Search Results - "Hembre, Erik"

State income taxes and team performance by Hembre, Erik

“…Professional athletes are both highly paid and highly mobile workers. Previous research has shown that athletes respond to state income taxes differentials…”
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Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor by Wang, Xushan, Hembre, Erik J, Goldsmith, Paul J, Beck, James P, Svensson, Kjell A, Willard, Francis S, Bruns, Robert F

“…An amine-containing molecule called Compound A has been reported by a group from Bristol-Myers Squibb to act as a positive allosteric modulator (PAM) at the…”
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Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk by Chen, Qi, Zhou, Xin, Rehmel, Jessica, Steele, James P., Svensson, Kjell A., Beck, James P., Hembre, Erik J., Hao, Junliang

“…Three structurally closely related dopamine D1 receptor positive allosteric modulators (D1 PAMs) based on a tetrahydroisoquinoline (THIQ) scaffold were…”
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The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents by Zuniga, Edison S., Korkegian, Aaron, Mullen, Steven, Hembre, Erik J., Ornstein, Paul L., Cortez, Guillermo, Biswas, Kallolmay, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya

“…[Display omitted] We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the…”
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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor by McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J

“…The beta-site APP cleaving enzyme 1, known as BACE1, has been a widely pursued Alzheimer’s disease drug target owing to its critical role in the production of…”
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3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism by Gehlert, Donald R, Cippitelli, Andrea, Thorsell, Annika, Le, Anh Dzung, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus

“…We describe a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with advantageous properties for clinical development, and its in vivo activity…”
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In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs by Zhou, Xin, Hui, Yu-Hua, Hudson, Loyd, Katyayan, Kishore K, Mohutsky, Michael A, Hao, Junliang, Schober, Douglas A, Hembre, Erik J

“…1-Aminobenzotriazole (ABT) has been widely used as a nonspecific mechanism-based inhibitor of cytochrome P450 (P450) enzymes. It is extensively used in…”
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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints by Winneroski, Leonard L., Erickson, Jon A., Green, Steven J., Lopez, Jose E., Stout, Stephanie L., Porter, Warren J., Timm, David E., Audia, James E., Barberis, Mario, Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hembre, Erik J., Hendle, Jörg, Garcia-Losada, Pablo, Minguez, Jose Miguel, Mathes, Brian M., May, Patrick C., Monk, Scott A., Rankovic, Zoran, Shi, Yuan, Watson, Brian M., Yang, Zhixiang, Mergott, Dustin J.

“…[Display omitted] Inhibition of BACE1 has become an important strategy in the quest for disease modifying agents to slow the progression of Alzheimer’s…”
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Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis by Hembre, Erik, Early, Julie V, Odingo, Joshua, Shelton, Catherine, Anoshchenko, Olena, Guzman, Junitta, Flint, Lindsay, Dennison, Devon, McNeil, Matthew B, Korkegian, Aaron, Ovechkina, Yulia, Ornstein, Paul, Masquelin, Thierry, Hipskind, Philip A, Parish, Tanya

“…The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of…”
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Examining SNAP and TANF caseload trends, responsiveness, and policies during the COVID‐19 pandemic by Hembre, Erik

“…Temporary Assistance for Needy Families (TANF) and Supplemental Nutrition Assistance Program (SNAP) cases increased by 3.3 million between March and June 2020,…”
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An examination of the first-time homebuyer tax credit by Hembre, Erik

“…A major policy response to the 2008 housing crisis was the First-time Homebuyer Tax Credit, worth up to $8,000. To estimate the tax credit effects on…”
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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond by Ciccocioppo, Roberto, Gehlert, Donald R, Ryabinin, Andrey, Kaur, Simranjit, Cippitelli, Andrea, Thorsell, Annika, Lê, Anh D, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Economidou, Daina, Stopponi, Serena, Cannella, Nazzareno, Braconi, Simone, Kallupi, Marsida, de Guglielmo, Giordano, Massi, Maurizio, George, David T, Gilman, Jody, Hersh, Jacqueline, Tauscher, Johannes T, Hunt, Stephen P, Hommer, Daniel, Heilig, Markus

“…Abstract This article summarizes the proceedings of a symposium held at the conference on “Alcoholism and Stress: A Framework for Future Treatment Strategies”…”
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Tax incentives and housing decisions: Effects of the Tax Cut and Jobs Act by Hembre, Erik, Dantas, Raissa

“…We investigate the 2017 Tax Cut and Jobs Act (TCJA) that altered the US tax code, greatly reducing itemization rates and effective homeownership subsidies…”
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Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine by Pearson, William H, Hembre, Erik J

“…Swainsonine ( 1 ), an inhibitor of the important glycoprotein-processing enzyme Golgi α-mannosidase II, is a clinical candidate for cancer treatment. Analogs…”
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Synthesis of Novel Glycosidase-Inhibitory Hydroxymethyl-Substituted Polyhydroxylated Indolizidines:  Ring-Expanded Analogs of the Pyrrolizidine Alkaloids Alexine and Australine by Pearson, William H, Hembre, Erik J

“…The pyrrolizidine azasugars alexine (3) and australine (4) and their stereoisomers are glycosidase inhibitors of potential therapeutic use. Since the…”
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A study of the synthesis of triazoles using microwave irradiation by Savin, Kenneth A, Robertson, Michael, Gernert, Doug, Green, Steven, Hembre, Erik J, Bishop, Jessie

“…Herein we describe the conversion of a known [3+2] cycloaddition reaction between an azide and an acetylene from a thermally promoted reaction to a microwave…”
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Supplemental Nutrition Assistance Program and food expenditures: Evaluating California's cash‐out policy by Hembre, Erik, McElroy, Katherine, Ohannessian, Shogher

“…This paper investigates how Supplemental Nutrition Assistance Program (SNAP) eligibility affects food expenditures. A 2019 policy change in California granted…”
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A Practical Synthesis of (−)-Swainsonine by Pearson, William H, Hembre, Erik J

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A rising tide lifts all homes? Housing consumption trends for low-income households since the 1980s by Hembre, Erik, Collins, J. Michael, Wylde, Samuel

“…This study analyzes patterns of housing consumption and expenditures among low-income households since 1985. For households in the bottom income quintile, real…”
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Low‐Income Homeownership and the Role of State Subsidies: A Comparative Analysis of Mortgage Outcomes by Hembre, Erik, Moulton, Stephanie, Record, Matthew

“…Between the late 1970s through 2013, state Housing Finance Agencies (HFAs) financed nearly $300 billion in mortgages to low‐ and moderate‐income first‐time…”
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