Search Results - "Hembry, R M"

Stromelysin-1 (MMP-3) and Stromelysin-2 (MMP-10) Expression in Developing Human Bone: Potential Roles in Skeletal Development by Bord, S, Horner, A, Hembry, R.M, Compston, J.E

“…Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin,…”
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Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis by Hembry, R M, Bagga, M R, Reynolds, J J, Hamblen, D L

“…OBJECTIVE--To assess the likely importance of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the arthritic process. METHODS--Synovial samples…”
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Matrix metalloproteinase‐2 activation in human hepatic fibrosis regulation by cell‐matrix interactions by Préaux, Anne‐Marie, Mallat, Ariane, Van Nhieu, Jeanne Tran, d'Ortho, Marie‐Pia, Hembry, Rosalind M., Mavier, Philippe

“…Matrix metalloproteinase‐2 (MMP‐2) is involved in extracellular matrix remodeling. It is secreted as a proenzyme and activated by membrane type‐MMPs (MT‐MMP),…”
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Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1 : implications for regulation of matrix degradation in liver by IREDALE, J. P, MURPHY, G, HEMBRY, R. M, FRIEDMAN, S L, ARTHUR, M. J. P

“…Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of…”
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Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis by Flannelly, J., Chambers, M.G., Dudhia, J., Hembry, R.M., Murphy, G., Mason, R.M., Bayliss, M.T.

“…Objective To study the temporal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the STR/ort mouse model of…”
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Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone by Bord, S, Horner, A, Beeton, C.A, Hembry, R.M, Compston, J.E

“…Degradation of skeletal connective tissue is regulated, at least in part, by the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of…”
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The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 by WARD, R. V, HEMBRY, R. M, REYNOLDS, J. J, MURPHY, G

“…Human gingival fibroblasts in culture were shown to secrete a 72 kDa progelatinase, of which a proportion in the medium was found to be complexed with tissue…”
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Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine by Bailey, C J, Hembry, R M, Alexander, A, Irving, M H, Grant, M E, Shuttleworth, C A

“…AIMS--To investigate the role of the matrix metalloproteinases (MMPs) in the connective tissue changes seen in the intestine in Crohn's disease…”
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Generation and Novel Distribution of Matrix Metalloproteinase-derived Aggrecan Fragments in Porcine Cartilage Explants by Fosang, Amanda J., Last, Karena, Stanton, Heather, Weeks, David B., Campbell, Ian K., Hardingham, Timothy E., Hembry, Rosalind M.

“…We have studied aggrecan catabolism mediated by matrix metalloproteinases (MMPs) in a porcine cartilage culture system. Using antibodies specific for DIPEN341…”
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Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes : analysis of gene expression, protein synthesis and proteinase activity by ARTHUR, M. J. P, STANLEY, A, IREDALE, J. P, RAFFERTY, J. A, HEMBRY, R. M, FRIEDMAN, S. L

“…The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or…”
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Production of collagenase by human osteoblasts and osteoclasts in vivo by Bord, S., Horner, A., Hembry, R.M., Reynolds, J.J., Compston, J.E.

“…Studies in some animal species have demonstrated the production of metalloproteinases by bone cells, suggesting that they may play a role in bone modeling and…”
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Proteinases in rheumatoid arthritis by Murphy, G, Hembry, R M

“…The role of proteinases in the extracellular breakdown of the connective tissue matrix during disease processes is outlined. Focussing on the matrix…”
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Stromelysin (MMP‐3) Synthesis Is Up‐Regulated in Estrogen‐Deficient Mouse Osteoblasts In Vivo and In Vitro by Breckon, Jeremy J. W., Papaioannou, Stelios, Kon, Luke W. M., Tumber, Anthony, Hembry, Rosalind M., Murphy, Gillian, Reynolds, John J., Meikle, Murray C.

“…Sex steroids are important regulators of bone cell function and osteoblast‐derived matrix metalloproteinases (MMPs) are key mediators of bone resorption during…”
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Immunolocalization of metalloproteinases and their inhibitor in the rabbit growth plate by Brown, C C, Hembry, R M, Reynolds, J J

“…The synthesis and distribution of three metalloproteinases, collagenase, stromelysin, and gelatinase, and of the tissue inhibitor of metalloproteinase were…”
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Effect of colonic obstruction on the distribution of matrix metalloproteinases during anastomotic healing by Savage, F. J., Lacombe, D. L. P., Hembry, R. M., Boulos, P. B.

“…Background Anastomotic dehiscence is common after surgery for colonic obstruction. The strength of an anastomosis is dependent on collagen, which is degraded…”
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Binding of latent and high Mr active forms of stromelysin to collagen is mediated by the C-terminal domain by ALLAN, J. A, HEMBRY, R. M, ANGAL, S, REYNOLDS, J. J, MURPHY, G

“…A specific high-titre polyclonal antiserum to recombinant human prostromelysin was raised in a sheep and shown by immunoblotting to detect latent…”
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Commitment to Expression of the Metalloendopeptidases, Collagenase and Stromelysin: Relationship of Inducing Events to Changes in Cytoskeletal Architecture by Werb, Zena, Hembry, Rosalind M., Murphy, Gillian, Aggeler, Judith

“…Agents that alter the morphology of rabbit synovial fibroblasts induce synthesis of the metalloendopeptidases, collagenase and stromelysin. We studied the…”
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Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines by MEIKLE, M. C, BORD, S, HEMBRY, R. M, COMPSTON, J, CROUCHER, P. I, REYNOLDS, J. J

“…Collagenase production by rodent osteoblasts in response to calciotropic hormones has led to the hypothesis that bone cells play a major role in bone…”
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Immunolocalization of matrix metalloproteinases and TIMP-1 (tissue inhibitor of metalloproteinases) in human gingival tissues from periodontitis patients by Meikle, M C, Hembry, R M, Holley, J, Horton, C, McFarlane, C G, Reynolds, J J

“…The matrix metalloproteinases (MMPs) collagenase, gelatinase A (72 kDa gelatinase), stromelysin, and their specific inhibitor TIMP-1 (tissue inhibitor of…”
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Gelatinase (type IV collagenase) immunolocalization in cells and tissues: use of an antiserum to rabbit bone gelatinase that identifies high and low Mr forms by MURPHY, G, HEMBRY, R. M, MCGARRITY, A. M, REYNOLDS, J. J, HENDERSON, B

“…An antiserum was raised to rabbit bone gelatinase (type IV collagenase). It was shown by immunoblotting to detect both the low Mr (72,000) enzyme produced by…”
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