Revisiting the Role of Neutralizing Antibodies in Mother-to-Child Transmission of HIV-1

We analyzed the association between mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) and maternal neutralizing antibodies to heterologous primary isolates of various HIV-1 clades, to test the hypothesis that protective antibodies are those with broad neutralizing ac...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 193; no. 11; pp. 1504 - 1511
Main Authors:	Barin, Francis, Jourdain, Gonzague, Brunet, Sylvie, Ngo-Giang-Huong, Nicole, Weerawatgoompa, Supawadee, Karnchanamayul, Warit, Ariyadej, Surabhon, Hansudewechakul, Rawiwan, Achalapong, Jullapong, Yuthavisuthi, Prapap, Ngampiyaskul, Chaiwat, Bhakeecheep, Sorakij, Hemwutthiphan, Chittaphon, Lallemant, Marc
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 01-06-2006 University of Chicago Press Oxford University Press
Subjects:	AIDS Antibodies Biological and medical sciences Disease transmission Disease Transmission, Infectious Female Fundamental and applied biological sciences. Psychology HIV HIV 1 HIV Antibodies - blood HIV Antibodies - immunology HIV Infections - immunology HIV Infections - transmission HIV-1 - immunology HIV/AIDS Human immunodeficiency virus 1 Humans Infant, Newborn Infections Infectious diseases Logistic Models Logistic regression Medical sciences Microbiology Miscellaneous Mothers Neutralization Tests Neutralizing antibodies Pregnancy Pregnancy Complications, Infectious - immunology Statistics as Topic Viral load Virology Viruses Virus Infection Microbiology HIV-1 virus Retroviridae Vertical transmission Human immunodeficiency virus Lentivirus Neutralizing antibody
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Summary:	We analyzed the association between mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) and maternal neutralizing antibodies to heterologous primary isolates of various HIV-1 clades, to test the hypothesis that protective antibodies are those with broad neutralizing activity. Our study sample included 90 Thai women for whom the timing of HIV-1 transmission (in utero or intrapartum) was known. The statistical analysis included a conditional logistic-regression model to control for both plasma viral load and duration of zidovudine prophylaxis. The higher the titer of neutralizing antibodies to a heterologous strain of the same clade, the lower the rate of MTCT of HIV-1. More specifically, high levels of neutralizing antibodies to the MBA (CRF01_AE) strain were associated with low intrapartum transmission of HIV-1. This suggested that such heterologous neutralizing antibodies may be involved in the natural prevention of late perinatal HIV transmission. These data are consistent with the hypothesis that the use of some antibodies might help to prevent perinatal HIV transmission, through passive immunoprophylaxis. Moreover, the study of humoral factors associated with MTCT of HIV-1 may identify correlates of protection that should help in the design of efficient HIV/acquired immunodeficiency syndrome vaccines
Bibliography:	ark:/67375/HXZ-QRWRGVVQ-9 istex:C62E2296210CF69DFF0BEF9B742508EBDA45E5C7 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1899 1537-6613
DOI:	10.1086/503778