Search Results - "Hendrickson, Howard P."

Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin by Pouncey, Dakota L, Barnette, Dustyn A, Sinnott, Riley W, Phillips, Sarah J, Flynn, Noah R, Hendrickson, Howard P, Swamidass, S Joshua, Miller, Grover P

“…Coumadin (R/S-warfarin) anticoagulant therapy is highly efficacious in preventing the formation of blood clots; however, significant inter-individual…”
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Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats by Hambuchen, Michael D, Berquist, Michael D, Simecka, Christy M, McGill, Mitchell R, Gunnell, Melinda G, Hendrickson, Howard P, Owens, S Michael

“…Methamphetamine (METH) abuse is associated with hepatic dysfunction related comorbidities such as HIV, hepatitis C, and polysubstance abuse with…”
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Development and preclinical testing of a high-affinity single-chain antibody against (+)-methamphetamine by Peterson, Eric C, Laurenzana, Elizabeth M, Atchley, William T, Hendrickson, Howard P, Owens, S Michael

“…Chronic or excessive (+)-methamphetamine (METH) use often leads to addiction and toxicity to critical organs like the brain. With medical treatment as a goal,…”
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Determination of Acetaminophen-Protein Adducts in Mouse Liver and Serum and Human Serum after Hepatotoxic Doses of Acetaminophen Using High-Performance Liquid Chromatography with Electrochemical Detection by MULDREW, Kenneth L, JAMES, Laura P, COOP, Leslie, MCCULLOUGH, Sandra S, HENDRICKSON, Howard P, HINSON, Jack A, MAYEUX, Philip R

“…Acetaminophen-induced hepatotoxicity has been attributed to covalent binding of the reactive metabolite N -acetyl- p -benzoquinone imine to cysteine groups on…”
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Development and validation of a rapid liquid chromatography/tandem mass spectrometry method to quantitate gabapentin and buprenorphine in human serum by Phillips, Sarah J., Oliveto, Alison, Mancino, Michael J., Hendrickson, Howard P.

“…Rationale Gabapentin has shown initial promise as an opioid‐sparing medication in pain patients as well as a treatment for opioid withdrawal and liquid…”
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Vulnerability to (+)-Methamphetamine Effects and the Relationship to Drug Disposition in Pregnant Rats during Chronic Infusion by White, Sarah J., Laurenzana, Elizabeth M., Gentry, William Brooks, Hendrickson, Howard P., Williams, David Keith, Ward, Keith W., Owens, Samuel Michael

“…Chronic (+)-methamphetamine (METH) use during pregnancy increases the health risk for both mother and fetus. To provide insights into these risks, the…”
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Amberlite IR-120H as an efficient and versatile solid phase catalyst for nucleophilic substitution of propargylic alcohols by Gujarathi, Satheesh, Hendrickson, Howard P., Zheng, Guangrong

“…A highly efficient Amberlite IR-120H resin mediated nucleophilic substitution of the hydroxyl group of propargylic alcohols with a wide range of nucleophiles…”
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Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates by Wang, Junru, Shao, Lijian, Hendrickson, Howard P., Liu, Liya, Chang, Jianhui, Luo, Yi, Seng, John, Pouliot, Mylene, Authier, Simon, Zhou, Daohong, Allaben, William, Hauer-Jensen, Martin

“…The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the…”
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The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats by Hambuchen, Michael D., Hendrickson, Howard P., Gunnell, Melinda G., McClenahan, Samantha J., Ewing, Laura E., Gibson, Dillon M., Berquist, Michael D., Owens, S. Michael

“…•First report of sex-dependent (R,S)-methylenedioxypyrovalerone (MDPV) and enantiomer differences in pharmacokinetics (PK).•Males had significantly greater…”
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Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans by Gupta, Prem K, Barone, Gary, Gurley, Bill J, Fifer, E Kim, Hendrickson, Howard P

“…The disposition and metabolism of hydrastine was investigated in 11 healthy subjects following an oral dose of 2.7 g of goldenseal supplement containing 78 mg…”
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Determination of dextromethorphan and its metabolites in rat serum by liquid–liquid extraction and liquid chromatography with fluorescence detection by Hendrickson, Howard P., Gurley, Bill J., Wessinger, William D.

“…Dextromethorphan is an effective and safe antitussive, but has liabilities with respect to its abuse potential at doses above the therapeutic dose. At these…”
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Preparation of 4,5 disubstituted-2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles by Madadi, Nikhil Reddy, Penthala, Narsimha Reddy, Song, Lin, Hendrickson, Howard P., Crooks, Peter A.

“…2H-1,2,3-Triazoles (2) were synthesized by [3+2] cycloaddition of (Z)-2,3-diaryl substituted acrylonitriles (1) with sodium azide and ammonium chloride in…”
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Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response by Hambuchen, Michael D, Carroll, F. Ivy, Rüedi-Bettschen, Daniela, Hendrickson, Howard P, Hennings, Leah J, Blough, Bruce E, Brieaddy, Lawrence E, Pidaparthi, Ramakrishna R, Owens, S. Michael

“…We hypothesized that an anti-METH mAb could be used in combination with a METH-conjugate vaccine (MCV) to safely improve the overall quality and magnitude of…”
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A pharmacokinetic study of morphine‐6‐O‐sulfate in rat plasma and brain by Yadlapalli, Jai Shankar K., Albayati, Zaineb A. F., Breen, Philip J., Dobretsov, Maxim, Penthala, Narsimha R., Hendrickson, Howard P., Crooks, Peter A.

“…Morphine‐6‐O‐sulfate (M6S), a polar, zwitterionic sulfate ester of morphine, is a powerful and safe analgesic in several rat models of pain. A sensitive liquid…”
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Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses by Pathak, Rupak, Pawar, Snehalata A, Fu, Qiang, Gupta, Prem K, Berbée, Maaike, Garg, Sarita, Sridharan, Vijayalakshmi, Wang, Wenze, Biju, Prabath G, Krager, Kimberly J, Boerma, Marjan, Ghosh, Sanchita P, Cheema, Amrita K, Hendrickson, Howard P, Aykin-Burns, Nukhet, Hauer-Jensen, Martin

“…The free radical scavenger and nitric oxide synthase cofactor, 5,6,7,8-tetrahydrobiopterin (BH4), plays a well-documented role in many disorders associated…”
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Stability studies of potent opioid analgesic, morphine‐6‐O‐sulfate in various buffers and biological matrices by HPLC‐DAD analysis by Yadlapalli, Jai Shankar K., Albayati, Zaineb A.F., Penthala, Narasimha R., Hendrickson, Howard P., Crooks, Peter A.

“…The 6‐O‐sulfate ester of morphine (M6S) has previously been shown to be an analgesic with greater potency and fewer side effects than morphine. However, being…”
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Therapeutic Anti-Methamphetamine Antibody Fragment-Nanoparticle Conjugates: Synthesis and in Vitro Characterization by Nanaware-Kharade, Nisha, Gonzalez, Guillermo A, Lay, Jackson O, Hendrickson, Howard P, Peterson, Eric C

“…Treatments specific to the medical problems caused by methamphetamine (METH) abuse are greatly needed. Toward this goal, we are developing new multivalent…”
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Treatment with a monoclonal antibody against methamphetamine and amphetamine reduces maternal and fetal rat brain concentrations in late pregnancy by White, Sarah J, Hendrickson, Howard P, Atchley, William T, Laurenzana, Elizabeth M, Gentry, W Brooks, Williams, D Keith, Owens, S Michael

“…We hypothesized that treatment of pregnant rat dams with a dual reactive monoclonal antibody (mAb4G9) against (+)-methamphetamine [METH; equilibrium…”
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases by Greer, Aleksandra K, Madadi, Nikhil R, Bratton, Stacie M, Eddy, Sarah D, Mazerska, Zofia, Hendrickson, Howard P, Crooks, Peter A, Radominska-Pandya, Anna

“…Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a…”
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Validation of a liquid chromatography–tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum by Gupta, Prem K., Hubbard, Martha, Gurley, Bill, Hendrickson, Howard P.

“…A high throughput liquid chromatography/tandem mass spectrometry (LC–MS/MS) method for the simultaneous determination of berberine and hydrastine in human…”
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