Search Results - "Henderson, Desmond"
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Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene
Published in Experimental neurology (01-12-2019)“…Visual deficits after traumatic brain injury (TBI) are common, but interventions that limit the post-trauma impairments have not been identified. We have found…”
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Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury
Published in Frontiers in neuroscience (29-10-2021)“…Mild traumatic brain injury (TBI) involves widespread axonal injury and activation of microglia, which initiates secondary processes that worsen the TBI…”
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Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast
Published in Experimental eye research (01-05-2022)“…Visual deficits after ocular blast injury (OBI) are common, but pharmacological approaches to improve long-term outcomes have not been identified. Blast forces…”
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Diabetes Alters pH Control in Rat Retina
Published in Investigative ophthalmology & visual science (01-02-2019)“…The purpose of this study was to determine whether the ability of the rat retina to control its pH is affected by diabetes. Double-barreled H+-selective…”
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Development of diabetes-induced acidosis in the rat retina
Published in Experimental eye research (01-08-2016)“…We hypothesized that the retina of diabetic animals would be unusually acidic due to increased glycolytic metabolism. Acidosis in tumors and isolated retina…”
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Light-induced pH changes in the intact retinae of normal and early diabetic rats
Published in Experimental eye research (01-04-2016)“…Double-barreled H+-selective microelectrodes were used to measure local extracellular concentration of H+ ([H+]o) in the retina of dark-adapted anesthetized…”
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Retinal pH and Acid Regulation During Metabolic Acidosis
Published in Current eye research (03-07-2018)“…Purpose: Changes in retinal pH may contribute to a variety of eye diseases. To study the effect of acidosis alone, we induced systemic metabolic acidosis and…”
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