Search Results - "Helvacıoğlu, Sinem"
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Assessment of toxic element content of some grape molasses produced by conventional and industrial techniques: insights into human safety
Published in Toxin reviews (02-10-2021)“…The level of arsenic, lead, cadmium, and aluminum in molasses produced by traditional and industrial techniques were investigated. The metal-induced…”
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Comprehensive estrogenic/anti-estrogenic, anticancer, mutagenic/anti-mutagenic, and genotoxic/anti-genotoxic activity studies on chemically characterized black poplar and Eurasian aspen propolis types
Published in Journal of pharmaceutical and biomedical analysis (20-03-2023)“…Propolis is mainly composed of plant resins, and its type is named according to the primary plant origin in its composition. Identification of propolis…”
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Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine—(thio)urea hybrids as potential kinase inhibitors
Published in Computational biology and chemistry (01-02-2019)“…[Display omitted] •It was aimed to design new kinase inhibitors as drug candidates.•32 new compounds with anticancer potential were designed and…”
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Identification of some novel amide conjugates as potent and gastric sparing anti-inflammatory agents: In vitro, in vivo, in silico studies and drug safety evaluation
Published in Journal of molecular structure (05-08-2023)“…•NSAIDs inhibiting COX-1 mainly holds many gastric side-effects.•To minimize their side-effects, ten NSAIDs were converted to amide derivatives.•The new…”
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Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
Published in Chemistry & biodiversity (01-10-2021)“…The antioxidant and mutagenic/antimutagenic activities of the fixed oils from Nigella sativa (NSO) and Nigella damascena (NDO) seeds, obtained by cold…”
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Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity
Published in Molecular diversity (01-10-2023)“…Some novel triazole-bearing ketone and oxime derivatives were synthesized from Ibuprofen. In vitro cytotoxic activities of all synthesized molecules against…”
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The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity
Published in Drug and chemical toxicology (New York, N.Y. 1978) (01-11-2024)“…Doxorubicin (Dox), an effective anticancer agent, is known for its genotoxic effects on normal cells. Phenolic compounds, renowned for their antitumor,…”
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Lead Optimization and Structure–Activity Relationship Studies on Myeloid Ecotropic Viral Integration Site 1 Inhibitor
Published in Journal of medicinal chemistry (14-10-2021)“…The pivotal role of the myeloid ecotropic viral integration site 1 (MEIS1) transcriptional factor was reported in cardiac regeneration and hematopoietic…”
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Chemical analysis, mutagenic and antimutagenic effects of Cynara scolymus L. plant parts
Published in Toxicology letters (20-10-2017)Get full text
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Safety evaluation of styrax liquidus from the viewpoint of genotoxicity and mutagenicity
Published in Journal of ethnopharmacology (24-12-2016)“…Styrax liquidus is a resinous exudate (balsam) obtained from the wounded trunk of the Liquidambar orientalis Mill. (Hamamelidaceae). Styrax has been used for…”
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Genotoxicity study of high aspect ratio silver nanowires
Published in Toxicological and environmental chemistry (03-07-2017)“…The genotoxicity potential of silver nanowires synthesized via the solution-based polyol method has been investigated. They were found to be non-mutagenic in…”
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