Search Results - "Hemphill, Linda C."

Nonpharmacological Lipoprotein Apheresis Reduces Arterial Inflammation in Familial Hypercholesterolemia by van Wijk, Diederik F., MD, Sjouke, Barbara, MD, Figueroa, Amparo, MD, Emami, Hamed, MD, van der Valk, Fleur M., MD, MacNabb, Megan H., BA, Hemphill, Linda C., MD, Schulte, Dominik M., MD, PhD, Koopman, Marion G., MD, PhD, Lobatto, Mark E., MD, Verberne, Hein J., MD, PhD, Fayad, Zahi A., MD, PhD, Kastelein, John J.P., MD, PhD, Mulder, Willem J.M., PhD, Hovingh, G. Kees, MD, PhD, Tawakol, Ahmed, MD, Stroes, Erik S.G., MD, PhD

“…Abstract Background Patients with familial hypercholesterolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-density…”
Get full text

Cardiovascular disease risk prediction by the American College of Cardiology (ACC)/American Heart Association (AHA) Atherosclerotic Cardiovascular Disease (ASCVD) risk score among HIV-infected patients in sub-Saharan Africa by Mosepele, Mosepele, Hemphill, Linda C, Palai, Tommy, Nkele, Isaac, Bennett, Kara, Lockman, Shahin, Triant, Virginia A

“…HIV-infected patients are at increased risk for cardiovascular disease (CVD). However, general population CVD risk prediction equations that identify…”
Get full text

Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry by O’Brien, Emily C., PhD, Roe, Matthew T., MD, MHS, Fraulo, Elizabeth S., BSN, Peterson, Eric D., MD, MPH, Ballantyne, Christie M., MD, Genest, Jacques, MD, Gidding, Samuel S., MD, Hammond, Emma, BSc, PhD, Hemphill, Linda C., MD, Hudgins, Lisa C., MD, Kindt, Iris, MD, MPH, Moriarty, Patrick M., MD, Ross, Joyce, MSN, CRNP, Underberg, James A., MD, Watson, Karol, MD, Pickhardt, Dave, MBA, Rader, Daniel J., MD, Wilemon, Katherine, BS, Knowles, Joshua W., MD, PhD

“…Background Familial hypercholesterolemia (FH) is a hereditary condition caused by various genetic mutations that lead to significantly elevated low-density…”
Get full text

Pre-clinical carotid atherosclerosis and sCD163 among virally suppressed HIV patients in Botswana compared with uninfected controls by Mosepele, Mosepele, Hemphill, Linda C, Moloi, Walter, Moyo, Sikhulile, Nkele, Isaac, Makhema, Joseph, Bennett, Kara, Triant, Virginia A, Lockman, Shahin

“…Human immune deficiency virus (HIV) is associated with increased cardiovascular disease (CVD) risk, yet the relationship between HIV and carotid…”
Get full text

Contemporary Homozygous Familial Hypercholesterolemia in the United States: Insights From the CASCADE FH Registry by Cuchel, Marina, Lee, Paul C, Hudgins, Lisa C, Duell, P Barton, Ahmad, Zahid, Baum, Seth J, Linton, MacRae F, de Ferranti, Sarah D, Ballantyne, Christie M, Larry, John A, Hemphill, Linda C, Kindt, Iris, Gidding, Samuel S, Martin, Seth S, Moriarty, Patrick M, Thompson, Paul P, Underberg, James A, Guyton, John R, Andersen, Rolf L, Whellan, David J, Benuck, Irwin, Kane, John P, Myers, Kelly, Howard, William, Staszak, David, Jamison, Allison, Card, Mary C, Bourbon, Mafalda, Chora, Joana R, Rader, Daniel J, Knowles, Joshua W, Wilemon, Katherine, McGowan, Mary P

“…Background Homozygous familial hypercholesterolemia (HoFH) is a rare, treatment-resistant disorder characterized by early-onset atherosclerotic and aortic…”
Get full text

HIV disease is associated with increased biomarkers of endothelial dysfunction despite viral suppression on long-term antiretroviral therapy in Botswana by Lockman, Shahin, Mupfumi, Lucy, Moyo, Sikhulile, Hemphill, Linda C., Mosepele, Mosepele, Bennett, Kara, Triant, Virginia A., Mohammed, Terence

“…Background: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial…”
Get full text

Correlates of physical activity among people living with and without HIV in rural Uganda by Mabweazara, Smart Z, Manne-Goehler, Jennifer, Bibangambah, Prossy, Kim, June-Ho, Ruth, Sentongo, Hemphill, Linda C, Okello, Samson, Hamer, Mark, Siedner, Mark J

“…Antiretroviral therapy (ART) has led to diminishing AIDS-related mortality but a concomitant increase in non-communicable diseases (NCDs) for people with HIV…”
Get full text

Prevalence and correlates of carotid plaque in a mixed HIV-serostatus cohort in Uganda by Bibangambah, Prossy, Hemphill, Linda C, Acan, Moses, Tsai, Alexander C, Sentongo, Ruth N, Kim, June-Ho, Yang, Isabelle T, Siedner, Mark J, Okello, Samson

“…The extent to which the risk of atherosclerotic cardiovascular disease (ACVD) is increased among people living with HIV (PLWH) in sub-Saharan Africa remains…”
Get full text

Lung function and atherosclerosis: a cross-sectional study of multimorbidity in rural Uganda by Gilbert, Rebecca F, Cichowitz, Cody, Bibangambah, Prossy, Kim, June-Ho, Hemphill, Linda C, Yang, Isabelle T, Sentongo, Ruth N, Kakuhikire, Bernard, Christiani, David C, Tsai, Alexander C, Okello, Samson, Siedner, Mark J, North, Crystal M

“…Chronic obstructive pulmonary disease (COPD) is a leading cause of global mortality. In high-income settings, the presence of cardiovascular disease among…”
Get full text

Treated HIV Infection and Progression of Carotid Atherosclerosis in Rural Uganda: A Prospective Observational Cohort Study by Siedner, Mark J, Bibangambah, Prossy, Kim, June-Ho, Lankowski, Alexander, Chang, Jonathan L, Yang, Isabelle T, Kwon, Douglas S, North, Crystal M, Triant, Virginia A, Longenecker, Christopher, Ghoshhajra, Brian, Peck, Robert N, Sentongo, Ruth N, Gilbert, Rebecca, Kakuhikire, Bernard, Boum, 2nd, Yap, Haberer, Jessica E, Martin, Jeffrey N, Tracy, Russell, Hunt, Peter W, Bangsberg, David R, Tsai, Alexander C, Hemphill, Linda C, Okello, Samson

“…Background Although ≈70% of the world's population of people living with HIV reside in sub-Saharan Africa, there are minimal prospective data on the…”
Get full text

US Physician Practices for Diagnosing Familial Hypercholesterolemia: Data from the CASCADE- FH Registry by Ahmad, Zahid S., MD, Andersen, Rolf L., MD, Andersen, Lars H., BA, O’Brien, Emily C., PhD, Kindt, Iris, MD, MPH, Shrader, Peter, MA, Vasandani, Chandna, PhD, Newman, Connie B., MD, deGoma, Emil M., MD, Baum, Seth J., MD, Hemphill, Linda C., MD, Hudgins, Lisa C., MD, Ahmed, Catherine D., MBA, Kullo, Iftikhar J., MD, Gidding, Samuel S., MD, Duffy, Danielle, MD, Neal, William, MD, Wilemon, Katherine, BS, Roe, Matthew T., MD, MHS, Rader, Daniel J., MD, Ballantyne, Christie M., MD, Linton, MacRae F., MD, Duell, P. Barton, MD, Shapiro, Michael D., MD, Moriarty, Patrick M., MD, Knowles, Joshua W., MD, PhD

“…Abstract Background In the US familial hypercholesterolemia (FH) patients are under-identified, despite an estimated prevalence of 1:200 to 1:500. Criteria to…”
Get full text

Familial hypercholesterolemia and estimation of US patients eligible for low-density lipoprotein apheresis after maximally tolerated lipid-lowering therapy by Vishwanath, Raghu, MSc, MS, MBA, Hemphill, Linda C., MD

“…Abstract Familial hypercholesterolemia (FH), an autosomal-dominant inherited disorder, can occur in either the heterozygous (HeFH) or homozygous (HoFH) state,…”
Get full text

The Cholesterol Lowering Atherosclerosis Study (CLAS): What it tells us about niacin/colestipol therapy by Hemphill, Linda C., MD

“…Highlights • Angiographic trials from the 1990s provide valuable information on the impact of LDL cholesterol reduction on atherosclerosis progression. • The…”
Get full text

Effects of Obesity, Body Composition, and Adiponectin on Carotid Intima-Media Thickness in Healthy Women by Lo, Janet, Dolan, Sara E., Kanter, Jenna R., Hemphill, Linda C., Connelly, Jean M., Lees, Robert S., Grinspoon, Steven K.

“…Context: Increased common carotid intima-media thickness (IMT) is predictive of coronary artery disease and stroke. Objective: In this study, we investigated…”
Get full text

Carotid Intimal Medial Thickness in Human Immunodeficiency Virus-Infected Women: Effects of Protease Inhibitor Use, Cardiac Risk Factors, and the Metabolic Syndrome by Johnsen, Stine, Dolan, Sara E., Fitch, Kathleen V., Kanter, Jenna R., Hemphill, Linda C., Connelly, Jean M., Lees, Robert S., Lee, Hang, Grinspoon, Steve

“…Context: Little is known regarding carotid intimal medial thickness (IMT) in HIV-infected women and the risk factors for subclinical atherosclerosis in this…”
Get full text

Familial hypercholesterolemia: Current treatment options and patient selection for low-density lipoprotein apheresis by Hemphill, Linda C., MD

“…Abstract Options for treatment of severe heterozygous and homozygous familial hypercholesterolemia prior to the statin era were limited by significant side…”
Get full text

Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States by deGoma, Emil M, Ahmad, Zahid S, O'Brien, Emily C, Kindt, Iris, Shrader, Peter, Newman, Connie B, Pokharel, Yashashwi, Baum, Seth J, Hemphill, Linda C, Hudgins, Lisa C, Ahmed, Catherine D, Gidding, Samuel S, Duffy, Danielle, Neal, William, Wilemon, Katherine, Roe, Matthew T, Rader, Daniel J, Ballantyne, Christie M, Linton, MacRae F, Duell, PBarton, Shapiro, Michael D, Moriarty, Patrick M, Knowles, Joshua W

“…Background-Cardiovascular disease burden and treatment patterns among patients with familial hypercholesterolemia (FH) in the United States remain poorly…”
Get full text

Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry by Duell, P. Barton, Gidding, Samuel S., Andersen, Rolf L., Knickelbine, Thomas, Anderson, Lars, Gianos, Eugenia, Shrader, Peter, Kindt, Iris, O'Brien, Emily C., McCann, Dervilla, Hemphill, Linda C., Ahmed, Catherine D., Martin, Seth S., Larry, John A., Ahmad, Zahid S., Kullo, Iftikhar J., Underberg, James A., Guyton, John, Thompson, Paul, Wilemon, Katherine, Roe, Matthew T., Rader, Daniel J., Cuchel, Marina, Linton, MacRae F., Shapiro, Michael D., Moriarty, Patrick M., Knowles, Joshua W.

“…There are limited data from the US on outcomes of patients in specialty care for familial hypercholesterolemia (FH). CASCADE FH Registry data were analyzed to…”
Get full text

Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry by deGoma, Emil M, Ahmad, Zahid S, O’Brien, Emily C, Kindt, Iris, Shrader, Peter, Newman, Connie B, Pokharel, Yashashwi, Baum, Seth J, Hemphill, Linda C, Hudgins, Lisa C, Ahmed, Catherine D, Gidding, Samuel S, Duffy, Danielle, Neal, William, Wilemon, Katherine, Roe, Matthew T, Rader, Daniel J, Ballantyne, Christie M, Linton, MacRae F, Duell, P Barton, Shapiro, Michael D, Moriarty, Patrick M, Knowles, Joshua W

“…BACKGROUND—Cardiovascular disease burden and treatment patterns among patients with familial hypercholesterolemia (FH) in the United States remain poorly…”
Get full text

Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry by Amrock, Stephen M., Duell, P. Barton, Knickelbine, Thomas, Martin, Seth S., O'Brien, Emily C., Watson, Karol E., Mitri, Joanna, Kindt, Iris, Shrader, Peter, Baum, Seth J., Hemphill, Linda C., Ahmed, Catherine D., Andersen, Rolf L., Kullo, Iftikhar J., McCann, Dervilla, Larry, John A., Murray, Michael F., Fishberg, Robert, Guyton, John R., Wilemon, Katherine, Roe, Matthew T., Rader, Daniel J., Ballantyne, Christie M., Underberg, James A., Thompson, Paul, Duffy, Dannielle, Linton, MacRae F., Shapiro, Michael D., Moriarty, Patrick M., Knowles, Joshua W., Ahmad, Zahid S.

“…Most familial hypercholesterolemia (FH) patients remain undertreated, and it is unclear what role health disparities may play for FH patients in the US. We…”
Get full text