Search Results - "Hempshall, Aiden"

Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients by Gillespie, Justin, Savic, Sinisa, Wong, Chi, Hempshall, Aiden, Inman, Martyn, Emery, Paul, Grigg, Ronald, McDermott, Michael F.

“…Objective To characterize the role of histone deacetylase (HDAC) activity in rheumatoid arthritis (RA) and to evaluate the effects of MI192, a novel…”
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The effect of epigenetic reprogramming using MI192 HDAC inhibitor on enhancing the osteogenesis of human adipose-derived stem cells in vitro by Lu, Wei, Ji, Kun, Lawlor, Liam, Saha, Sushmita, Hempshall, Aiden, Jin, Yan, Yang, Xuebin B

“…The ability to control stem cell function is the key to stem cell-based therapy and living tissue regeneration. In natural conditions, histone deacetylases…”
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γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5-component cascades by Dondas, H. Ali, Hempshall, Aiden, Narramore, Sarah, Kilner, Colin, Fishwick, Colin W.G., Grigg, Ronald

“…γ-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component…”
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Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192 by Boissinot, Marjorie, Inman, Martyn, Hempshall, Aiden, James, Sally R, Gill, Jason H, Selby, Peter, Bowen, David T, Grigg, Ronald, Cockerill, Peter N

“…Abstract Histone deacetylase inhibitors (HDACIs) are in advanced clinical development as cancer therapeutic agents. However, first generation HDACIs such as…”
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