Generation of four induced pluripotent stem cells lines from PBMC of the DFNA58 family members: Two hearing-impaired duplication carriers (USPi006-A e USPi007-A) and two normal-hearing noncarriers (USPi004-A and USPi005-A)

Generation of four induced pluripotent stem cells lines from PBMC of the DFNA58 family members: Two hearing-impaired duplication carriers (USPi006-A e USPi007-A) and two normal-hearing noncarriers (USPi004-A and USPi005-A)

The DFNA58 locus contains a genomic duplication involving three protein-coding genes (CNRIP1, PLEK, and PPP3R1′s exon 1) and other uncharacterized lncRNA genes (LOC101927723, LOC107985892 and LOC102724389). To clarify the role of these genes in hearing and precisely determine their role in hearing l...

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Bibliographic Details
Published in:Stem cell research Vol. 71; p. 103181
Main Authors: Kobayashi, Gerson S., Vieira-Silva, Gleiciele A., Varella-Branco, Elisa, Moreira, Danielle P., Kitajima, João Paulo F.W., Hemza, Claudia R.M.L., Mingroni-Netto, Regina C., Lojudice, Fernando H., Oiticica, Jeanne, Bento, Ricardo F., Batissoco, Ana C., Lezirovitz, Karina
Format: Journal Article
Language:English
Published: Elsevier 01-09-2023
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Summary:The DFNA58 locus contains a genomic duplication involving three protein-coding genes (CNRIP1, PLEK, and PPP3R1′s exon 1) and other uncharacterized lncRNA genes (LOC101927723, LOC107985892 and LOC102724389). To clarify the role of these genes in hearing and precisely determine their role in hearing loss, four iPSC lines were generated from two carriers and two noncarriers of the duplication.
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ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2023.103181