Search Results - "Hemani, Humza"

Heterogeneity and transcriptome changes of human CD8+ T cells across nine decades of life by Lu, Jian, Ahmad, Raheel, Nguyen, Thomas, Cifello, Jeffrey, Hemani, Humza, Li, Jiangyuan, Chen, Jinguo, Li, Siyi, Wang, Jing, Achour, Achouak, Chen, Joseph, Colie, Meagan, Lustig, Ana, Dunn, Christopher, Zukley, Linda, Chia, Chee W., Burd, Irina, Zhu, Jun, Ferrucci, Luigi, Weng, Nan-ping

“…The decline of CD8 + T cell functions contributes to deteriorating health with aging, but the mechanisms that underlie this phenomenon are not well understood…”
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Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8 + T cell expansion by Yang, Qian, Patrick, Michael, Lu, Jian, Chen, Joseph, Zhang, Yongqing, Hemani, Humza, Lehrmann, Elin, De, Supriyo, Weng, Nan-Ping

“…T cell activation is a tightly controlled process involving both positive and negative regulators. The precise mechanisms governing the negative regulators in…”
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SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors by Choy, Cecily, Chen, Joseph, Li, Jiangyuan, Gallagher, D. Travis, Lu, Jian, Wu, Daichao, Zou, Ainslee, Hemani, Humza, Baptiste, Beverly A., Wichmann, Emily, Yang, Qian, Ciffelo, Jeffrey, Yin, Rui, McKelvy, Julia, Melvin, Denise, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Chia, Chee W., Fan, Jinshui, Ruffolo, Jeannie, Zukley, Linda, Shi, Guixin, Amano, Tomokazu, An, Yang, Meirelles, Osorio, Wu, Wells W., Chou, Chao-Kai, Shen, Rong-Fong, Willis, Richard A., Ko, Minoru S. H., Liu, Yu-Tsueng, De, Supriyo, Pierce, Brian G., Ferrucci, Luigi, Egan, Josephine, Mariuzza, Roy, Weng, Nan-Ping

“…The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8 + T cells play a vital role. Nonetheless, the characterization of the…”
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Longitudinal somatic mutation analysis of individual human CD8 +T cells by a UMI-based single cell mutation detection (USCMD) method by Hemani, Humza, Ahmad, Raheel, Cifello, Jeffrey, Li, Siyi, Li, Jiangyuan, Lu, Jian, Ellabaan, Mostafa, Weng, Nanping

“…Abstract Somatic mutation is a contributing factor for cancer and aging. DNA-based single-cell mutation detection methods have been developed, but are hindered…”
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Longitudinal analysis of IAV-specific CD8+ T cell response to the high dose influenza vaccine (Fluzone) in healthy older adults by Elbahnasawy, Mostafa, Lu, Jain, Reed, Quinton, Hemani, Humza, Li, Jiangyuan, Cifallo, Jeffrey, Li, Huifen, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Ruffolo, Jeannie, Zukley, Linda, Shi, Guixin, Fan, Jinshui, Liu, Yu-Tsueng, De, Supriyo, Chia, Chee

“…Abstract Influenza infection remains a leading cause of death among older adults worldwide. While vaccines offer an effective means of reducing the severity of…”
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Characterization of CD8 +T cells recognizing a dominant epitope of SARS-CoV-2 spike protein in COVID-19 convalescent, vaccinated, and unexposed individuals by Zou, Ainslee J, Li, Jiangyuan, Choy, Cecily, Chen, Joseph, Hemani, Humza, Baptiste, Beverly, McKelvey, Julia, Melvin, Denise, Ruffolo, Jeannie, Zukley, Linda, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Fan, Jinshui, De, Supriyo, Chia, Chee, Ferrucci, Luigi, Egan, Josephine, Weng, Nan-ping

“…Abstract COVID-19, an infectious disease caused by SARS-CoV-2, has given rise to the current global pandemic. Despite the number of infections reaching over…”
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Characterization of SARS-CoV-2-specific CD8+ T cells in COVID-19 convalescent, vaccinated, and individuals with respect to age by Choy, Cecily, Lu, Jian, Li, Jiangyuan, Hemani, Humza, Chen, Joseph, Lustig, Ana, McKelvey, Julia, Melvin, Denise, Ruffolo, Jeannie, Zukley, Linda, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Fan, Jinshui, De, Supriyo, Chia, Chee, Ferrucci, Luigi, Egan, Josephine, Weng, Nan-ping

“…Abstract COVID-19, an infectious disease caused by SARS-CoV-2, has given rise to the current global pandemic. Despite the number of infections nearing 300…”
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