Search Results - "Henderson, Joel"

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis by Kramann, Rafael, Schneider, Rebekka K., DiRocco, Derek P., Machado, Flavia, Fleig, Susanne, Bondzie, Philip A., Henderson, Joel M., Ebert, Benjamin L., Humphreys, Benjamin D.

“…Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues…”
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Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology by Watts, Andrew J B, Keller, Keith H, Lerner, Gabriel, Rosales, Ivy, Collins, A Bernard, Sekulic, Miroslav, Waikar, Sushrut S, Chandraker, Anil, Riella, Leonardo V, Alexander, Mariam P, Troost, Jonathan P, Chen, Junbo, Fermin, Damian, Yee, Jennifer L, Sampson, Matthew G, Beck, Jr, Laurence H, Henderson, Joel M, Greka, Anna, Rennke, Helmut G, Weins, Astrid

“…Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The…”
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Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes by Patterson, Heide Christine, Henderson, Joel M, Zhang, Baochun, Kutok, Jeffrey L, Srinivasan, Lakshmi, Wang, Jing, Calado, Dinis Pedro, Rajewsky, Klaus, Xiao, Changchun

“…The genomic region encoding the miR-17-92 microRNA (miRNA) cluster is often amplified in lymphoma and other cancers, and cancer cells carrying this…”
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Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis by Humphreys, Benjamin D, Xu, Fengfeng, Sabbisetti, Venkata, Grgic, Ivica, Movahedi Naini, Said, Wang, Ningning, Chen, Guochun, Xiao, Sheng, Patel, Dhruti, Henderson, Joel M, Ichimura, Takaharu, Mou, Shan, Soeung, Savuth, McMahon, Andrew P, Kuchroo, Vijay K, Bonventre, Joseph V

“…Acute kidney injury predisposes patients to the development of both chronic kidney disease and end-stage renal failure, but the molecular details underlying…”
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KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation by Brooks, Craig R, Yeung, Melissa Y, Brooks, Yang S, Chen, Hui, Ichimura, Takaharu, Henderson, Joel M, Bonventre, Joseph V

“…Phagocytosis of apoptotic cells by both professional and semi‐professional phagocytes is required for resolution of organ damage and maintenance of immune…”
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Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis by Pollak, Martin R, Brown, Elizabeth J, Schlöndorff, Johannes S, Becker, Daniel J, Tsukaguchi, Hiroyasu, Tonna, Stephen J, Uscinski, Andrea L, Higgs, Henry N, Henderson, Joel M

“…Martin Pollak and colleagues show that missense mutations in the diaphanous inhibitory domain of INF2 cause focal segmental glomerular sclerosis. INF2 encodes…”
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Segmentation of Glomeruli Within Trichrome Images Using Deep Learning by Kannan, Shruti, Morgan, Laura A, Liang, Benjamin, Cheung, McKenzie G, Lin, Christopher Q, Mun, Dan, Nader, Ralph G, Belghasem, Mostafa E, Henderson, Joel M, Francis, Jean M, Chitalia, Vipul C, Kolachalama, Vijaya B

“…The number of glomeruli and glomerulosclerosis evaluated on kidney biopsy slides constitute standard components of a renal pathology report. Prevailing methods…”
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Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy by Dunlap, Garrett S., DiToro, Daniel, Henderson, Joel, Shah, Sujal I., Manos, Mike, Severgnini, Mariano, Weins, Astrid, Guleria, Indira, Ott, Patrick A., Murakami, Naoka, Rao, Deepak A.

“…Kidney transplant recipients are at particular risk for developing tumors, many of which are now routinely treated with immune checkpoint inhibitors (ICIs);…”
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Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks by Kolachalama, Vijaya B., Singh, Priyamvada, Lin, Christopher Q., Mun, Dan, Belghasem, Mostafa E., Henderson, Joel M., Francis, Jean M., Salant, David J., Chitalia, Vipul C.

“…Chronic kidney damage is routinely assessed semiquantitatively by scoring the amount of fibrosis and tubular atrophy in a renal biopsy sample. Although image…”
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B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity by Pao, Lily I., Lam, Kong-Peng, Henderson, Joel M., Kutok, Jeffery L., Alimzhanov, Marat, Nitschke, Lars, Thomas, Matthew L., Neel, Benjamin G., Rajewsky, Klaus

“…Spontaneous loss-of-function mutations in the protein-tyrosine phosphatase Shp1 cause the motheaten phenotype, characterized by widespread inflammation and…”
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Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk by Shashar, Moshe, Belghasem, Mostafa E, Matsuura, Shinobu, Walker, Joshua, Richards, Sean, Alousi, Faisal, Rijal, Keshab, Kolachalama, Vijaya B, Balcells, Mercedes, Odagi, Minami, Nagasawa, Kazuo, Henderson, Joel M, Gautam, Amitabh, Rushmore, Richard, Francis, Jean, Kirchhofer, Daniel, Kolandaivelu, Kumaran, Sherr, David H, Edelman, Elazer R, Ravid, Katya, Chitalia, Vipul C

“…Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on…”
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Molecular Signatures of Glomerular Neovascularization in a Patient with Diabetic Kidney Disease by Ferkowicz, Michael J, Verma, Ashish, Barwinska, Daria, Melo Ferreira, Ricardo, Henderson, Joel M, Kirkpatrick, Mary, Silva, Paolo S, Steenkamp, Devin W, Phillips, Carrie L, Waikar, Sushrut S, Sutton, Timothy A

“…The Kidney Precision Medicine Project (KPMP) aims to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets…”
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Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure by Pisarek-Horowitz, Anna, Fan, Xueping, Kumar, Sudhir, Rasouly, Hila M., Sharma, Richa, Chen, Hui, Coser, Kathryn, Bluette, Crystal T., Hirenallur-Shanthappa, Dinesh, Anderson, Sarah R., Yang, Hongying, Beck, Laurence H., Bonegio, Ramon G., Henderson, Joel M., Berasi, Stephen P., Salant, David J., Lu, Weining

“…Roundabout guidance receptor 2 (ROBO2) plays an important role during early kidney development. ROBO2 is expressed in podocytes, inhibits nephrin-induced actin…”
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Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report by Al-Rabadi, Laith, Ayalon, Rivka, Bonegio, Ramon G., Ballard, Jennifer E., Fujii, Alan M., Henderson, Joel M., Salant, David J., Beck, Laurence H.

“…There is little information about pregnancy outcomes in patients with active membranous nephropathy (MN), especially those with circulating autoantibodies to…”
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TMIGD1 Is a Novel Adhesion Molecule That Protects Epithelial Cells from Oxidative Cell Injury by Arafa, Emad, Bondzie, Philip A, Rezazadeh, Kobra, Meyer, Rosana D, Hartsough, Edward, Henderson, Joel M, Schwartz, John H, Chitalia, Vipul, Rahimi, Nader

“…Oxidative damage to renal tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney injury and chronic kidney diseases…”
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Eculizumab Use in Scleroderma Renal Crisis With Thrombotic Microangiopathy: A Case Report by Trivin-Avillach, Claire, Jaberi, Aala, Henderson, Joel M, Beck, Jr, Laurence H, Francis, Jean

“…A Black woman in her 40s with past medical history significant for obesity treated with Roux-en-Y bypass surgery and a history of Raynaud's phenomenon,…”
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KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease by Mori, Yutaro, Ajay, Amrendra K., Chang, Jae-Hyung, Mou, Shan, Zhao, Huiping, Kishi, Seiji, Li, Jiahua, Brooks, Craig R., Xiao, Sheng, Woo, Heung-Myong, Sabbisetti, Venkata S., Palmer, Suetonia C., Galichon, Pierre, Li, Li, Henderson, Joel M., Kuchroo, Vijay K., Hawkins, Julie, Ichimura, Takaharu, Bonventre, Joseph V.

“…Tubulointerstitial abnormalities are predictive of the progression of diabetic kidney disease (DKD), and their targeting may be an effective means for…”
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The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis by Carrasco, Daniel R., Sukhdeo, Kumar, Protopopova, Marina, Sinha, Raktim, Enos, Miriam, Carrasco, Daniel E., Zheng, Mei, Mani, Mala, Henderson, Joel, Pinkus, Geraldine S., Munshi, Nikhil, Horner, James, Ivanova, Elena V., Protopopov, Alexei, Anderson, Kenneth C., Tonon, Giovanni, DePinho, Ronald A.

“…Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are…”
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Similar Biophysical Abnormalities in Glomeruli and Podocytes from Two Distinct Models by Embry, Addie E, Liu, Zhenan, Henderson, Joel M, Byfield, F Jefferson, Liu, Liping, Yoon, Joonho, Wu, Zhenzhen, Cruz, Katrina, Moradi, Sara, Gillombardo, C Barton, Hussain, Rihanna Z, Doelger, Richard, Stuve, Olaf, Chang, Audrey N, Janmey, Paul A, Bruggeman, Leslie A, Miller, R Tyler

“…FSGS is a pattern of podocyte injury that leads to loss of glomerular function. Podocytes support other podocytes and glomerular capillary structure, oppose…”
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Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts by Menn-Josephy, Hanni, Lee, Carol S, Nolin, Angela, Christov, Marta, Rybin, Denis V, Weinberg, Janice M, Henderson, Joel, Bonegio, Ramon, Havasi, Andrea

“…The extent of interstitial fibrosis on kidney biopsy is regarded as a prognostic indicator and guide to treatment. Patients with extensive fibrosis are…”
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