Search Results - "Hemmer, Martina"

Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis by Devata, Sumana, Angelini, Dana E., Blackburn, Susan, Hawley, Angela, Myers, Daniel D., Schaefer, Jordan K., Hemmer, Martina, Magnani, John L., Thackray, Helen M., Wakefield, Thomas W., Sood, Suman L.

“…There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion…”
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First in Human Phase 1 Single Dose Escalation Studies of the E-Selectin Antagonist GMI-1271 Show a Favorable Safety, Pharmacokinetic, and Biomarker Profile by Devata, Sumana, Sood, Suman L., Hemmer, Martina V, Flanner, Henry, Kramer, William, Nietubicz, Christine, Hawley, Angela, Angelini, Dana E, Myers, Daniel Durant, Blackburn, Susan, Froehlich, James, Wakefield, Thomas W., Magnani, John L., Thackray, Helen M.

“…▪ Background: GMI-1271 is a potent, specific E-selectin antagonist which targets interactions between cancer cells and the bone marrow niche thereby increasing…”
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E-Selectin Antagonist GMI-1271 Shows a Favorable Safety, PK and Bleeding Profile in Phase I Studies of Healthy Volunteers by Angelini, Dana E., Devata, Sumana, Hawley, Angela E., Blackburn, Susan A., Grewal, Satwinder, Hemmer, Martina V, Flanner, Henry, Kramer, William, Parker, William E, Li, Yu-Ling, Myers, Daniel Durant, Froehlich, James B., Magnani, John L, Thackray, Helen M., Wakefield, Thomas W., Sood, Suman L.

“…Background: Selectins, among other adhesion-mediated functions, facilitate and augment thrombosis; standard anticoagulants address thrombosis but also increase…”
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