Search Results - "Helton, M."

Continental-scale analysis of shallow and deep groundwater contributions to streams by Hare, Danielle K., Helton, Ashley M., Johnson, Zachary C., Lane, John W., Briggs, Martin A.

“…Groundwater discharge generates streamflow and influences stream thermal regimes. However, the water quality and thermal buffering capacity of groundwater…”
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Cumulative impacts of mountaintop mining on an Appalachian watershed by Lindberg, T. Ty, Bernhardt, Emily S, Bier, Raven, Helton, A. M, Merola, R. Brittany, Vengosh, Avner, Di Giulio, Richard T

“…Mountaintop mining is the dominant form of coal mining and the largest driver of land cover change in the central Appalachians. The waste rock from these…”
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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential by Wong, Terrence N., Miller, Christopher A., Jotte, Matthew R. M., Bagegni, Nusayba, Baty, Jack D., Schmidt, Amy P., Cashen, Amanda F., Duncavage, Eric J., Helton, Nichole M., Fiala, Mark, Fulton, Robert S., Heath, Sharon E., Janke, Megan, Luber, Kierstin, Westervelt, Peter, Vij, Ravi, DiPersio, John F., Welch, John S., Graubert, Timothy A., Walter, Matthew J., Ley, Timothy J., Link, Daniel C.

“…Hematopoietic clones harboring specific mutations may expand over time. However, it remains unclear how different cellular stressors influence this expansion…”
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Increasing stand structural heterogeneity reduces productivity in Brazilian Eucalyptus monoclonal stands by Soares, Alvaro A.V., Leite, Helio G., Souza, Agostinho L., Silva, Sérgio R., Lourenço, Helton M., Forrester, David I.

“…•Tree size inequality in monoclonal stands is associated with decreasing production.•Genotype and stand density affect stand structural uniformity and…”
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Immune Escape of Relapsed AML Cells after Allogeneic Transplantation by Christopher, Matthew J, Petti, Allegra A, Rettig, Michael P, Miller, Christopher A, Chendamarai, Ezhilarasi, Duncavage, Eric J, Klco, Jeffery M, Helton, Nicole M, O’Laughlin, Michelle, Fronick, Catrina C, Fulton, Robert S, Wilson, Richard K, Wartman, Lukas D, Welch, John S, Heath, Sharon E, Baty, Jack D, Payton, Jacqueline E, Graubert, Timothy A, Link, Daniel C, Walter, Matthew J, Westervelt, Peter, Ley, Timothy J, DiPersio, John F

“…In patients who had a relapse of acute myeloid leukemia after allogeneic hematopoietic stem-cell transplantation, no characteristic genetic lesions were…”
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CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression by Spencer, David H., Russler-Germain, David A., Ketkar, Shamika, Helton, Nichole M., Lamprecht, Tamara L., Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Heath, Sharon E., Shinawi, Marwan, Westervelt, Peter, Payton, Jacqueline E., Wartman, Lukas D., Welch, John S., Wilson, Richard K., Walter, Matthew J., Link, Daniel C., DiPersio, John F., Ley, Timothy J.

“…DNMT3A mutations occur in ∼25% of acute myeloid leukemia (AML) patients. The most common mutation, DNMT3AR882H, has dominant negative activity that reduces DNA…”
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Morpheus Reveals Distant Disk Galaxy Morphologies with JWST: The First AI/ML Analysis of JWST Images by Robertson, Brant E., Tacchella, Sandro, Johnson, Benjamin D., Hausen, Ryan, Alabi, Adebusola B., Boyett, Kristan, Bunker, Andrew J., Carniani, Stefano, Egami, Eiichi, Eisenstein, Daniel J., Hainline, Kevin N., Helton, Jakob M., Ji, Zhiyuan, Kumari, Nimisha, Lyu, Jianwei, Maiolino, Roberto, Nelson, Erica J., Rieke, Marcia J., Shivaei, Irene, Sun, Fengwu, Übler, Hannah, Williams, Christina C., Willmer, Christopher N. A., Witstok, Joris

“…Abstract The dramatic first images with JWST demonstrated its power to provide unprecedented spatial detail for galaxies in the high-redshift universe. Here,…”
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Superlinear scaling of riverine biogeochemical function with watershed size by Wollheim, Wilfred M., Harms, Tamara K., Robison, Andrew L., Koenig, Lauren E., Helton, Ashley M., Song, Chao, Bowden, William B., Finlay, Jacques C.

“…River networks regulate carbon and nutrient exchange between continents, atmosphere, and oceans. However, contributions of riverine processing are poorly…”
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Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies by Cole, Christopher B, Russler-Germain, David A, Ketkar, Shamika, Verdoni, Angela M, Smith, Amanda M, Bangert, Celia V, Helton, Nichole M, Guo, Mindy, Klco, Jeffery M, O'Laughlin, Shelly, Fronick, Catrina, Fulton, Robert, Chang, Gue Su, Petti, Allegra A, Miller, Christopher A, Ley, Timothy J

“…The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia genomes. Point mutations at position R882 have…”
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Brown Dwarf Candidates in the JADES and CEERS Extragalactic Surveys by Hainline, Kevin N., Helton, Jakob M., Johnson, Benjamin D., Sun, Fengwu, Topping, Michael W., Leisenring, Jarron M., Baker, William M., Eisenstein, Daniel J., Hausen, Ryan, Hviding, Raphael E., Lyu, Jianwei, Robertson, Brant, Tacchella, Sandro, Williams, Christina C., Willmer, Christopher N. A., Roellig, Thomas L.

“…Abstract By combining the James Webb Space Telescope (JWST)/NIRCam JADES and CEERS extragalactic data sets, we have uncovered a sample of 21 T and Y brown…”
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An ecohydrological typology for thermal refuges in streams and rivers by Sullivan, Christopher J., Vokoun, Jason C., Helton, Ashley M., Briggs, Martin A., Kurylyk, Barret L.

“…Thermal refuges are thermally distinct riverscape features used by aquatic organisms during unfavourable thermal events, facilitating resilience in marginal…”
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Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML by Wong, Terrence N., Miller, Christopher A., Klco, Jeffery M., Petti, Allegra, Demeter, Ryan, Helton, Nichole M., Li, Tiandao, Fulton, Robert S., Heath, Sharon E., Mardis, Elaine R., Westervelt, Peter, DiPersio, John F., Walter, Matthew J., Welch, John S., Graubert, Timothy A., Wilson, Richard K., Ley, Timothy J., Link, Daniel C.

“…There is interest in using leukemia-gene panels and next-generation sequencing to assess acute myelogenous leukemia (AML) response to induction chemotherapy…”
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Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome by Smith, Amanda M., LaValle, Taylor A., Shinawi, Marwan, Ramakrishnan, Sai M., Abel, Haley J., Hill, Cheryl A., Kirkland, Nicole M., Rettig, Michael P., Helton, Nichole M., Heath, Sharon E., Ferraro, Francesca, Chen, David Y., Adak, Sangeeta, Semenkovich, Clay F., Christian, Diana L., Martin, Jenna R., Gabel, Harrison W., Miller, Christopher A., Ley, Timothy J.

“…Germline pathogenic variants in DNMT3A were recently described in patients with overgrowth, obesity, behavioral, and learning difficulties ( D NMT3A O…”
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JADES: Spectroscopic Confirmation and Proper Motion for a T-Dwarf at 2 kpc by Hainline, Kevin N., D’Eugenio, Francesco, Sun, Fengwu, Helton, Jakob M., Miles, Brittany E., Marley, Mark S., Lew, Ben W. P., Leisenring, Jarron M., Bunker, Andrew J., Cargile, Phillip A., Carniani, Stefano, Eisenstein, Daniel J., Juodžbalis, Ignas, Johnson, Benjamin D., Robertson, Brant, Tacchella, Sandro, Williams, Christina C., Willmer, Christopher N. A.

“…Abstract Large area observations of extragalactic deep fields with the James Webb Space Telescope (JWST) have provided a wealth of candidate low-mass L- and…”
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Identification of High-redshift Galaxy Overdensities in GOODS-N and GOODS-S by Helton, Jakob M., Sun, Fengwu, Woodrum, Charity, Hainline, Kevin N., Willmer, Christopher N. A., Rieke, Marcia J., Rieke, George H., Alberts, Stacey, Eisenstein, Daniel J., Tacchella, Sandro, Robertson, Brant, Johnson, Benjamin D., Baker, William M., Bhatawdekar, Rachana, Bunker, Andrew J., Chen, Zuyi, Egami, Eiichi, Ji, Zhiyuan, Maiolino, Roberto, Willott, Chris, Witstok, Joris

“…Abstract We conduct a systematic search for high-redshift galaxy overdensities at 4.9 < z spec < 8.9 in both the Great Observatories Origins Deep Survey…”
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Where the past meets the present: connecting nitrogen from watersheds to streams through groundwater flowpaths by Moore, Eric M, Barclay, Janet R, Haynes, Adam B, Jackson, Kevin E, Bisson, Alaina M, Briggs, Martin A, Helton, Ashley M

“…Abstract Groundwater discharge to streams is a nonpoint source of nitrogen (N) that confounds N mitigation efforts and represents a significant portion of the…”
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Carbon Dynamics Vary Among Tidal Marsh Plant Species in a Sea-level Rise Experiment by Barry, Aidan, Ooi, Sean Khan, Helton, Ashley M., Steven, Blaire, Elphick, Chris S., Lawrence, Beth A.

“…Tidal wetlands are important blue carbon reservoirs, but it is unclear how sea-level rise (SLR) may affect carbon cycling and soil microbial communities either…”
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Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype by Tian, Ling, Chavez, Monique, Chang, Gue Su, Helton, Nichole M, Katerndahl, Casey D S, Miller, Christopher A, Wartman, Lukas D

“…Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome (Uty) (Zheng et al. 2018). We…”
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Modeling the Effect of Temperature on Membrane Response of Light Stimulation in Optogenetically-Targeted Neurons by Peixoto, Helton M, Cruz, Rossana M S, Moulin, Thiago C, Leão, Richardson N

“…Optogenetics is revolutionizing Neuroscience, but an often neglected effect of light stimulation of the brain is the generation of heat. In extreme cases,…”
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Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells by Spencer, D H, Young, M A, Lamprecht, T L, Helton, N M, Fulton, R, O'Laughlin, M, Fronick, C, Magrini, V, Demeter, R T, Miller, C A, Klco, J M, Wilson, R K, Ley, T J

“…HOX genes are highly expressed in many acute myeloid leukemia (AML) samples, but the patterns of expression and associated regulatory mechanisms are not…”
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