Search Results - "Hendrickson, F"

Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors by Ho, Koc-Kan, Parnell, K. Mark, Yuan, Yi, Xu, Yong, Kultgen, Steven G, Hamblin, Steven, Hendrickson, Thomas F, Luo, Bai, Foulks, Jason M, McCullar, Michael V, Kanner, Steven B

“…A series of compounds based on a 4-phenyl-2-phenylaminopyridine scaffold that are potent and selective inhibitors of Traf2- and Nck-interacting kinase (TNIK)…”
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Structure-Assisted Design of Mechanism-Based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity against Multiple Rhinovirus Serotypes by Matthews, D A, Dragovich, P S, Webber, S E, Fuhrman, S A, Patick, A K, Zalman, L S, Hendrickson, T F, Love, R A, Prins, T J, Marakovits, J T, Zhou, R, Tikhe, J, Ford, C E, Meador, J W, Ferre, R A, Brown, E L, Binford, S L, Brothers, M A, DeLisle, D M, Worland, S T

“…Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics by Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Brown, Edward L, Maldonado, Fausto C, Fuhrman, Shella A, Zalman, Leora S, Tuntland, Tove, Lee, Caroline A, Patick, Amy K, Matthews, David A, Hendrickson, Thomas F, Kosa, Maha B, Liu, Bo, Batugo, Minerva R, Gleeson, Jean-Paul R, Sakata, Sylvie K, Chen, Lijian, Guzman, Mark C, Meador, James W, Ferre, Rose Ann, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors…”
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Weight Change and the Risk of Gestational Diabetes in Obese Women by Glazer, Nicole L., Hendrickson, Audrey F., Schellenbaum, Gina D., Mueller, Beth A.

“…Background: Obesity is an established risk factor for gestational diabetes. It is not known whether this risk might be reduced through weight loss between…”
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The epidemiology of narcolepsy by LONGSTRETH, W. T, KOEPSELL, Thomas D, TON, Thanh G, HENDRICKSON, Audrey F, VAN BELLE, Gerald

“…Much has been learned about the pathophysiology of narcolepsy over the last several decades. It is likely that hypocretin-producing cells in the lateral…”
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Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease by Webber, Stephen E., Tikhe, Jayashree, Worland, Stephen T., Fuhrman, Shella A., Hendrickson, Thomas F., Matthews, David A., Love, Robert A., Patick, Amy K., Meador, James W., Ferre, Rose Ann, Brown, Edward L., DeLisle, Dorothy M., Ford, Clifford E., Binford, Susan L.

“…The design, synthesis, and biological evaluation of reversible, nonpeptidic inhibitors of human rhinovirus (HRV) 3C protease (3CP) are reported. A novel series…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as l-Glutamine Replacements by Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Webber, Stephen E, Marakovits, Joseph T, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Ford, Clifford E, Burke, Benjamin J, Rejto, Paul A, Hendrickson, Thomas F, Tuntland, Tove, Brown, Edward L, Meador, James W, Ferre, Rose Ann, Harr, James E. V, Kosa, Maha B, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of various human rhinovirus (HRV) 3C protease (3CP) inhibitors which incorporate P1…”
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Long-Term Outcomes of Total Knee Arthroplasty following Soft-Tissue Defect Reconstruction with Muscle and Fasciocutaneous Flaps by Kwiecien, Grzegorz J., Lamaris, Gregory, Gharb, Bahar Bassiri, Murray, Trevor, Hendrickson, Mark F., Zins, James E., Isakov, Raymond

“…Insufficient soft-tissue coverage following total knee arthroplasty jeopardizes prosthesis retention and may lead to significant complications. The aim of this…”
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Epigenetic drug discovery: targeting DNA methyltransferases by Foulks, Jason M, Parnell, K Mark, Nix, Rebecca N, Chau, Suzanna, Swierczek, Krzysztof, Saunders, Michael, Wright, Kevin, Hendrickson, Thomas F, Ho, Koc-Kan, McCullar, Michael V, Kanner, Steven B

“…Epigenetic modification of DNA leads to changes in gene expression. DNA methyltransferases (DNMTs) comprise a family of nuclear enzymes that catalyze the…”
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Teaching Determinants Using Rook Arrangements by Hendrickson, Anders O. F.

“…Teaching determinants poses significant challenges to the instructor of a proof-based undergraduate linear algebra course. The standard definition by cofactor…”
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Abstract 50: Occlusal & Dental Outcomes Following Facial Allotransplantation by Coombs, Demetrius M., Tuncer, Fatma B., Gharb, Bahar B., Djohan, Risal, Gastman, Brian, Bernard, Steven, Hendrickson, Mark F., Schwarz, Graham, Gurunian, Raffi, Siemionow, Maria, Papay, Francis, Rampazzo, Antonio

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Performance of a 2k CCD camera designed for electron crystallography at 400 kV by Downing, Kenneth H., Hendrickson, Felicia M.

“…We discuss the performance of a charge-coupled device (CCD) camera that has been designed for use in electron crystallographic studies of proteins. There have…”
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Maximizing the Reach of the Pedicled Gastrocnemius Muscle Flap: A Comparison of 2 Surgical Approaches by Lamaris, Gregory A, Carlisle, Michael P, Durand, Paul, Couto, Rafael A, Hendrickson, Mark F

“…BACKGROUNDThe medial gastrocnemius muscle flap is commonly used for the reconstruction of defects around the knee and proximal leg. The flap can be raised…”
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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease:  Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements by Webber, Stephen E, Okano, Koji, Little, Thomas L, Reich, Siegfried H, Xin, Yue, Fuhrman, Shella A, Matthews, David A, Love, Robert A, Hendrickson, Thomas F, Patick, Amy K, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Ford, Clifford E, Binford, Susan L, Worland, Stephen T

“…The investigation of tripeptide aldehydes as reversible covalent inhibitors of human rhinovirus (HRV) 3C protease (3CP) is reported. Molecular models based on…”
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Radial Artery Use in Bypass Grafting Does Not Change Digital Blood Flow or Hand Function by Dumanian, Gregory A, Segalman, Keith, Mispireta, Luis A, Walsh, John A, Hendrickson, Mark F, Wilgis, E.F.Shaw

“…Background. Patient selection criteria have not been clearly established for use of the radial artery as a bypass conduit. To help establish such criteria, we…”
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Soft Tissue Reconstruction for Deep Defects over a Complicated Total Knee Arthroplasty: A Systematic Review by Coombs, Demetrius M, Churchill, Jessica, Cartwright, Paul, Chughtai, Morad, Sultan, Assem A, Samuel, Linsen T, Moskal, Joseph T, Hendrickson, Mark F, Mont, Michael A

“…Deep soft tissue defects after complicated primary or revision total knee arthroplasty (TKA) can be devastating to the patient and technically challenging. The…”
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Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2) by Xu, Yong, Liu, Xiao-Hui, Saunders, Michael, Pearce, Scott, Foulks, Jason M., Parnell, K. Mark, Clifford, Adrianne, Nix, Rebecca N., Bullough, Jeremy, Hendrickson, Thomas F., Wright, Kevin, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan

“…Activators of the pyruvate kinase M2 (PKM2) are currently attracting significant interest as potential anticancer therapies. They may achieve a novel…”
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Electrostatic contributions to solvation energies: comparison of free energy perturbation and continuum calculations by Jean-Charles, Arald, Nicholls, Anthony, Sharp, Kim, Honig, Barry, Tempczyk, Anna, Hendrickson, Thomas F, Still, W. Clark

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Long Term Outcomes of Total Knee Arthroplasty Following Soft Tissue Defect Reconstruction with Flaps by Kwiecien, Grzegorz, Lamaris, Gregory, Gharb, Bahar Bassiri, Murray, Trevor, Hendrickson, Mark F., Zins, James E., Isakov, Raymond

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Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease:  Structure-Based Design, Synthesis, and Biological Evaluation by Reich, Siegfried H, Johnson, Theodore, Wallace, Michael B, Kephart, Susan E, Fuhrman, Shella A, Worland, Stephen T, Matthews, David A, Hendrickson, Thomas F, Chan, Fora, Meador, James, Ferre, Rose Ann, Brown, Edward L, DeLisle, Dorothy M, Patick, Amy K, Binford, Susan L, Ford, Clifford E

“…A series of nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease was identified using structure-based design. The design,…”
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