Search Results - "Hemsley, M."

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease? by Whyte, Lauren S., Lau, Adeline A., Hemsley, Kim M., Hopwood, John J., Sargeant, Timothy J.

“…Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will increase significantly in the coming decades. Although important…”
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The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation by Butt, Aaron, Higman, Victoria A, Williams, Christopher, Crump, Matthew P, Hemsley, Claudia M, Harmer, Nicholas, Titball, Richard W

“…TA (toxin-antitoxin) systems are widely distributed amongst bacteria and are associated with the formation of antibiotic tolerant (persister) cells that may…”
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Extensive genome analysis of Coxiella burnetii reveals limited evolution within genomic groups by Hemsley, Claudia M, O'Neill, Paul A, Essex-Lopresti, Angela, Norville, Isobel H, Atkins, Tim P, Titball, Richard W

“…Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. An…”
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Burkholderia thailandensis strain E555 is a surrogate for the investigation of Burkholderia pseudomallei replication and survival in macrophages by Kovacs-Simon, A, Hemsley, C M, Scott, A E, Prior, J L, Titball, R W

“…Burkholderia pseudomallei is a human pathogen causing severe infections in tropical and subtropical regions and is classified as a bio-threat agent. B…”
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A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome by Winner, Leanne K, Beard, Helen, Hassiotis, Sofia, Lau, Adeline A, Luck, Amanda J, Hopwood, John J, Hemsley, Kim M

“…Mucopolysaccharidosis type IIIA (MPS IIIA) is predominantly a disorder of the central nervous system, caused by a deficiency of sulfamidase (SGSH) with…”
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Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment by Bhattacharjee, Rudrarup, Jolly, Lachlan A., Corbett, Mark A., Wee, Ing Chee, Rao, Sushma R., Gardner, Alison E., Ritchie, Tarin, van Hugte, Eline J. H., Ciptasari, Ummi, Piltz, Sandra, Noll, Jacqueline E., Nazri, Nazzmer, van Eyk, Clare L., White, Melissa, Fornarino, Dani, Poulton, Cathryn, Baynam, Gareth, Collins-Praino, Lyndsey E., Snel, Marten F., Nadif Kasri, Nael, Hemsley, Kim M., Thomas, Paul Q., Kumar, Raman, Gecz, Jozef

“…We implicated the X-chromosome THOC2 gene, which encodes the largest subunit of the highly-conserved TREX ( Tr anscription- Ex port) complex, in a clinically…”
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Correlating Genotyping Data of Coxiella burnetii with Genomic Groups by Hemsley, Claudia M., Essex-Lopresti, Angela, Norville, Isobel H., Titball, Richard W.

“…Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans…”
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Progress in antischistosomal N,N′-diaryl urea SAR by Wu, Jianbo, Wang, Chunkai, Leas, Derek, Vargas, Mireille, White, Karen L., Shackleford, David M., Chen, Gong, Sanford, Austin G., Hemsley, Ryan M., Davis, Paul H., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.

“…[Display omitted] •Expansion of antischistosomal N,N′-diaryl urea SAR.•3-Trifluoromethyl-4-pyridyl and 2,2-difluorobenzodioxole improve…”
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Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development by Moule, Madeleine G, Hemsley, Claudia M, Seet, Qihui, Guerra-Assunção, José Afonso, Lim, Jiali, Sarkar-Tyson, Mitali, Clark, Taane G, Tan, Patrick B O, Titball, Richard W, Cuccui, Jon, Wren, Brendan W

“…Burkholderia pseudomallei is the causative agent of melioidosis, an often fatal infectious disease for which there is no vaccine. B. pseudomallei is listed as…”
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Identification of Burkholderia pseudomallei Genes Induced During Infection of Macrophages by Differential Fluorescence Induction by Jitprasutwit, Siroj, Jitprasutwit, Niramol, Hemsley, Claudia M, Onlamoon, Nattawat, Withatanung, Patoo, Muangsombut, Veerachat, Vattanaviboon, Paiboon, Stevens, Joanne M, Ong, Catherine, Stevens, Mark P, Titball, Richard W, Korbsrisate, Sunee

“…, the causative agent of melioidosis, can survive and replicate in macrophages. Little is known about genes that are induced during macrophage infection. We…”
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AAVrh10 Vector Corrects Disease Pathology in MPS IIIA Mice and Achieves Widespread Distribution of SGSH in Large Animal Brains by Hocquemiller, Michaël, Hemsley, Kim M., Douglass, Meghan L., Tamang, Sarah J., Neumann, Daniel, King, Barbara M., Beard, Helen, Trim, Paul J., Winner, Leanne K., Lau, Adeline A., Snel, Marten F., Gomila, Cathy, Ausseil, Jérôme, Mei, Xin, Giersch, Laura, Plavsic, Mark, Laufer, Ralph

“…Patients with mucopolysaccharidosis type IIIA (MPS IIIA) lack the lysosomal enzyme sulfamidase (SGSH), which is responsible for the degradation of heparan…”
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Determination of the role of injection site on the efficacy of intra-CSF enzyme replacement therapy in MPS IIIA mice by Beard, Helen, Luck, Amanda J., Hassiotis, Sofia, King, Barbara, Trim, Paul J., Snel, Marten F., Hopwood, John J., Hemsley, Kim M.

“…MPS IIIA is an inherited neurodegenerative lysosomal storage disorder characterized by cognitive impairment, sleep–wake cycle disturbance, speech difficulties,…”
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Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease by Whyte, Lauren S., Hemsley, Kim M., Lau, Adeline A., Hassiotis, Sofia, Saito, Takashi, Saido, Takaomi C., Hopwood, John J., Sargeant, Timothy J.

“…•AppNL−G−F mice show reduced open field activity at six months of age.•Detection of memory deficits in six month AppNL−G−F mice may depend on…”
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Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice by Lau, Adeline A., Crawley, Allison C., Hopwood, John J., Hemsley, Kim M.

“…Mucopolysaccharidosis (MPS) IIIA, or Sanfilippo syndrome, is a lysosomal storage disorder characterized by severe and progressive neuropathology. Following an…”
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Enzyme replacement reduces neuropathology in MPS IIIA dogs by Crawley, Allison C, Marshall, Neil, Beard, Helen, Hassiotis, Sofia, Walsh, Vicki, King, Barbara, Hucker, Nicola, Fuller, Maria, Jolly, Robert D, Hopwood, John J, Hemsley, Kim M

“…Abstract There is no treatment for the progressive neurodegenerative lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA), which occurs due to…”
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Is the eye a window to the brain in Sanfilippo syndrome? by Beard, Helen, Chidlow, Glyn, Neumann, Daniel, Nazri, Nazzmer, Douglass, Meghan, Trim, Paul J, Snel, Marten F, Casson, Robert J, Hemsley, Kim M

“…Sanfilippo syndrome is an untreatable form of childhood-onset dementia. Whilst several therapeutic strategies are being evaluated in human clinical trials…”
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Examination of intravenous and intra-CSF protein delivery for treatment of neurological disease by Hemsley, Kim M., Luck, Amanda J., Crawley, Allison C., Hassiotis, Sofia, Beard, Helen, King, Barbara, Rozek, Tomas, Rozaklis, Tina, Fuller, Maria, Hopwood, John J.

“…Mucopolysaccharidosis type IIIA is a neurodegenerative lysosomal storage disorder characterized by progressive loss of learned skills, sleep disturbance and…”
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Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer’s disease by Whyte, Lauren S., Fourrier, Célia, Hassiotis, Sofia, Lau, Adeline A., Trim, Paul J., Hein, Leanne K., Hattersley, Kathryn J., Bensalem, Julien, Hopwood, John J., Hemsley, Kim M., Sargeant, Timothy J.

“…Lysosomal network abnormalities are an increasingly recognised feature of Alzheimer’s disease (AD), which appear early and are progressive in nature. Sandhoff…”
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Evaluating the relationship between acidogenicity and acid tolerance for oral streptococci from children with or without a history of caries by Banas, Jeffrey A., Takanami, Erika, Hemsley, Ryan M., Villhauer, Alissa, Zhu, Min, Qian, Fang, Marolf, Amber, Drake, David R.

“…Background: Dental caries etiology is attributed to a dysbiotic imbalance within the plaque microbiome leading to a dominance of strong acidogens. Some studies…”
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A lower motor neuron disease in takahē (Porphyrio hochstetteri) is an endoplasmic reticulum storage disease by Jolly, RD, Perrott, MR, Alley, MR, Hunter, SA, Pas, A, Beard, H, Hemsley, KM, Greaves, G

“…To investigate the pathogenesis of a disease in takahē (Porphyrio hochstetteri) with intracytoplasmic inclusion bodies in lower motor neurons. Four birds aged…”
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