Search Results - "Henderson, Graeme B"

Purification and characterization of dihydroorotate dehydrogenase from the rodent malaria parasite Plasmodium berghei by Krungkrai, Jerapan, Cerami, Anthony, Henderson, Graeme B

“…Dihydroorotate dehydrogenase (DHODase) has been purified 400-fold from the rodent malaria parasite Plasmodium berghei to apparent homogeneity by Triton X-100…”
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Pyrimidine biosynthesis in parasitic protozoa: purification of a monofunctional dihydroorotase from Plasmodium berghei and Crithidia fasciculata by Krungkrai, Jerapan, Cerami, Anthony, Henderson, Graeme B

“…Dihydroorotase (DHOase) catalyzes the reversible cyclization of N-carbamoyl-L-aspartate (L-CA) to L-5,6-dihydroorotate (L-DHO), which is the third enzyme in de…”
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Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata by Henderson, Graeme B, Fairlamb, Alan H, Ulrich, Peter, Cerami, Anthony

“…The substrate specificity of the trypanosomatid enzyme trypanothione reductase has been studied by measuring the ability of the enzyme to reduce a series of…”
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Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata by Henderson, Graeme B, Yamaguchi, Miyuki, Novoa, Louis, Fairlamb, Alan H, Cerami, Anthony

“…Trypanothione synthetase from Crithidia fasciculata has been purified ca. 14,500-fold to homogeneity in an overall yield of 40%. The pure enzyme catalyzed the…”
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An Iron-Carboxylate Bond Links the Heme Units of Malaria Pigment by Andrew F. G. Slater, Swiggard, William J., Orton, Brian R., Flitter, William D., Goldberg, Daniel E., Cerami, Anthony, Henderson, Graeme B.

“…The intraerythrocytic malaria parasite uses hemoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an…”
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Hemoglobin Degradation in the Malaria Parasite Plasmodium falciparum: An Ordered Process in a Unique Organelle by Goldberg, Daniel E., Andrew F. G. Slater, Cerami, Anthony, Henderson, Graeme B.

“…The malaria parasite Plasmodium falciparum uses host erythrocyte hemoglobin as a major nutrient source. We report the purification of P. falciparum digestive…”
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Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum : a catabolic pathway initiated by a specific aspartic protease by GOLDBERG, D. E, SLATER, A. F. G, BEAVIS, R, CHAIT, B, CERAMI, A, HENDERSON, G. B

“…Hemoglobin is an important nutrient source for intraerythrocytic malaria organisms. Its catabolism occurs in an acidic digestive vacuole. Our previous studies…”
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Trypanothione is the Primary Target for Arsenical Drugs against African Trypanosomes by Fairlamb, Alan H., Henderson, Graeme B., Cerami, Anthony

“…The trypanosomatid metabolite N1, N8-bis-(glutathionyl)spermidine (trypanothione) has been demonstrated to form a stable adduct with the aromatic arsenical…”
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X-Ray Structure of Trypanothione Reductase from Crithidia fasciculata at 2.4-Å Resolution by Kuriyan, John, Kong, Xiang-Peng, Krishna, T. S. R., Sweet, Robert M., Murgolo, Nicholas J., Field, Helen, Cerami, Anthony, Henderson, Graeme B.

“…Trypanosomes and related protozoan parasites lack glutathione reductase and possess instead a closely related enzyme that serves as the reductant of a…”
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Subversive'' Substrates for the Enzyme Trypanothione Disulfide Reductase: Alternative Approach to Chemotherapy of Chagas Disease by Henderson, Graeme B., Ulrich, Peter, Fairlamb, Alan H., Rosenberg, Ian, Pereira, Miercio, Sela, Michael, Cerami, Anthony

“…The trypanosomatid flavoprotein disulfide reductase, trypanothione reductase, is shown to catalyze one-electron reduction of suitably substituted…”
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In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei by Fairlamb, A H, Henderson, G B, Bacchi, C J, Cerami, A

“…The effect of D,L-alpha-difluoromethylornithine (DFMO) on thiol and polyamine levels in Trypanosoma brucei was investigated by isolating trypanosomes from…”
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Engineering the Substrate Specificity of Glutathione Reductase Toward that of Trypanothione Reduction by Henderson, Graeme B., Murgolo, Nicholas J., Kuriyan, John, Osapay, Klara, Kominos, Dorothea, Berry, Alan, Scrutton, Nigel S., Hinchliffe, Nigel W., Perham, Richard N., Cerami, Anthony

“…Glutathione reductase (EC 1.6.4.2; CAS registry number 9001-48-3) and trypanothione reductase (CAS registry number 102210-35-5), which are related flavoprotein…”
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Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei by Henderson, G B, Fairlamb, A H, Cerami, A

“…A trypanothione-dependent peroxidase activity has been identified in the insect trypanosomatid Crithidia fasciculata and in the mammalian trypanosome…”
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Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei by Bellofatto, V, Fairlamb, A H, Henderson, G B, Cross, G A

“…Procyclic Trypanosoma brucei grown in semi-defined media are sensitive to alpha-difluoromethylornithine (DFMO) (EC50 100 microM), an inhibitor of ornithine…”
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The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata by Fairlamb, A H, Henderson, G B, Cerami, A

“…Studies on the biosynthesis of trypanothione [N1,N8-bis(glutathionyl)-spermidine] in the insect trypanosomatid Crithidia fasciculata have led to the discovery…”
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Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme by Krauth-Siegel, R L, Enders, B, Henderson, G B, Fairlamb, A H, Schirmer, R H

“…The structural differences between trypanothione reductase of Trypanosoma cruzi and human glutathione reductase, an enzyme of known three-dimensional…”
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Preliminary crystallographic analysis of trypanothione reductase from Crithidia fasciculata by Kuriyan, J, Wong, L, Guenther, B D, Murgolo, N J, Cerami, A, Henderson, G B

“…Trypanothione reductase, a flavoprotein disulfide reductase specific to trypanosomatid parasites, has been crystallized by vapor diffusion of a protein…”
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Trypanothione reductase from Trypanosoma cruzi by KRAUTH‐SIEGEL, R. Luise, ENDERS, Burkhard, HENDERSON, Graeme B., FAIRLAMB, Alan H., SCHIRMER, R. Heiner

“…The structural differences between trypanothione reductase of Trypanosoma cruzi and human glutathione reductase, an enzyme of known three‐dimensional…”
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