Search Results - "Hemenway, David R."

Interleukin-12 is not essential for silicosis in mice by Davis, Gerald S, Pfeiffer, Linda M, Hemenway, David R, Rincon, Mercedes

“…Silicosis features foci of inflammation where macrophages and lymphocytes precede and accompany fibroblast proliferation, alveolar epithelial hyperplasia, and…”
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INHALED PARTICLE-BOUND SULFATE: Effects on Pulmonary Inflammatory Responses and Alveolar Macrophage Function by Clarke, R W, Antonini, J M, Hemenway, D R, Frank, R, Kleeberger, S R, Jakab, G J

“…Acid sulfate-coated solid particles are a significant environmental hazard produced primarily by the combustion of fossil fuels. We have previously described a…”
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Asbestos Inhalation Induces Tyrosine Nitration Associated with Extracellular Signal-Regulated Kinase 1/2 Activation in the Rat Lung by Iwagaki, Akitaka, Choe, Nonghoon, Li, Yingyue, Hemenway, David R, Kagan, Elliott

“…Nitration of proteins by peroxynitrite (ONOO-) has been shown to critically alter protein function in vitro. We have shown previously that asbestos inhalation…”
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Interferon-gamma Production by Specific Lung Lymphocyte Phenotypes in Silicosis in Mice by Davis, Gerald S, Pfeiffer, Linda M, Hemenway, David R

“…We recently described overproduction of interferon (IFN)-gamma by lung lymphocytes in mice with silicosis (11% of cells in air-control versus 19% of cells from…”
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Nitrogen Dioxide Induces Death in Lung Epithelial Cells in a Density-Dependent Manner by Persinger, Rebecca L, Blay, Wendy M, Heintz, Nicholas H, Hemenway, David R, Janssen-Heininger, Yvonne M. W

“…Nitrogen dioxide (*NO2) is commonly known as an indoor and outdoor air pollutant. Inhalation of *NO2 is associated with epithelial cell injury, inflammation,…”
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Lymphocytes, lymphokines, and silicosis by Davis, G S, Holmes, C E, Pfeiffer, L M, Hemenway, D R

“…Silicosis is characterized by mononuclear cell aggregation with mineral particles and fibrosis. Lymphocytes are abundant in these lesions. We exposed inbred…”
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Expansion of Interferon-gamma -Producing Lung Lymphocytes in Mouse Silicosis by Davis, Gerald S, Pfeiffer, Linda M, Hemenway, David R

“…Silicosis is characterized by mononuclear cell inflammation with macrophage activation, accumulation of lymphocytes, and fibrosis. Interferon-gamma (IFN-gamma)…”
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T-lymphocyte activation in the enlarged thoracic lymph nodes of rats with silicosis by Garn, H, Friedetzky, A, Davis, G S, Hemenway, D R, Gemsa, D

“…Silicosis is primarily a mononuclear cell inflammatory and fibrotic disease of the pulmonary parenchyma. It is known that lung-associated lymph nodes are also…”
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Asbestos exposure upregulates the adhesion of pleural leukocytes to pleural mesothelial cells via VCAM-1 by Choe, N, Zhang, J, Iwagaki, A, Tanaka, S, Hemenway, D R, Kagan, E

“…This study was designed to assess the effects of in vitro and in vivo asbestos exposure on the adhesion of rat pleural leukocytes (RPLs) labeled with the…”
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ASBESTOS EXPOSURE INDUCES MCP-1 SECRETION BY PLEURAL MESOTHELIAL CELLS by Shogo Tanaka, Nonghoon Choe, Akigawa Iwagaki, David R. Hemenway, Elliott Kagan

“…We showed previously that both crocidolite and chrysotile asbestos inhalation induced a persistent macrophage in ammatory response within the pleural space of…”
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QUANTITATIVE IMAGE ANALYSIS OF LUNG CONNECTIVE TISSUE IN MURINE SILICOSIS by Antonini, James M., Hemenway, David R., Davis, Gerald S.

“…Pulmonary brosis is a disabling consequence of many lung diseases but is difficult to quantify. Lucifer yellow CH uorescent dye (LY) appears to stain…”
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CHARACTERISTICS OF AN AEROSOL PHOTOMETER WHILE AUTOMATICALLY CONTROLLING CHAMBER DILUTION-AIR FLOW RATE by Patrick T. O'Shaughnessy, David R. Hemenway

“…Trials were conducted to determine those factors that affect the accuracy of a directreading aerosol photometer when automatically controlling airflow rate…”
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Pleural Macrophage Recruitment and Activation in Asbestos-Induced Pleural Injury by Choe, Nonghoon, Tanaka, Shogo, Xia, Weijia, Hemenway, David R., Roggli, Victor L., Kagan, Elliott

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Intrathoracic distribution and transport of aerosolized silica in the rat by Absher, M P, Hemenway, D R, Leslie, K O, Trombley, L, Vacek, P

“…Short-term exposure of rats to aerosols of the silicon dioxide, cristobalite, leads to pulmonary inflammation persisting several months. Clearance of particles…”
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Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat by Tanaka, S, Choe, N, Hemenway, D R, Zhu, S, Matalon, S, Kagan, E

“…To determine whether asbestos inhalation induces the formation of reactive nitrogen species, three groups of rats were exposed intermittently over 2 wk to…”
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Pleural Macrophage Recruitment and Activation in Asbestos-Induced Pleural Injury by Choe, Nonghoon, Tanaka, Shogo, Xia, Weijia, Hemenway, David R., Roggli, Victor L., Kagan, Elliott

“…The pathogenesis of asbestos-induced pleural fibrosis is poorly understood. Moreover, there has been a long-standing controversy regarding the relative…”
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Interferon-(gamma) production by specific lung lymphocyte phenotypes in silicosis in mice by Davis, Gerald S, Pfeiffer, Linda M, Hemenway, David R

“…We recently described overproduction of interferon (IFN)-gamma by lung lymphocytes in mice with silicosis (11% of cells in air-control versus 19% of cells from…”
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Nonuniform air flow in inlets: the effect on filter deposits in the fiber sampling cassette by Baron, P A, Chen, C C, Hemenway, D R, O'Shaughnessy, P

“…Smoke stream studies were combined with a new technique for visualizing a filter deposit from samples used to monitor asbestos or other fibers. Results clearly…”
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What is the relationship between hemolytic potential and fibrogenicity of mineral dusts? by Hemenway, D R, Absher, M P, Fubini, B, Bolis, V

“…The hemolytic reaction to a dust is often used as a potential indicator of fibrogenicity of silicon dioxide polymorphs. However, occasionally the hemolytic…”
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Silicosis in mice: effects of dose, time, and genetic strain by Davis, G S, Leslie, K O, Hemenway, D R

“…Experimental silicosis allows study of the mechanisms of lung injury, inflammation, and fibrosis. Inbred mice are an attractive species in which to study these…”
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