Search Results - "Hemenway, Jeffrey N."

Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy by Gesenberg, Christoph, Mathias, Neil R., Xu, Yan, Crison, John, Savant, Ishani, Saari, Amy, Good, David J., Hemenway, Jeffrey N., Narang, Ajit S., Schartman, Richard R., Zheng, Naiyu, Buzescu, Adela, Patel, Jatin

“…Purpose To describe a stepwise approach to evaluate the pH effect for a weakly basic drug by in vitro , in vivo and in silico techniques and identify a viable…”
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Formation of reactive impurities in aqueous and neat polyethylene glycol 400 and effects of antioxidants and oxidation inducers by Hemenway, Jeffrey N, Carvalho, Thiago C, Rao, Venkatramana M, Wu, Yongmei, Levons, Jaquan K, Narang, Ajit S, Paruchuri, Srinivasa R, Stamato, Howard J, Varia, Sailesh A

“…A 2,4-dinitrophenylhydrazine (DNPH) precolumn derivatization high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed to…”
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In vitro and in vivo evaluation of a novel water-soluble N-glycyl prodrug (N-GLY-CBZ) of carbamazepine by Hemenway, Jeffrey N, Stella, Valentino J

“…The synthesis and characterization of N-glycyl-carbamazepine (N-Gly-CBZ), an N-acyl urea derivative of carbamazepine (CBZ) designed to act as a prodrug and…”
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Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine by Hemenway, Jeffrey N, Jarho, Pekka, Henri, John T, Nair, Sajiv K, VanderVelde, David, Georg, Gunda I, Stella, Valentino J

“…N-acyl-urea derivatives of carbamazepine (CBZ) were synthesized through the reactions of iminostilbene with acyl-isocyanates to form N-glycyl-carbamazepine…”
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Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine by Hemenway, Jeffrey N., Nti-Addae, Kwame, Guarino, Victor R., Stella, Valentino J.

“…The objective of this report is to introduce the novel application of sulfenamides as water-soluble prodrugs of the urea compound, carbamazaepine. Improved…”
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Preparation, physicochemical properties and animal studies of new water -soluble prodrugs of carbamazepine and oxcarbazepine by Hemenway, Jeffrey N

“…The objective of this research was to develop new water-soluble prodrugs of carbamazepine (CBZ) and oxcarbazepine (OXC) that are suitable for parenteral and…”
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Preparation, physicochemical properties and animal studies of new water-soluble prodrugs of carbamazepine and oxcarbazepine by Hemenway, Jeffrey N

“…The objective of this research was to develop new water-soluble prodrugs of carbamazepine (CBZ) and oxcarbazepine (OXC) that are suitable for parenteral and…”
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Evaluation of quantitative structure property relationships necessary for enantioresolution with lambda- and sulfobutylether lambda-carrageenan in capillary electrophoresis by Beck, Gregory M., Neau, Steven H., Holder, Andrew J., Hemenway, Jeffrey N.

“…Lambda‐carrageenan, a linear, high molecular weight sulfated polysaccharide, was successfully employed in both its native and sulfobutyl derivatized form as a…”
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