F., Matthews, David A., Love, Robert A., Patick, Amy K., Meador, James W., Ferre, Rose Ann, Brown, Edward L., DeLisle, Dorothy M., Ford, Clifford E., Binford, Susan L.

“…The design, synthesis, and biological evaluation of reversible, nonpeptidic inhibitors of human rhinovirus (HRV) 3C protease (3CP) are reported. A novel series…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as l-Glutamine Replacements by Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Webber, Stephen E, Marakovits, Joseph T, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Ford, Clifford E, Burke, Benjamin J, Rejto, Paul A, Hendrickson, Thomas F, Tuntland, Tove, Brown, Edward L, Meador, James W, Ferre, Rose Ann, Harr, James E. V, Kosa, Maha B, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of various human rhinovirus (HRV) 3C protease (3CP) inhibitors which incorporate P1…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics by Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Brown, Edward L, Maldonado, Fausto C, Fuhrman, Shella A, Zalman, Leora S, Tuntland, Tove, Lee, Caroline A, Patick, Amy K, Matthews, David A, Hendrickson, Thomas F, Kosa, Maha B, Liu, Bo, Batugo, Minerva R, Gleeson, Jean-Paul R, Sakata, Sylvie K, Chen, Lijian, Guzman, Mark C, Meador, James W, Ferre, Rose Ann, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors…”
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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease:  Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements by Webber, Stephen E, Okano, Koji, Little, Thomas L, Reich, Siegfried H, Xin, Yue, Fuhrman, Shella A, Matthews, David A, Love, Robert A, Hendrickson, Thomas F, Patick, Amy K, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Ford, Clifford E, Binford, Susan L, Worland, Stephen T

“…The investigation of tripeptide aldehydes as reversible covalent inhibitors of human rhinovirus (HRV) 3C protease (3CP) is reported. Molecular models based on…”
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Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease:  Structure-Based Design, Synthesis, and Biological Evaluation by Reich, Siegfried H, Johnson, Theodore, Wallace, Michael B, Kephart, Susan E, Fuhrman, Shella A, Worland, Stephen T, Matthews, David A, Hendrickson, Thomas F, Chan, Fora, Meador, James, Ferre, Rose Ann, Brown, Edward L, DeLisle, Dorothy M, Patick, Amy K, Binford, Susan L, Ford, Clifford E

“…A series of nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease was identified using structure-based design. The design,…”
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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein by Ganguly, Ashit K, Wang, Yu-Sen, Pramanik, Birendra N, Doll, Ronald J, Snow, Mark E, Taveras, Arthur G, Remiszewski, Stacy, Cesarz, David, del Rosario, J, Vibulbhan, Bancha, Brown, Joan E, Kirschmeier, Paul, Huang, Eric C, Heimark, Larry, Tsarbopoulos, Anthony, Girijavallabhan, Viyyoor M, Aust, Robert M, Brown, Edward L, DeLisle, Dorothy M, Fuhrman, Shella A, Hendrickson, Thomas F, Kissinger, Charles R, Love, Robert A, Sisson, Wess A, Villafranca, J. Ernest, Webber, Steve E

“…Mutated, tumorigenic Ras is present in a variety of human tumors. Compounds that inhibit tumorigenic Ras function may be useful in the treatment of Ras-related…”
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Experimental and computer modeling studies of micellar diastereoselectivity by Moss, Robert A, Hendrickson, Thomas F, Ueoka, Ryuichi, Kim, Kwang Yoo, Weiner, Paul K

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Backbone entropy of loops as a measure of their flexibility: Application to a Ras protein simulated by molecular dynamics by Meirovitch, Hagai, Hendrickson, Thomas F.

“…The flexibility of surface loops plays an important role in protein–protein and protein–peptide recognition; it is commonly studied by Molecular Dynamics or…”
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Esterolytic chemistry of vesicular thiocholine surfactant by Moss, Robert A, Hendrickson, Thomas F, Bizzigotti, George O

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P 1 Lactam Moieties as l -Glutamine Replacements by Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Webber, Stephen E., Marakovits, Joseph T., Fuhrman, Shella A., Patick, Amy K., Matthews, David A., Lee, Caroline A., Ford, Clifford E., Burke, Benjamin J., Rejto, Paul A., Hendrickson, Thomas F., Tuntland, Tove, Brown, Edward L., Meador, James W., Ferre, Rose Ann, Harr, James E. V., Kosa, Maha B., Worland, Stephen T.

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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease:  Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P 1 Glutamine Isosteric Replacements by Webber, Stephen E., Okano, Koji, Little, Thomas L., Reich, Siegfried H., Xin, Yue, Fuhrman, Shella A., Matthews, David A., Love, Robert A., Hendrickson, Thomas F., Patick, Amy K., Meador, James W., Ferre, Rose Ann, Brown, Edward L., Ford, Clifford E., Binford, Susan L., Worland, Stephen T.

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P sub(1) Lactam Moieties as L-Glutamine Replacements by Dragovich, P S, Prins, T J, Zhou, Ru, Webber, SE, Marakovits, J T, Fuhrman, SA, Patick, A K, Matthews, DA, Lee, CA, d, CE, Burke, B J, Rejto, P A, Hendrickson, T F, Tuntland, T

“…The structure-based design, chemical synthesis, and biological evaluation of various human rhinovirus (HRV) 3C protease (3CP) inhibitors which incorporate P…”
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Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease by Johnson, Theodore O, Hua, Ye, Luu, Hiep T, Brown, Edward L, Chan, Fora, Chu, Shao Song, Dragovich, Peter S, Eastman, Brian W, Ferre, Rose Ann, Fuhrman, Shella A, Hendrickson, Thomas F, Maldonado, Fausto C, Matthews, David A, Meador, James W, Patick, Amy K, Reich, Siegfried H, Skalitzky, Donald J, Worland, Stephen T, Yang, Michelle, Zalman, Leora S

“…Utilizing the tools of parallel synthesis and structure-based design, a new class of Michael acceptor-containing, irreversible inhibitors of human rhinovirus…”
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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P sub(1) Glutamine Isosteric Replacements by Webber, SE, Okano, K, Little, T L, Reich, SH, Xin, Y, Fuhrman, SA, Matthews, DA, Love, R A, Hendrickson, T F, Patick, A K, Meador, JW III, Ferre, R A, Brown, EL, d, CE

“…The investigation of tripeptide aldehydes as reversible covalent inhibitors of human rhinovirus (HRV) 3C protease (3CP) is reported. Molecular models based on…”
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Electrostatic contributions to solvation energies: comparison of free energy perturbation and continuum calculations by Jean-Charles, Arald, Nicholls, Anthony, Sharp, Kim, Honig, Barry, Tempczyk, Anna, Hendrickson, Thomas F, Still, W. Clark

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Electrostatic contributions ot solvation energies : comparison of free energy perturbation and continuum calculations by JEAN-CHARLES, A, NICHOLLS, A, SHARP, K, HONIG, B, TEMPCZYK, A, HENDRICKSON, T. F, STILL, W. C

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