Search Results - "Hembry, Rosalind M"

Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development by Little, Christopher B., Meeker, Clare T., Hembry, Rosalind M., Sims, Natalie A., Lawlor, Kate E., Golub, Sue B., Last, Karena, Fosang, Amanda J.

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Stromelysin-2 is Upregulated During Normal Wound Repair and is Induced by Cytokines by Rechardt, Oona, Vaalamo, Maarit, Höök-Nikanne, Johanna, Saarialho-Kere, Ulpu, Elomaa, Outi, Pääkkönen, Kati, Jahkola, Tiina, Hembry, Rosalind M., Häkkinen, Lari, Kere, Juha

“…Stromelysin-2 is a matrix metalloproteinase that degrades in vitro several protein components relevant to wound repair such as collagens III and IV, gelatin,…”
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MT1-MMP on the cell surface causes focal degradation of gelatin films by d'Ortho, Marie-Pia, Stanton, Heather, Butler, Michael, Atkinson, Susan J, Murphy, Gillian, Hembry, Rosalind M

“…The membrane-type matrix metalloproteinases (MT-MMPs) are a subclass of the matrix metalloproteinase (MMP) family which uniquely possess a C-terminal…”
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Matrix metalloproteinase‐2 activation in human hepatic fibrosis regulation by cell‐matrix interactions by Préaux, Anne‐Marie, Mallat, Ariane, Van Nhieu, Jeanne Tran, d'Ortho, Marie‐Pia, Hembry, Rosalind M., Mavier, Philippe

“…Matrix metalloproteinase‐2 (MMP‐2) is involved in extracellular matrix remodeling. It is secreted as a proenzyme and activated by membrane type‐MMPs (MT‐MMP),…”
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Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3 by Cowell, S, Knäuper, V, Stewart, M L, D'Ortho, M P, Stanton, H, Hembry, R M, López-Otín, C, Reynolds, J J, Murphy, G

“…SW1353 chondrosarcoma cells cultured in the presence of interleukin-1, concanavalin A or PMA secreted procollagenase 3 (matrix metalloproteinase-13). The…”
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Immunolocalization of Matrix Metalloproteinases in Partial-Thickness Defects in Pig Articular Cartilage : A Preliminary Report by Hembry, Rosalind M, Dyce, Jonathan, Driesang, Iris, Hunziker, Ernst B, Fosang, Amanda J, Tyler, Jenny A, Murphy, Gillian

“…BackgroundPartial-thickness defects in mature articular cartilage do not heal spontaneously. Attempts at repair often result in limited integration between the…”
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Assessment of gelatinase expression and activity in articular cartilage by Hembry, Rosalind M, Atkinson, Susan J, Murphy, Gillian

“…Two methods for the assessment of the expression of gelatinases A and B, MMP-2 and MMP-9, in articular cartilage are described. Immunohistochemical analysis of…”
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Generation and Novel Distribution of Matrix Metalloproteinase-derived Aggrecan Fragments in Porcine Cartilage Explants by Fosang, Amanda J., Last, Karena, Stanton, Heather, Weeks, David B., Campbell, Ian K., Hardingham, Timothy E., Hembry, Rosalind M.

“…We have studied aggrecan catabolism mediated by matrix metalloproteinases (MMPs) in a porcine cartilage culture system. Using antibodies specific for DIPEN341…”
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The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts by Hill, P A, Murphy, G, Docherty, A J, Hembry, R M, Millican, T A, Reynolds, J J, Meikle, M C

“…We have compared the effects of a general matrix metalloproteinase (MMP) inhibitor (CT435) with those of a concentration-dependent specific gelatinase…”
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Regulation of matrix metalloproteinases in a model of colonic wound healing in a rabbit by Shaper, K R, Savage, F J, Hembry, R M, Boulos, P B

“…Matrix metalloproteinases occur in the colon at an anastomosis but not in the normal colon. Matrix metalloproteinase synthesis can be regulated by cytokines,…”
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Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines by MEIKLE, M. C, BORD, S, HEMBRY, R. M, COMPSTON, J, CROUCHER, P. I, REYNOLDS, J. J

“…Collagenase production by rodent osteoblasts in response to calciotropic hormones has led to the hypothesis that bone cells play a major role in bone…”
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Comparison of the effects of vitamin A and its analogs upon rabbit ear cartilage in organ culture and upon growth of the vitamin A-deficient rat by Goodman, D S, Smith, J E, Hembry, R M, Dingle, J T

“…A study was conducted to explore the relationship between the effects of vitamin A upon cartilage and the biological role of vitamin A in maintaining growth…”
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Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation by Knäuper, Vera, Will, Horst, López-Otin, Carlos, Smith, Bryan, Atkinson, Susan J., Stanton, Heather, Hembry, Rosalind M., Murphy, Gillian

“…Gelatinase A and membrane-type metalloproteinase (MT1-MMP) were able to process human procollagenase-3 (Mr 60,000) to the fully active enzyme (Tyr85 N…”
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Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme by Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, S J, Stanton, H, Hembry, R M, Murphy, G

“…Gelatinase A and membrane-type metalloproteinase (MT1-MMP) were able to process human procollagenase-3 (Mr 60,000) to the fully active enzyme (Tyr85 N…”
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Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone by Dew, G, Murphy, G, Stanton, H, Vallon, R, Angel, P, Reynolds, J J, Hembry, R M

“…There is strong evidence that matrix metalloproteinases (MMPs) play a crucial role during osteogenesis and bone remodelling. Their synthesis by osteoblasts has…”
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Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1 : implications for regulation of matrix degradation in liver by IREDALE, J. P, MURPHY, G, HEMBRY, R. M, FRIEDMAN, S L, ARTHUR, M. J. P

“…Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of…”
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Characterization of a specific antiserum to rabbit stromelysin and demonstration of the synthesis of collagenase and stromelysin by stimulated rabbit articular chondrocytes by Murphy, G, Hembry, R M, Reynolds, J J

“…An antiserum to rabbit bone stromelysin (proteoglycanase) was raised in sheep and characterized as specific, recognizing the enzyme from both different tissue…”
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Stromelysin (MMP‐3) Synthesis Is Up‐Regulated in Estrogen‐Deficient Mouse Osteoblasts In Vivo and In Vitro by Breckon, Jeremy J. W., Papaioannou, Stelios, Kon, Luke W. M., Tumber, Anthony, Hembry, Rosalind M., Murphy, Gillian, Reynolds, John J., Meikle, Murray C.

“…Sex steroids are important regulators of bone cell function and osteoblast‐derived matrix metalloproteinases (MMPs) are key mediators of bone resorption during…”
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Distribution of matrix metalloproteinases and their inhibitor, TIMP‐1, in developing human osteophytic bone by BORD, SHARYN, HORNER, ALAN, HEMBRY, ROSALIND M., REYNOLDS, JOHN J., COMPSTON, JULIET E.

“…Connective tissues synthesise and secrete a family of matrix metalloproteinases (MMPs) which are capable of degrading most components of the extracellular…”
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Role of matrix metalloproteinases in healing of colonic anastomosis by Savage, F J, Lacombe, D L, Boulos, P B, Hembry, R M

“…The aim of this study was to compare the distribution of the matrix metalloproteinases (MMPs) during anastomotic healing in a normal colon with that in an…”
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