Search Results - "Hemmings, B."

Physiological roles of PKB/Akt isoforms in development and disease by Dummler, B, Hemmings, B A

“…PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal…”
Get more information

PKB AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage by Vichalkovski, A, Gresko, E, Hess, D, Restuccia, D F, Hemmings, B A

“…Protein kinase B (PKB/Akt) is ubiquitously expressed in cells. Phosphorylation of its multiple targets in response to various stimuli, including growth factors…”
Get full text

The influence of long- and short-term volcanic strain on aquifer pressure: a case study from Soufrière Hills Volcano, Montserrat (W.I.) by Strehlow, K, Gottsmann, J, Rust, A, Hautmann, S, Hemmings, B

“…Summary Aquifers are poroelastic bodies that respond to strain by changes in pore pressure. Crustal deformation due to volcanic processes induces pore pressure…”
Get full text

Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme by Wang, Y, Moncayo, G, Morin, P, Xue, G, Grzmil, M, Lino, M M, Clément-Schatlo, V, Frank, S, Merlo, A, Hemmings, B A

“…The infiltration of glioma cells into adjacent tissue is one of the major obstacles in the therapeutic management of malignant brain tumours, in most cases…”
Get full text

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a) by Brunet, Anne, Park, Jongsun, Tran, Hien, Hu, Linda S., Hemmings, Brian A., Greenberg, Michael E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Akt Signaling: Linking Membrane Events to Life and Death Decisions by Hemmings, Brian A.

“…Many growth factors exert their effects on cells by simulating intracellular kinases, which add phosphate groups to proteins. Two reports on p. 661 and p. 665…”
Get full text

Serine/threonine protein phosphatases by Wera, S, Hemmings, B A

Get full text

Mechanism of activation of protein kinase B by insulin and IGF‐1 by Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., Hemmings, B. A.

“…Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12‐fold in L6 myotubes, while after transfection into 293 cells…”
Get full text

Physiological functions of protein kinase B/Akt by Yang, Z-Z, Tschopp, O, Baudry, A, Dümmler, B, Hynx, D, Hemmings, B A

“…The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity…”
Get more information

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations by Green, B D, Jabbour, A M, Sandow, J J, Riffkin, C D, Masouras, D, Daunt, C P, Salmanidis, M, Brumatti, G, Hemmings, B A, Guthridge, M A, Pearson, R B, Ekert, P G

“…The activation of the Akt signalling in response to cytokine receptor signalling promotes protein synthesis, cellular growth and proliferation. To determine…”
Get full text

Stress appraisals, emotions, and coping among international adolescent golfers by Nicholls, A. R., Hemmings, B., Clough, P. J.

“…The aims of this study were to (a) explore the emotions generated during or as a consequence of stress appraisals, after coping, and after the event outcome,…”
Get full text

Ten years of protein kinase B signalling: a hard Akt to follow by Brazil, Derek P., Hemmings, Brian A.

“…It is ten years since the publication of three papers describing the cloning of a new proto-oncogene serine/threonine kinase termed protein kinase B (PKB)/Akt…”
Get full text

PKB/Akt-Dependent Regulation of Cell Motility by Xue, G., Hemmings, B. A.

Get full text

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B by Cross, Darren A. E, Alessi, Dario R, Cohen, Philip, Andjelkovich, Mirjana, Hemmings, Brian A

“…Glycogen synthase kinase-3 (GSK3) is implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis…”
Get full text

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells by HAJDUCH, E, ALESSI, D. R, HEMMINGS, B. A, HUNDAL, H. S

“…Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation…”
Get full text

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage by Gresko, E, Ritterhoff, S, Sevilla-Perez, J, Roscic, A, Fröbius, K, Kotevic, I, Vichalkovski, A, Hess, D, Hemmings, B A, Schmitz, M L

“…The promyelocytic leukemia (PML) tumor suppressor protein, a central regulator of cell proliferation and apoptosis, is frequently fused to the retinoic acid…”
Get full text

Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane by Maira, Sauveur-Michel, Galetic, Ivana, Brazil, Derek P., Kaech, Stefanie, Ingley, Evan, Thelen, Marcus, Hemmings, Brian A.

“…The PKB (protein kinase B, also called Akt) family of protein kinases plays a key role in insulin signaling, cellular survival, and transformation. PKB is…”
Get full text

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry by Tchorz, J S, Tome, M, Cloëtta, D, Sivasankaran, B, Grzmil, M, Huber, R M, Rutz-Schatzmann, F, Kirchhoff, F, Schaeren-Wiemers, N, Gassmann, M, Hemmings, B A, Merlo, A, Bettler, B

“…Recent studies identified a highly tumorigenic subpopulation of glioma stem cells (GSCs) within malignant gliomas. GSCs are proposed to originate from…”
Get full text

Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes by Frederiksen, C. M, Højlund, K, Hansen, L, Oakeley, E. J, Hemmings, B, Abdallah, B. M, Brusgaard, K, Beck-Nielsen, H, Gaster, M

“…Aims/hypothesis Microarray-based studies of skeletal muscle from patients with type 2 diabetes and high-risk individuals have demonstrated that insulin…”
Get full text

PtdIns(3,4,5)P3 gets its message across by HEMMINGS, B. A

Get full text