Search Results - "Henderson, Deborah J"

Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets by Phillips, Helen M, Mahendran, Pavithra, Singh, Esha, Anderson, Robert H, Chaudhry, Bill, Henderson, Deborah J

“…Anomalies of the arterial valves, principally bicuspid aortic valve (BAV), are the most common congenital anomalies. The cellular mechanisms that underlie…”
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eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling by Eley, Lorraine, Richardson, Rachel V, Alqahtani, Ahlam, Chaudhry, Bill, Henderson, Deborah J

“…eNOS (NOS3) is the enzyme that generates nitric oxide, a signalling molecule and regulator of vascular tone. Loss of eNOS function is associated with increased…”
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Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression by Santos-Ledo, Adrian, Washer, Sam, Dhanaseelan, Tamil, Eley, Lorraine, Alqatani, Ahlam, Chrystal, Paul W, Papoutsi, Tania, Henderson, Deborah J, Chaudhry, Bill

“…The planar cell polarity pathway is required for heart development and whilst the functions of most pathway members are known, the roles of the jnk genes in…”
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Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves by Queen, Rachel, Crosier, Moira, Eley, Lorraine, Kerwin, Janet, Turner, Jasmin E, Yu, Jianshi, Alqahtani, Ahlam, Dhanaseelan, Tamilvendhan, Overman, Lynne, Soetjoadi, Hannah, Baldock, Richard, Coxhead, Jonathan, Boczonadi, Veronika, Laude, Alex, Cockell, Simon J, Kane, Maureen A, Lisgo, Steven, Henderson, Deborah J

“…Abnormalities of the arterial valves, including bicuspid aortic valve (BAV) are amongst the most common congenital defects and are a significant cause of…”
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Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development by Ramsbottom, Simon A, Sharma, Vipul, Rhee, Hong Jun, Eley, Lorraine, Phillips, Helen M, Rigby, Hannah F, Dean, Charlotte, Chaudhry, Bill, Henderson, Deborah J

“…Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated…”
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New Concepts in the Development and Malformation of the Arterial Valves by Henderson, Deborah J, Eley, Lorraine, Chaudhry, Bill

“…Although in many ways the arterial and atrioventricular valves are similar, both being derived for the most part from endocardial cushions, we now know that…”
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Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish by Murphy, Lindsay B, Santos-Ledo, Adrian, Dhanaseelan, Tamilvendhan, Eley, Lorraine, Burns, David, Henderson, Deborah J, Chaudhry, Bill

“…Exercise may ameliorate the eventual heart failure inherent in human aging. In this study, we use zebrafish to understand how aging and exercise affect…”
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Normal and abnormal development of the intrapericardial arterial trunks in humans and mice by ANDERSON, Robert H, CHAUDHRY, Bill, MOHUN, Timothy J, BAMFORTH, Simon D, HOYLAND, Darren, PHILLIPS, Helen M, WEBB, Sandra, MOORMAN, Antoon F. M, BROWN, Nigel A, HENDERSON, Deborah J

“…The definitive cardiac outflow channels have three components: the intrapericardial arterial trunks; the arterial roots with valves; and the ventricular…”
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Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos by Galea, Gabriel L, Nychyk, Oleksandr, Mole, Matteo A, Moulding, Dale, Savery, Dawn, Nikolopoulou, Evanthia, Henderson, Deborah J, Greene, Nicholas D E, Copp, Andrew J

“…Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice…”
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Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth by Dos-Santos Carvalho, Steve, Moreau, Maite M, Hien, Yeri Esther, Garcia, Mikael, Aubailly, Nathalie, Henderson, Deborah J, Studer, Vincent, Sans, Nathalie, Thoumine, Olivier, Montcouquiol, Mireille

“…Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are essential for axon outgrowth and guidance. Whether planar cell polarity…”
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A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice by Eley, Lorriane, Alqahtani, Ahlam Ms, MacGrogan, Donal, Richardson, Rachel V, Murphy, Lindsay, Salguero-Jimenez, Alejandro, Sintes Rodriguez San Pedro, Marcos, Tiurma, Shindi, McCutcheon, Lauren, Gilmore, Adam, de La Pompa, José Luis, Chaudhry, Bill, Henderson, Deborah J

“…Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have…”
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Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve by Henderson, Deborah J, Eley, Lorraine, Turner, Jasmin E, Chaudhry, Bill

“…Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the…”
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The Left Ventricular Myocardium in Hypoplastic Left Heart Syndrome by Chaudhry, Bill, Alqahtani, Ahlam, Eley, Lorraine, Coats, Louise, Moldovan, Corina, Annavarapu, Srinivas R., Henderson, Deborah J.

“…Hypoplastic left heart syndrome (HLHS) is a collective term applied to severe congenital cardiac malformations, characterised by a combination of abnormalities…”
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The Editors' Personal Biography of Professor Robert Anderson by Brown, Nigel A, Henderson, Deborah J

“…Robert (Bob) Henry Anderson was born in Wellington, Shropshire, UK, in 1942 and he completed his medical training in Manchester (UK) in 1966 [...]…”
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Neural crest cell survival is dependent on Rho kinase and is required for development of the mid face in mouse embryos by Phillips, Helen M, Papoutsi, Tania, Soenen, Helena, Ybot-Gonzalez, Patricia, Henderson, Deborah J, Chaudhry, Bill

“…Neural crest cells (NCC) give rise to much of the tissue that forms the vertebrate head and face, including cartilage and bone, cranial ganglia and teeth. In…”
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Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse by Curtin, John A., Quint, Elizabeth, Tsipouri, Vicky, Arkell, Ruth M., Cattanach, Bruce, Copp, Andrew J., Henderson, Deborah J., Spurr, Nigel, Stanier, Philip, Fisher, Elizabeth M., Nolan, Patrick M., Steel, Karen P., Brown, Steve D.M., Gray, Ian C., Murdoch, Jennifer N.

“…We identified two novel mouse mutants with abnormal head-shaking behavior and neural tube defects during the course of independent ENU mutagenesis experiments…”
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Disruption of Planar Cell Polarity Signaling Results in Congenital Heart Defects and Cardiomyopathy Attributable to Early Cardiomyocyte Disorganization by Phillips, Helen M, Rhee, Hong Jun, Murdoch, Jennifer N, Hildreth, Victoria, Peat, Jonathan D, Anderson, Robert H, Copp, Andrew J, Chaudhry, Bill, Henderson, Deborah J

“…The Drosophila scribble gene regulates apical-basal polarity and is implicated in control of cellular architecture and cell growth control. Mutations in…”
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Autonomic innervation of the developing heart: Origins and function by Hildreth, Victoria, Anderson, Robert H., Henderson, Deborah J.

“…Maintenance of homeostatic circulation in mammals and birds is reliant upon autonomic innervation of the heart. Neural branches of mixed cellular origin and…”
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Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development by Stothard, Catherine A, Mazzotta, Silvia, Vyas, Arjun, Schneider, Jurgen E, Mohun, Timothy J, Henderson, Deborah J, Phillips, Helen M, Bamforth, Simon D

“…The correct formation of the aortic arch arteries depends on a coordinated and regulated gene expression profile within the tissues of the pharyngeal arches…”
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Foregut separation and tracheo-oesophageal malformations: The role of tracheal outgrowth, dorso-ventral patterning and programmed cell death by Ioannides, Adonis S., Massa, Valentina, Ferraro, Elisabetta, Cecconi, Francesco, Spitz, Lewis, Henderson, Deborah J., Copp, Andrew J.

“…Foregut division—the separation of dorsal (oesophageal) from ventral (tracheal) foregut components—is a crucial event in gastro-respiratory development, and…”
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