Search Results - "Hendricks, RL"

Herpes Simplex Virus-Specific Memory CD8 + T Cells Are Selectively Activated and Retained in Latently Infected Sensory Ganglia by Khanna, Kamal M., Bonneau, Robert H., Kinchington, Paul R., Hendricks, Robert L.

“…This study challenges the concept that herpes simplex virus type 1 (HSV-1) latency represents a silent infection that is ignored by the host immune system, and…”
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Identification of a Novel Macrophage Population in the Normal Mouse Corneal Stroma by Brissette-Storkus, Cynthia S, Reynolds, Stephanie M, Lepisto, Andrew J, Hendricks, Robert L

“…To examine the normal murine corneal stroma for the presence of bone marrow-derived leukocytes. Wholemounts of paraformaldehyde-fixed corneal stroma from…”
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CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons by Liu, T, Khanna, K M, Chen, X, Fink, D J, Hendricks, R L

“…Recurrent herpes simplex virus type 1 (HSV-1) disease usually results from reactivation of latent virus in sensory neurons and transmission to peripheral…”
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Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression by DECMAN, Vilma, KINCHINGTON, Paul R, HARVEY, Stephen A. K, HENDRICKS, Robert L

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Gamma Interferon Can Prevent Herpes Simplex Virus Type 1 Reactivation from Latency in Sensory Neurons by Liu, T, Khanna, K M, Carriere, B N, Hendricks, R L

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Immune control of herpes simplex virus during latency by Khanna, Kamal M, Lepisto, Andrew J, Decman, Vilma, Hendricks, Robert L

“…Herpes simplex virus type 1 (HSV-1) persists within the host in the presence of concomitant immunity by establishing a latent infection within sensory neurons…”
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Infected cell protein (ICP)47 enhances herpes simplex virus neurovirulence by blocking the CD8+ T cell response by Goldsmith, K, Chen, W, Johnson, D C, Hendricks, R L

“…The herpes simplex virus (HSV) infected cell protein (ICP)47 blocks CD8+ T cell recognition of infected cells by inhibiting the transporter associated with…”
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Immunity to latent viral infection: many skirmishes but few fatalities by Khanna, Kamal M., Lepisto, Andrew J., Hendricks, Robert L.

“…During early childhood, herpes simplex virus type 1 (HSV-1) can establish a latent infection in sensory neurons, which then serves as a reservoir of the virus…”
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Macrophage Control of Herpes Simplex Virus Type 1 Replication in the Peripheral Nervous System by Kodukula, Padma, Liu, Ting, Rooijen, Nico Van, Jager, Martine J, Hendricks, Robert L

“…After corneal infection, herpes simplex virus type 1 (HSV-1) invades sensory neurons with cell bodies in the trigeminal ganglion (TG), replicates briefly, and…”
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Immune control of HSV-1 latency by Decman, Vilma, Freeman, Michael L, Kinchington, Paul R, Hendricks, Robert L

“…A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent…”
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Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas by Tang, Q, Hendricks, R L

“…In a mouse model of herpes simplex virus (HSV) 1 corneal infection, tissue destruction results from a CD4+ T cell-mediated chronic inflammation, in which…”
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Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection by Liu, T, Tang, Q, Hendricks, R L

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T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis by Sciammas, R, Kodukula, P, Tang, Q, Hendricks, R L, Bluestone, J A

“…Increased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influenza and sendai virus infections, as well as in…”
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CD154 Signaling Regulates the Th1 Response to Herpes Simplex Virus-1 and Inflammation in Infected Corneas by Xu, Min, Lepisto, Andrew J, Hendricks, Robert L

“…Approximately 7 days after HSV-1 corneal infection, BALB/c mice develop tissue-destructive inflammation in the cornea termed herpes stromal keratitis (HSK), as…”
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Sensory neurons regulate the effector functions of CD8+ T cells in controlling HSV-1 latency ex vivo by Prabhakaran, Kartik, Sheridan, Brian S, Kinchington, Paul R, Khanna, Kamal M, Decman, Vilma, Lathrop, Kira, Hendricks, Robert L

“…We provide evidence that sensory neurons regulate the effector functions and phenotype of CD8+ T cells during active immunosurveillance of HSV-1 latency…”
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Proinflammatory functions of IL-2 in herpes simplex virus corneal infection by Tang, Q, Chen, W, Hendricks, RL

“…Herpes simplex virus type 1 infection of corneas can lead to blinding inflammation in the corneal stroma, which is referred to clinically as herpes stromal…”
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IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice by Hendricks, RL, Tumpey, TM, Finnegan, A

“…HSV type 1 (HSV-1) infection of the mouse cornea results in a tissue-destructive inflammatory reaction in the cornea, but little or no disease in the skin…”
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B7 Costimulatory Requirements of T Cells at an Inflammatory Site by Chen, Haixiao, Hendricks, Robert L

“…The requirement for T cell costimulation at sites of infection and inflammation is unresolved. Herpes stromal keratitis (HSK) is a CD4+ T cell-regulated…”
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An immunologist's view of herpes simplex keratitis: Thygeson Lecture 1996, presented at the Ocular Microbiology and Immunology Group meeting, October 26, 1996 by Hendricks, R L

“…To review recent progress in understanding the mechanisms of herpes simplex virus 1 (HSV-1)-induced immunopathology in the cornea, as revealed by studies in a…”
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Critical role of corneal Langerhans cells in the CD4- but not CD8- mediated immunopathology in herpes simplex virus-1-infected mouse corneas by Hendricks, RL, Janowicz, M, Tumpey, TM

“…Previous studies have revealed that the RE strain of HSV type 1 (HSV-1) induces a tissue-destructive inflammatory response in the mouse cornea that is mediated…”
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